Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment

Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment

Preeclampsia is a pregnancy-specific disorder involving placental abnormalities. Elevated placental Sialic acid immunoglobulin-like lectin (Siglec)-6 expression has been correlated with preeclampsia. Siglec-6 is a transmembrane receptor, expressed predominantly by the trophoblast cells in the human...

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Bibliographic Details
Main Authors: Adrianne L. Stefanski, Michael D. Renecle, Anita Kramer, Shilpi Sehgal, Purnima Narasimhan, Kristen K. Rumer, Virginia D Winn
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
Siglec-6
trophoblast
preeclampsia
phosphorylation
signal transduction
Online Access:https://www.mdpi.com/2073-4409/11/21/3427

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