Clinical features of bone metastasis for differentiated thyroid carcinoma: A study of 21 patients from a Tunisian center
Introduction: The differentiated thyroid cancers have a good prognosis unless the presence of metastasis. These distant metastases, especially in bone, are a major cause of impaired quality of life and death requiring intensive management. The aim of our work was to study the patients′ data, the dis...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2014-01-01
|
Series: | Indian Journal of Endocrinology and Metabolism |
Subjects: | |
Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=2;spage=185;epage=190;aulast=Kallel |
_version_ | 1811273035753193472 |
---|---|
author | Faouzi Kallel Fatma Hamza Salma Charfeddine Wissem Amouri Issam Jardak Abdelmonem Ghorbel Fadhel Guermazi |
author_facet | Faouzi Kallel Fatma Hamza Salma Charfeddine Wissem Amouri Issam Jardak Abdelmonem Ghorbel Fadhel Guermazi |
author_sort | Faouzi Kallel |
collection | DOAJ |
description | Introduction: The differentiated thyroid cancers have a good prognosis unless the presence of metastasis. These distant metastases, especially in bone, are a major cause of impaired quality of life and death requiring intensive management. The aim of our work was to study the patients′ data, the disease characteristics and to analyze the therapeutic management of these patients. Results: This study concerned a cohort of 21 patients treated for differentiated thyroid cancer during the period from 1995 to 2011. Eighteen of our patients were aged over 45 years. A majority of them had follicular carcinoma. Bone metastases were often multiple and located at the axial skeleton. They were associated with other types of metastases, especially lung metastasis. A majority of patients received 131I treatment, following surgery or external beam radiotherapy for a palliative purpose. Overall survival was 65% at 5 years and 49% at 10 years. A long-term survival was achieved in 10% of the patients benefiting from a multidisciplinary care adapted to each case. Conclusion: Bone metastases often have a pejorative turning in the natural history of differentiated thyroid cancers. The right selection of individuals with better prognosis, for whom more aggressive curative treatment was indicated, requires a better understanding of the features of bone involvement. |
first_indexed | 2024-04-12T22:50:55Z |
format | Article |
id | doaj.art-fd72910f455c485f9e43ff1d2f71f148 |
institution | Directory Open Access Journal |
issn | 2230-8210 2230-9500 |
language | English |
last_indexed | 2024-04-12T22:50:55Z |
publishDate | 2014-01-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | Indian Journal of Endocrinology and Metabolism |
spelling | doaj.art-fd72910f455c485f9e43ff1d2f71f1482022-12-22T03:13:21ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002014-01-0118218519010.4103/2230-8210.129109Clinical features of bone metastasis for differentiated thyroid carcinoma: A study of 21 patients from a Tunisian centerFaouzi KallelFatma HamzaSalma CharfeddineWissem AmouriIssam JardakAbdelmonem GhorbelFadhel GuermaziIntroduction: The differentiated thyroid cancers have a good prognosis unless the presence of metastasis. These distant metastases, especially in bone, are a major cause of impaired quality of life and death requiring intensive management. The aim of our work was to study the patients′ data, the disease characteristics and to analyze the therapeutic management of these patients. Results: This study concerned a cohort of 21 patients treated for differentiated thyroid cancer during the period from 1995 to 2011. Eighteen of our patients were aged over 45 years. A majority of them had follicular carcinoma. Bone metastases were often multiple and located at the axial skeleton. They were associated with other types of metastases, especially lung metastasis. A majority of patients received 131I treatment, following surgery or external beam radiotherapy for a palliative purpose. Overall survival was 65% at 5 years and 49% at 10 years. A long-term survival was achieved in 10% of the patients benefiting from a multidisciplinary care adapted to each case. Conclusion: Bone metastases often have a pejorative turning in the natural history of differentiated thyroid cancers. The right selection of individuals with better prognosis, for whom more aggressive curative treatment was indicated, requires a better understanding of the features of bone involvement.http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=2;spage=185;epage=190;aulast=KallelBone metastasesdifferentiated thyroid canceriodine-131thyroglobulin |
spellingShingle | Faouzi Kallel Fatma Hamza Salma Charfeddine Wissem Amouri Issam Jardak Abdelmonem Ghorbel Fadhel Guermazi Clinical features of bone metastasis for differentiated thyroid carcinoma: A study of 21 patients from a Tunisian center Indian Journal of Endocrinology and Metabolism Bone metastases differentiated thyroid cancer iodine-131 thyroglobulin |
title | Clinical features of bone metastasis for differentiated thyroid carcinoma: A study of 21 patients from a Tunisian center |
title_full | Clinical features of bone metastasis for differentiated thyroid carcinoma: A study of 21 patients from a Tunisian center |
title_fullStr | Clinical features of bone metastasis for differentiated thyroid carcinoma: A study of 21 patients from a Tunisian center |
title_full_unstemmed | Clinical features of bone metastasis for differentiated thyroid carcinoma: A study of 21 patients from a Tunisian center |
title_short | Clinical features of bone metastasis for differentiated thyroid carcinoma: A study of 21 patients from a Tunisian center |
title_sort | clinical features of bone metastasis for differentiated thyroid carcinoma a study of 21 patients from a tunisian center |
topic | Bone metastases differentiated thyroid cancer iodine-131 thyroglobulin |
url | http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=2;spage=185;epage=190;aulast=Kallel |
work_keys_str_mv | AT faouzikallel clinicalfeaturesofbonemetastasisfordifferentiatedthyroidcarcinomaastudyof21patientsfromatunisiancenter AT fatmahamza clinicalfeaturesofbonemetastasisfordifferentiatedthyroidcarcinomaastudyof21patientsfromatunisiancenter AT salmacharfeddine clinicalfeaturesofbonemetastasisfordifferentiatedthyroidcarcinomaastudyof21patientsfromatunisiancenter AT wissemamouri clinicalfeaturesofbonemetastasisfordifferentiatedthyroidcarcinomaastudyof21patientsfromatunisiancenter AT issamjardak clinicalfeaturesofbonemetastasisfordifferentiatedthyroidcarcinomaastudyof21patientsfromatunisiancenter AT abdelmonemghorbel clinicalfeaturesofbonemetastasisfordifferentiatedthyroidcarcinomaastudyof21patientsfromatunisiancenter AT fadhelguermazi clinicalfeaturesofbonemetastasisfordifferentiatedthyroidcarcinomaastudyof21patientsfromatunisiancenter |