Acute Ketamine Facilitates Fear Memory Extinction in a Rat Model of PTSD Along With Restoring Glutamatergic Alterations and Dendritic Atrophy in the Prefrontal Cortex

Acute Ketamine Facilitates Fear Memory Extinction in a Rat Model of PTSD Along With Restoring Glutamatergic Alterations and Dendritic Atrophy in the Prefrontal Cortex

Stress represents a major risk factor for psychiatric disorders, including post-traumatic stress disorder (PTSD). Recently, we dissected the destabilizing effects of acute stress on the excitatory glutamate system in the prefrontal cortex (PFC). Here, we assessed the effects of single subanesthetic...

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Bibliographic Details
Main Authors: Nathalie Sala, Caterina Paoli, Tiziana Bonifacino, Jessica Mingardi, Emanuele Schiavon, Luca La Via, Marco Milanese, Paolo Tornese, Ashok K. Datusalia, Jessica Rosa, Roberta Facchinetti, Giulia Frumento, Giulia Carini, Floramarida Salerno Scarzella, Caterina Scuderi, Lia Forti, Alessandro Barbon, Giambattista Bonanno, Maurizio Popoli, Laura Musazzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
acute stress
ketamine
PTSD
prefrontal cortex (PFC)
glutamate transmission
dendritic arborization
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.759626/full

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