Anesthetic isoflurane increases phosphorylated tau levels mediated by caspase activation and Aβ generation.

Anesthetic isoflurane increases phosphorylated tau levels mediated by caspase activation and Aβ generation.

Anesthetic isoflurane has been shown to promote Alzheimer's disease (AD) neuropathogenesis by inducing caspase activation and accumulation of β-amyloid (Aβ). Phosphorylation of tau protein is another important feature of AD neuropathogenesis. However, the effects of isoflurane on phosphorylated...

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Bibliographic Details
Main Authors: Yuanlin Dong, Xu Wu, Zhipeng Xu, Yiying Zhang, Zhongcong Xie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3379981?pdf=render

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