Research progress on the pathogenesis of Graves’ ophthalmopathy: Based on immunity, noncoding RNA and exosomes
Graves’ ophthalmopathy (GO), also known as thyroid-associated ophthalmopathy, is a common potentially vision-threatening organ-specific autoimmune disease and the most common extrathyroidal manifestation of Graves’ disease. It can happen to those who have hyperthyroidism or euthyroidism. At present,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.952954/full |
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| author | Jingyi Zheng Jingyi Zheng Honghong Duan Sufang You Sufang You Bo Liang Yuping Chen Yuping Chen Huibin Huang |
| author_facet | Jingyi Zheng Jingyi Zheng Honghong Duan Sufang You Sufang You Bo Liang Yuping Chen Yuping Chen Huibin Huang |
| author_sort | Jingyi Zheng |
| collection | DOAJ |
| description | Graves’ ophthalmopathy (GO), also known as thyroid-associated ophthalmopathy, is a common potentially vision-threatening organ-specific autoimmune disease and the most common extrathyroidal manifestation of Graves’ disease. It can happen to those who have hyperthyroidism or euthyroidism. At present, the pathogenesis of GO has not been fully elucidated, and the majority of clinical treatments are symptomatic. Therefore, we are eager to discover any new therapeutic strategies that target the etiology of GO. To provide fresh ideas for the creation of new therapeutic techniques, this study primarily discusses the research state and progress of GO-related pathogenesis from the perspectives of GO’s cellular immunity, autoantigens, non-coding RNAs, and exosomes. |
| first_indexed | 2024-04-11T21:53:38Z |
| format | Article |
| id | doaj.art-fd796fda97444edbb591258c6109d413 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T21:53:38Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-fd796fda97444edbb591258c6109d4132022-12-22T04:01:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.952954952954Research progress on the pathogenesis of Graves’ ophthalmopathy: Based on immunity, noncoding RNA and exosomesJingyi Zheng0Jingyi Zheng1Honghong Duan2Sufang You3Sufang You4Bo Liang5Yuping Chen6Yuping Chen7Huibin Huang8The Second Clinical Medical College of Fujian Medical University, Quanzhou, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaThe Second Clinical Medical College of Fujian Medical University, Quanzhou, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaThe Second Clinical Medical College of Fujian Medical University, Quanzhou, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaGraves’ ophthalmopathy (GO), also known as thyroid-associated ophthalmopathy, is a common potentially vision-threatening organ-specific autoimmune disease and the most common extrathyroidal manifestation of Graves’ disease. It can happen to those who have hyperthyroidism or euthyroidism. At present, the pathogenesis of GO has not been fully elucidated, and the majority of clinical treatments are symptomatic. Therefore, we are eager to discover any new therapeutic strategies that target the etiology of GO. To provide fresh ideas for the creation of new therapeutic techniques, this study primarily discusses the research state and progress of GO-related pathogenesis from the perspectives of GO’s cellular immunity, autoantigens, non-coding RNAs, and exosomes.https://www.frontiersin.org/articles/10.3389/fimmu.2022.952954/fullGraves’ ophthalmopathycellular immunityautoantigennoncoding RNAexosomesbiologics |
| spellingShingle | Jingyi Zheng Jingyi Zheng Honghong Duan Sufang You Sufang You Bo Liang Yuping Chen Yuping Chen Huibin Huang Research progress on the pathogenesis of Graves’ ophthalmopathy: Based on immunity, noncoding RNA and exosomes Frontiers in Immunology Graves’ ophthalmopathy cellular immunity autoantigen noncoding RNA exosomes biologics |
| title | Research progress on the pathogenesis of Graves’ ophthalmopathy: Based on immunity, noncoding RNA and exosomes |
| title_full | Research progress on the pathogenesis of Graves’ ophthalmopathy: Based on immunity, noncoding RNA and exosomes |
| title_fullStr | Research progress on the pathogenesis of Graves’ ophthalmopathy: Based on immunity, noncoding RNA and exosomes |
| title_full_unstemmed | Research progress on the pathogenesis of Graves’ ophthalmopathy: Based on immunity, noncoding RNA and exosomes |
| title_short | Research progress on the pathogenesis of Graves’ ophthalmopathy: Based on immunity, noncoding RNA and exosomes |
| title_sort | research progress on the pathogenesis of graves ophthalmopathy based on immunity noncoding rna and exosomes |
| topic | Graves’ ophthalmopathy cellular immunity autoantigen noncoding RNA exosomes biologics |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.952954/full |
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