Relationship of recurrence rate with some characteristics in patients with thyroid carcinoma
Background: Determining the clinical and subclinical characteristics related to the recurrence status in patients with a thyroid carcinoma has great significance for prognosis, prediction of recurrence and monitoring of treatment outcomes. This study aimed to determine the association between recurr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=6;spage=544;epage=551;aulast=M. |
| _version_ | 1797300058632224768 |
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| author | Tri D M. Bui Chi D P. Bui Hiep T Bui Trung H Nguyen Minh D Tong Dung T N. Nguyen Thanh D Bui Viet Q Tran Hiep T Nguyen |
| author_facet | Tri D M. Bui Chi D P. Bui Hiep T Bui Trung H Nguyen Minh D Tong Dung T N. Nguyen Thanh D Bui Viet Q Tran Hiep T Nguyen |
| author_sort | Tri D M. Bui |
| collection | DOAJ |
| description | Background: Determining the clinical and subclinical characteristics related to the recurrence status in patients with a thyroid carcinoma has great significance for prognosis, prediction of recurrence and monitoring of treatment outcomes. This study aimed to determine the association between recurrence rate and some characteristics in patients with thyroid carcinoma. Patients and Methods: The study was conducted by descriptive method with longitudinal follow-up on 102 thyroid carcinoma patients at 103 Military Hospital, Hanoi, Vietnam, from July 2013 to December 2016. Results: Univariate analysis showed that there was a relationship between the recurrence characteristics in the studied patients and the characteristics of lymph node metastasis (P = 0.026; OR = 15; 95% CI = 1.4–163.2) and BRAF V600E mutation status (P = 0.01; OR = 3.41; 95% CI = 1.31–8.88). When analysing the multivariable Logistic regression model, there was a positive correlation between the occurrence of BRAF V600E gene mutation (P = 0.032; OR = 17.649; 95% CI = 1.290–241.523) and male sex (P = 0.036; OR = 12.788; 95% CI = 1.185–137.961) and the occurrence of recurrence in study patients. The mean time to relapse was earlier in male patients than in female patients (P = 0.02). The mean time to relapse in patients with the BRAF V600E mutation (31.81 ± 1.14 months) was shorter than the mean time to relapse in the group without the mutation (57.82 ± 2.08 months) (P = 0.01). The group of patients with mutations in the BRAF V600E gene increased the risk of recurrence compared with the group without the mutation (HR = 9.14, P = 0.04). Conclusion: There is a positive correlation between recurrence and masculinity, lymph node metastasis and the occurrence of BRAF V600E mutations in thyroid carcinoma patients. |
| first_indexed | 2024-03-07T23:00:44Z |
| format | Article |
| id | doaj.art-fd6b55ce7c9f4fc283615c7ff71ed9ac |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-03-07T23:00:44Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-fd6b55ce7c9f4fc283615c7ff71ed9ac2024-02-22T14:51:33ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102023-01-0127654455110.4103/ijem.ijem_134_23Relationship of recurrence rate with some characteristics in patients with thyroid carcinomaTri D M. BuiChi D P. BuiHiep T BuiTrung H NguyenMinh D TongDung T N. NguyenThanh D BuiViet Q TranHiep T NguyenBackground: Determining the clinical and subclinical characteristics related to the recurrence status in patients with a thyroid carcinoma has great significance for prognosis, prediction of recurrence and monitoring of treatment outcomes. This study aimed to determine the association between recurrence rate and some characteristics in patients with thyroid carcinoma. Patients and Methods: The study was conducted by descriptive method with longitudinal follow-up on 102 thyroid carcinoma patients at 103 Military Hospital, Hanoi, Vietnam, from July 2013 to December 2016. Results: Univariate analysis showed that there was a relationship between the recurrence characteristics in the studied patients and the characteristics of lymph node metastasis (P = 0.026; OR = 15; 95% CI = 1.4–163.2) and BRAF V600E mutation status (P = 0.01; OR = 3.41; 95% CI = 1.31–8.88). When analysing the multivariable Logistic regression model, there was a positive correlation between the occurrence of BRAF V600E gene mutation (P = 0.032; OR = 17.649; 95% CI = 1.290–241.523) and male sex (P = 0.036; OR = 12.788; 95% CI = 1.185–137.961) and the occurrence of recurrence in study patients. The mean time to relapse was earlier in male patients than in female patients (P = 0.02). The mean time to relapse in patients with the BRAF V600E mutation (31.81 ± 1.14 months) was shorter than the mean time to relapse in the group without the mutation (57.82 ± 2.08 months) (P = 0.01). The group of patients with mutations in the BRAF V600E gene increased the risk of recurrence compared with the group without the mutation (HR = 9.14, P = 0.04). Conclusion: There is a positive correlation between recurrence and masculinity, lymph node metastasis and the occurrence of BRAF V600E mutations in thyroid carcinoma patients.http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=6;spage=544;epage=551;aulast=M.braf v600e mutationlymph node metastasisrecurrence ratethyroid carcinoma |
| spellingShingle | Tri D M. Bui Chi D P. Bui Hiep T Bui Trung H Nguyen Minh D Tong Dung T N. Nguyen Thanh D Bui Viet Q Tran Hiep T Nguyen Relationship of recurrence rate with some characteristics in patients with thyroid carcinoma Indian Journal of Endocrinology and Metabolism braf v600e mutation lymph node metastasis recurrence rate thyroid carcinoma |
| title | Relationship of recurrence rate with some characteristics in patients with thyroid carcinoma |
| title_full | Relationship of recurrence rate with some characteristics in patients with thyroid carcinoma |
| title_fullStr | Relationship of recurrence rate with some characteristics in patients with thyroid carcinoma |
| title_full_unstemmed | Relationship of recurrence rate with some characteristics in patients with thyroid carcinoma |
| title_short | Relationship of recurrence rate with some characteristics in patients with thyroid carcinoma |
| title_sort | relationship of recurrence rate with some characteristics in patients with thyroid carcinoma |
| topic | braf v600e mutation lymph node metastasis recurrence rate thyroid carcinoma |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=6;spage=544;epage=551;aulast=M. |
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