Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1

Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1

Optimal phototransduction requires separation of the avascular photoreceptor layer from the adjacent vascularized inner retina and choroid. Breakdown of peri-photoreceptor vascular demarcation leads to retinal angiomatous proliferation or choroidal neovascularization, two variants of vascular invasi...

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Bibliographic Details
Main Authors: Ling Luo, Hironori Uehara, Xiaohui Zhang, Subrata K Das, Thomas Olsen, Derick Holt, Jacquelyn M Simonis, Kyle Jackman, Nirbhai Singh, Tadashi R Miya, Wei Huang, Faisal Ahmed, Ana Bastos-Carvalho, Yun Zheng Le, Christina Mamalis, Vince A Chiodo, William W Hauswirth, Judit Baffi, Pedro M Lacal, Angela Orecchia, Napoleone Ferrara, Guangping Gao, Kim Young-hee, Yingbin Fu, Leah Owen, Romulo Albuquerque, Wolfgang Baehr, Kirk Thomas, Dean Y Li, Kakarla V Chalam, Masabumi Shibuya, Salvatore Grisanti, David J Wilson, Jayakrishna Ambati, Balamurali K Ambati
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-06-01
Series:eLife
Subjects:
age-related macular degeneration
photoreceptor metabolism
retinal vasculature
soluble VEGF receptor-1
vascular demarcation
transgenic model
Online Access:https://elifesciences.org/articles/00324

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