Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern China
Abstract Objectives Silicosis people are at high risk of developing pulmonary tuberculosis. Whether silica exposure increases the likelihood of latent tuberculosis infection (LTBI) was not well understood, and potential factors involved in LTBI risk among silicosis people were not evaluated before....
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-024-02985-z |
| _version_ | 1827277394663178240 |
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| author | Xinsong Hu Cheng Chen Qianqian Gao Lang Zhou Yan Shao Guoli Li Honghuan Song Qiao Liu Lei Han Limei Zhu |
| author_facet | Xinsong Hu Cheng Chen Qianqian Gao Lang Zhou Yan Shao Guoli Li Honghuan Song Qiao Liu Lei Han Limei Zhu |
| author_sort | Xinsong Hu |
| collection | DOAJ |
| description | Abstract Objectives Silicosis people are at high risk of developing pulmonary tuberculosis. Whether silica exposure increases the likelihood of latent tuberculosis infection (LTBI) was not well understood, and potential factors involved in LTBI risk among silicosis people were not evaluated before. Thus, LTBI among silicosis people and potential risk factors for LTBI among silicosis people were evaluated in this study. Methods A cross-sectional study was undertaken for 130 miner workers with silicosis. The QFT-GIT was performed for LTBI detection. Results The LTBI was high to 31.6% (36/114) for silicosis participants, and 13.1% (13/99) had a history of tuberculosis. Drinking was associated with LTBI risk (OR = 6.92, 95%CI, 1.47–32.66, P = 0.015). Meanwhile, tunneling work was associated with an increased risk of LTBI compared with other mining occupations (OR = 3.91,95%CI,1.20–12.70, P = 0.024). Conclusions The LTBI rate of silicosis participants was high and more than 10% had a history of tuberculosis. Drinking alcohol and tunneling were independent risk factors for LTBI in silicosis participants. |
| first_indexed | 2024-04-24T07:20:21Z |
| format | Article |
| id | doaj.art-fd6fbb8aea3e4b80bdacc08646b2f4db |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-24T07:20:21Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-fd6fbb8aea3e4b80bdacc08646b2f4db2024-04-21T11:07:31ZengBMCBMC Pulmonary Medicine1471-24662024-04-012411610.1186/s12890-024-02985-zLatent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern ChinaXinsong Hu0Cheng Chen1Qianqian Gao2Lang Zhou3Yan Shao4Guoli Li5Honghuan Song6Qiao Liu7Lei Han8Limei Zhu9School of Public Health, Nanjing Medical UniversityDepartment of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu ProvinceDepartment of Occupational Disease Prevention, Center for Disease Control and Prevention of Jiangsu ProvinceDepartment of Occupational Disease Prevention, Center for Disease Control and Prevention of Jiangsu ProvinceDepartment of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu ProvinceDepartment of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu ProvinceDepartment of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu ProvinceDepartment of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu ProvinceDepartment of Occupational Disease Prevention, Center for Disease Control and Prevention of Jiangsu ProvinceSchool of Public Health, Nanjing Medical UniversityAbstract Objectives Silicosis people are at high risk of developing pulmonary tuberculosis. Whether silica exposure increases the likelihood of latent tuberculosis infection (LTBI) was not well understood, and potential factors involved in LTBI risk among silicosis people were not evaluated before. Thus, LTBI among silicosis people and potential risk factors for LTBI among silicosis people were evaluated in this study. Methods A cross-sectional study was undertaken for 130 miner workers with silicosis. The QFT-GIT was performed for LTBI detection. Results The LTBI was high to 31.6% (36/114) for silicosis participants, and 13.1% (13/99) had a history of tuberculosis. Drinking was associated with LTBI risk (OR = 6.92, 95%CI, 1.47–32.66, P = 0.015). Meanwhile, tunneling work was associated with an increased risk of LTBI compared with other mining occupations (OR = 3.91,95%CI,1.20–12.70, P = 0.024). Conclusions The LTBI rate of silicosis participants was high and more than 10% had a history of tuberculosis. Drinking alcohol and tunneling were independent risk factors for LTBI in silicosis participants.https://doi.org/10.1186/s12890-024-02985-zTuberculosisLatent tuberculosis infectionSilicosisRisk factors |
| spellingShingle | Xinsong Hu Cheng Chen Qianqian Gao Lang Zhou Yan Shao Guoli Li Honghuan Song Qiao Liu Lei Han Limei Zhu Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern China BMC Pulmonary Medicine Tuberculosis Latent tuberculosis infection Silicosis Risk factors |
| title | Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern China |
| title_full | Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern China |
| title_fullStr | Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern China |
| title_full_unstemmed | Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern China |
| title_short | Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern China |
| title_sort | latent tuberculosis infection and infection associated risk factors for miner workers with silicosis in eastern china |
| topic | Tuberculosis Latent tuberculosis infection Silicosis Risk factors |
| url | https://doi.org/10.1186/s12890-024-02985-z |
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