Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP

Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP

Selective elimination of unwanted synapses is vital for the precise formation of neuronal circuits during development, but the underlying mechanisms remain unclear. Using inositol 1,4,5-trisphosphate receptor type 2 knockout (Itpr2−/−) mice to specifically disturb somatic Ca2+ signaling in astrocyte...

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Bibliographic Details
Main Authors: Junhua Yang, Hongbin Yang, Yali Liu, Xia Li, Liming Qin, Huifang Lou, Shumin Duan, Hao Wang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-04-01
Series:eLife
Subjects:
synapse elimination
astrocytes
ATP
purinergic signaling
Online Access:https://elifesciences.org/articles/15043

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