Investigating the Effect of Zinc Chloride on Control of Liver Hemorrhage; an Animal Model Study
Background: The control of parenchymal hemorrhage, especially in liver parenchyma, despite surgical science progresses, is still one of the challenges surgeons face saving the patients’ lives; and there is a research challenge between the researchers in this field to introduce a more effective metho...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2015-01-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/3989 |
| _version_ | 1797718580417003520 |
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| author | Saeed Nouri Mohammad Reza Sharif |
| author_facet | Saeed Nouri Mohammad Reza Sharif |
| author_sort | Saeed Nouri |
| collection | DOAJ |
| description | Background: The control of parenchymal hemorrhage, especially in liver parenchyma, despite surgical science progresses, is still one of the challenges surgeons face saving the patients’ lives; and there is a research challenge between the researchers in this field to introduce a more effective method. This study aimed to determine the hemostatic effect of zinc chloride on controlling the bleeding from liver parenchymal tissue.
Methods: In this animal model study, 60 male Wistar rats were used. An incision with length of 2 and depth of 0.5 cm was made on each mouse’s liver and the hemostasis time was measured using zinc chloride different concentrations (5%, 10%, 15%, 25%, and 50%) and the control method (i.e. control of bleeding via suturing).
Findings: In all the groups, complete hemostasis occurred; the hemostasis times of zinc chloride concentration groups were significantly less than that of the control group (P < 0.001). At concentrations of 5%, 10% and 15% of zinc chloride and suture group, pathological grade one was seen. In addition, in the 25% and 50% zinc chloride groups, pathological grade two was the most common grade (70% and 80%, respectively).
Conclusion: Zinc chloride is an effective hemostatic agent in controlling liver parenchymal tissue hemorrhage in an animal model; it can control the liver bleeding, also at the lowest concentration (5%). |
| first_indexed | 2024-03-12T08:52:27Z |
| format | Article |
| id | doaj.art-fd74ba6177364236beb05438585a0c5f |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:52:27Z |
| publishDate | 2015-01-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-fd74ba6177364236beb05438585a0c5f2023-09-02T16:17:45ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2015-01-0132308184518541728Investigating the Effect of Zinc Chloride on Control of Liver Hemorrhage; an Animal Model StudySaeed Nouri0Mohammad Reza Sharif1General Practitioner, Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranAssociate Professor, Trauma Research Center, Kashan University of Medical Sciences, Kashan, IranBackground: The control of parenchymal hemorrhage, especially in liver parenchyma, despite surgical science progresses, is still one of the challenges surgeons face saving the patients’ lives; and there is a research challenge between the researchers in this field to introduce a more effective method. This study aimed to determine the hemostatic effect of zinc chloride on controlling the bleeding from liver parenchymal tissue. Methods: In this animal model study, 60 male Wistar rats were used. An incision with length of 2 and depth of 0.5 cm was made on each mouse’s liver and the hemostasis time was measured using zinc chloride different concentrations (5%, 10%, 15%, 25%, and 50%) and the control method (i.e. control of bleeding via suturing). Findings: In all the groups, complete hemostasis occurred; the hemostasis times of zinc chloride concentration groups were significantly less than that of the control group (P < 0.001). At concentrations of 5%, 10% and 15% of zinc chloride and suture group, pathological grade one was seen. In addition, in the 25% and 50% zinc chloride groups, pathological grade two was the most common grade (70% and 80%, respectively). Conclusion: Zinc chloride is an effective hemostatic agent in controlling liver parenchymal tissue hemorrhage in an animal model; it can control the liver bleeding, also at the lowest concentration (5%).http://jims.mui.ac.ir/index.php/jims/article/view/3989HemostasisZinc chlorideLiver |
| spellingShingle | Saeed Nouri Mohammad Reza Sharif Investigating the Effect of Zinc Chloride on Control of Liver Hemorrhage; an Animal Model Study مجله دانشکده پزشکی اصفهان Hemostasis Zinc chloride Liver |
| title | Investigating the Effect of Zinc Chloride on Control of Liver Hemorrhage; an Animal Model Study |
| title_full | Investigating the Effect of Zinc Chloride on Control of Liver Hemorrhage; an Animal Model Study |
| title_fullStr | Investigating the Effect of Zinc Chloride on Control of Liver Hemorrhage; an Animal Model Study |
| title_full_unstemmed | Investigating the Effect of Zinc Chloride on Control of Liver Hemorrhage; an Animal Model Study |
| title_short | Investigating the Effect of Zinc Chloride on Control of Liver Hemorrhage; an Animal Model Study |
| title_sort | investigating the effect of zinc chloride on control of liver hemorrhage an animal model study |
| topic | Hemostasis Zinc chloride Liver |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/3989 |
| work_keys_str_mv | AT saeednouri investigatingtheeffectofzincchlorideoncontrolofliverhemorrhageananimalmodelstudy AT mohammadrezasharif investigatingtheeffectofzincchlorideoncontrolofliverhemorrhageananimalmodelstudy |