Study Protocol: The Heart and Brain Study
BackgroundIt is well-established that what is good for the heart is good for the brain. Vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele increase the risk of developing both cardiovascular disease and dementia. However, t...
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.643725/full |
| _version_ | 1818965029500747776 |
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| author | Sana Suri Sana Suri Daniel Bulte Scott T. Chiesa Klaus P. Ebmeier Peter Jezzard Peter Jezzard Sebastian W. Rieger Sebastian W. Rieger Sebastian W. Rieger Sebastian W. Rieger Jemma E. Pitt Jemma E. Pitt Ludovica Griffanti Ludovica Griffanti Ludovica Griffanti Thomas W. Okell Thomas W. Okell Martin Craig Martin Craig Martin Craig Michael A. Chappell Michael A. Chappell Michael A. Chappell Nicholas P. Blockley Mika Kivimäki Archana Singh-Manoux Ashraf W. Khir Alun D. Hughes John E. Deanfield Daria E. A. Jensen Daria E. A. Jensen Sebastian F. Green Veronika Sigutova Michelle G. Jansen Enikő Zsoldos Enikő Zsoldos Clare E. Mackay Clare E. Mackay |
| author_facet | Sana Suri Sana Suri Daniel Bulte Scott T. Chiesa Klaus P. Ebmeier Peter Jezzard Peter Jezzard Sebastian W. Rieger Sebastian W. Rieger Sebastian W. Rieger Sebastian W. Rieger Jemma E. Pitt Jemma E. Pitt Ludovica Griffanti Ludovica Griffanti Ludovica Griffanti Thomas W. Okell Thomas W. Okell Martin Craig Martin Craig Martin Craig Michael A. Chappell Michael A. Chappell Michael A. Chappell Nicholas P. Blockley Mika Kivimäki Archana Singh-Manoux Ashraf W. Khir Alun D. Hughes John E. Deanfield Daria E. A. Jensen Daria E. A. Jensen Sebastian F. Green Veronika Sigutova Michelle G. Jansen Enikő Zsoldos Enikő Zsoldos Clare E. Mackay Clare E. Mackay |
| author_sort | Sana Suri |
| collection | DOAJ |
| description | BackgroundIt is well-established that what is good for the heart is good for the brain. Vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele increase the risk of developing both cardiovascular disease and dementia. However, the mechanisms underlying the heart–brain association remain unclear. Recent evidence suggests that impairments in vascular phenotypes and cerebrovascular reactivity (CVR) may play an important role in cognitive decline. The Heart and Brain Study combines state-of-the-art vascular ultrasound, cerebrovascular magnetic resonance imaging (MRI) and cognitive testing in participants of the long-running Whitehall II Imaging cohort to examine these processes together. This paper describes the study protocol, data pre-processing and overarching objectives.Methods and DesignThe 775 participants of the Whitehall II Imaging cohort, aged 65 years or older in 2019, have received clinical and vascular risk assessments at 5-year-intervals since 1985, as well as a 3T brain MRI scan and neuropsychological tests between 2012 and 2016 (Whitehall II Wave MRI-1). Approximately 25% of this cohort are selected for the Heart and Brain Study, which involves a single testing session at the University of Oxford (Wave MRI-2). Between 2019 and 2023, participants will undergo ultrasound scans of the ascending aorta and common carotid arteries, measures of central and peripheral blood pressure, and 3T MRI scans to measure CVR in response to 5% carbon dioxide in air, vessel-selective cerebral blood flow (CBF), and cerebrovascular lesions. The structural and diffusion MRI scans and neuropsychological battery conducted at Wave MRI-1 will also be repeated. Using this extensive life-course data, the Heart and Brain Study will examine how 30-year trajectories of vascular risk throughout midlife (40–70 years) affect vascular phenotypes, cerebrovascular health, longitudinal brain atrophy and cognitive decline at older ages.DiscussionThe study will generate one of the most comprehensive datasets to examine the longitudinal determinants of the heart–brain association. It will evaluate novel physiological processes in order to describe the optimal window for managing vascular risk in order to delay cognitive decline. Ultimately, the Heart and Brain Study will inform strategies to identify at-risk individuals for targeted interventions to prevent or delay dementia. |
| first_indexed | 2024-12-20T13:10:31Z |
| format | Article |
| id | doaj.art-fd6cdf6493f34421b7162fca5d4a66a0 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T13:10:31Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-fd6cdf6493f34421b7162fca5d4a66a02022-12-21T19:39:41ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-03-011210.3389/fphys.2021.643725643725Study Protocol: The Heart and Brain StudySana Suri0Sana Suri1Daniel Bulte2Scott T. Chiesa3Klaus P. Ebmeier4Peter Jezzard5Peter Jezzard6Sebastian W. Rieger7Sebastian W. Rieger8Sebastian W. Rieger9Sebastian W. Rieger10Jemma E. Pitt11Jemma E. Pitt12Ludovica Griffanti13Ludovica Griffanti14Ludovica Griffanti15Thomas W. Okell16Thomas W. Okell17Martin Craig18Martin Craig19Martin Craig20Michael A. Chappell21Michael A. Chappell22Michael A. Chappell23Nicholas P. Blockley24Mika Kivimäki25Archana Singh-Manoux26Ashraf W. Khir27Alun D. Hughes28John E. Deanfield29Daria E. A. Jensen30Daria E. A. Jensen31Sebastian F. Green32Veronika Sigutova33Michelle G. Jansen34Enikő Zsoldos35Enikő Zsoldos36Clare E. Mackay37Clare E. Mackay38Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United KingdomOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United KingdomOxford Institute of Biomedical Engineering, University of Oxford, Oxford, United KingdomInstitute of Cardiovascular Science, University College London, London, United KingdomDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United KingdomFMRIB Centre, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United KingdomNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United KingdomOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United KingdomFMRIB Centre, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United KingdomNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United KingdomOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United KingdomDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United KingdomOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United KingdomFMRIB Centre, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United KingdomFMRIB Centre, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United KingdomNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomRadiological Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United KingdomSir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United KingdomNottingham Biomedical Research Centre, Queens Medical Centre, University of Nottingham, Nottingham, United KingdomRadiological Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United KingdomSir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United KingdomNottingham Biomedical Research Centre, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom0School of Life Sciences, University of Nottingham, Nottingham, United Kingdom1Department of Epidemiology and Public Health, University College London, London, United Kingdom2Inserm U1153, Epidemiology of Ageing and Neurodegenerative Diseases, Paris, France3Mechanical Engineering, Brunel University London, Uxbridge, United Kingdom4MRC Unit for Lifelong Health and Ageing, Institute of Cardiovascular Science, University College London, London, United KingdomInstitute of Cardiovascular Science, University College London, London, United KingdomDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United KingdomOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United KingdomDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United KingdomDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom5Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, NetherlandsDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United KingdomOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United KingdomDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United KingdomOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United KingdomBackgroundIt is well-established that what is good for the heart is good for the brain. Vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele increase the risk of developing both cardiovascular disease and dementia. However, the mechanisms underlying the heart–brain association remain unclear. Recent evidence suggests that impairments in vascular phenotypes and cerebrovascular reactivity (CVR) may play an important role in cognitive decline. The Heart and Brain Study combines state-of-the-art vascular ultrasound, cerebrovascular magnetic resonance imaging (MRI) and cognitive testing in participants of the long-running Whitehall II Imaging cohort to examine these processes together. This paper describes the study protocol, data pre-processing and overarching objectives.Methods and DesignThe 775 participants of the Whitehall II Imaging cohort, aged 65 years or older in 2019, have received clinical and vascular risk assessments at 5-year-intervals since 1985, as well as a 3T brain MRI scan and neuropsychological tests between 2012 and 2016 (Whitehall II Wave MRI-1). Approximately 25% of this cohort are selected for the Heart and Brain Study, which involves a single testing session at the University of Oxford (Wave MRI-2). Between 2019 and 2023, participants will undergo ultrasound scans of the ascending aorta and common carotid arteries, measures of central and peripheral blood pressure, and 3T MRI scans to measure CVR in response to 5% carbon dioxide in air, vessel-selective cerebral blood flow (CBF), and cerebrovascular lesions. The structural and diffusion MRI scans and neuropsychological battery conducted at Wave MRI-1 will also be repeated. Using this extensive life-course data, the Heart and Brain Study will examine how 30-year trajectories of vascular risk throughout midlife (40–70 years) affect vascular phenotypes, cerebrovascular health, longitudinal brain atrophy and cognitive decline at older ages.DiscussionThe study will generate one of the most comprehensive datasets to examine the longitudinal determinants of the heart–brain association. It will evaluate novel physiological processes in order to describe the optimal window for managing vascular risk in order to delay cognitive decline. Ultimately, the Heart and Brain Study will inform strategies to identify at-risk individuals for targeted interventions to prevent or delay dementia.https://www.frontiersin.org/articles/10.3389/fphys.2021.643725/fullageingMRIcerebrovascular reactivitycognitiondementia preventionlongitudinal cohort |
| spellingShingle | Sana Suri Sana Suri Daniel Bulte Scott T. Chiesa Klaus P. Ebmeier Peter Jezzard Peter Jezzard Sebastian W. Rieger Sebastian W. Rieger Sebastian W. Rieger Sebastian W. Rieger Jemma E. Pitt Jemma E. Pitt Ludovica Griffanti Ludovica Griffanti Ludovica Griffanti Thomas W. Okell Thomas W. Okell Martin Craig Martin Craig Martin Craig Michael A. Chappell Michael A. Chappell Michael A. Chappell Nicholas P. Blockley Mika Kivimäki Archana Singh-Manoux Ashraf W. Khir Alun D. Hughes John E. Deanfield Daria E. A. Jensen Daria E. A. Jensen Sebastian F. Green Veronika Sigutova Michelle G. Jansen Enikő Zsoldos Enikő Zsoldos Clare E. Mackay Clare E. Mackay Study Protocol: The Heart and Brain Study Frontiers in Physiology ageing MRI cerebrovascular reactivity cognition dementia prevention longitudinal cohort |
| title | Study Protocol: The Heart and Brain Study |
| title_full | Study Protocol: The Heart and Brain Study |
| title_fullStr | Study Protocol: The Heart and Brain Study |
| title_full_unstemmed | Study Protocol: The Heart and Brain Study |
| title_short | Study Protocol: The Heart and Brain Study |
| title_sort | study protocol the heart and brain study |
| topic | ageing MRI cerebrovascular reactivity cognition dementia prevention longitudinal cohort |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.643725/full |
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