A Review on Bioactive Anthraquinone and Derivatives as the Regulators for ROS
Anthraquinones are bioactive natural products, which are often found in medicinal herbs. These compounds exert antioxidant-related pharmacological actions including neuroprotective effects, anti-inflammation, anticancer, hepatoprotective effects and anti-aging, etc. Considering the benefits from the...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/24/8139 |
| _version_ | 1797379889308893184 |
|---|---|
| author | Lihua Zhao Lin Zheng |
| author_facet | Lihua Zhao Lin Zheng |
| author_sort | Lihua Zhao |
| collection | DOAJ |
| description | Anthraquinones are bioactive natural products, which are often found in medicinal herbs. These compounds exert antioxidant-related pharmacological actions including neuroprotective effects, anti-inflammation, anticancer, hepatoprotective effects and anti-aging, etc. Considering the benefits from their pharmacological use, recently, there was an upsurge in the development and utilization of anthraquinones as reactive oxygen species (ROS) regulators. In this review, a deep discussion was carried out on their antioxidant activities and the structure-activity relationships. The antioxidant mechanisms and the chemistry behind the antioxidant activities of both natural and synthesized compounds were furtherly explored and demonstrated. Due to the specific chemical activity of ROS, antioxidants are essential for human health. Therefore, the development of reagents that regulate the imbalance between ROS formation and elimination should be more extensive and rational, and the exploration of antioxidant mechanisms of anthraquinones may provide new therapeutic tools and ideas for various diseases mediated by ROS. |
| first_indexed | 2024-03-08T20:30:31Z |
| format | Article |
| id | doaj.art-fd79b31f46084d4a949d3e0c9d724378 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-08T20:30:31Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fd79b31f46084d4a949d3e0c9d7243782023-12-22T14:27:59ZengMDPI AGMolecules1420-30492023-12-012824813910.3390/molecules28248139A Review on Bioactive Anthraquinone and Derivatives as the Regulators for ROSLihua Zhao0Lin Zheng1Tianjin Renai College, Tianjin 301636, ChinaCollege of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaAnthraquinones are bioactive natural products, which are often found in medicinal herbs. These compounds exert antioxidant-related pharmacological actions including neuroprotective effects, anti-inflammation, anticancer, hepatoprotective effects and anti-aging, etc. Considering the benefits from their pharmacological use, recently, there was an upsurge in the development and utilization of anthraquinones as reactive oxygen species (ROS) regulators. In this review, a deep discussion was carried out on their antioxidant activities and the structure-activity relationships. The antioxidant mechanisms and the chemistry behind the antioxidant activities of both natural and synthesized compounds were furtherly explored and demonstrated. Due to the specific chemical activity of ROS, antioxidants are essential for human health. Therefore, the development of reagents that regulate the imbalance between ROS formation and elimination should be more extensive and rational, and the exploration of antioxidant mechanisms of anthraquinones may provide new therapeutic tools and ideas for various diseases mediated by ROS.https://www.mdpi.com/1420-3049/28/24/8139natural anthraquinoneanthraquinone derivativesROSstructure-activity relationshipantioxidant mechanism |
| spellingShingle | Lihua Zhao Lin Zheng A Review on Bioactive Anthraquinone and Derivatives as the Regulators for ROS Molecules natural anthraquinone anthraquinone derivatives ROS structure-activity relationship antioxidant mechanism |
| title | A Review on Bioactive Anthraquinone and Derivatives as the Regulators for ROS |
| title_full | A Review on Bioactive Anthraquinone and Derivatives as the Regulators for ROS |
| title_fullStr | A Review on Bioactive Anthraquinone and Derivatives as the Regulators for ROS |
| title_full_unstemmed | A Review on Bioactive Anthraquinone and Derivatives as the Regulators for ROS |
| title_short | A Review on Bioactive Anthraquinone and Derivatives as the Regulators for ROS |
| title_sort | review on bioactive anthraquinone and derivatives as the regulators for ros |
| topic | natural anthraquinone anthraquinone derivatives ROS structure-activity relationship antioxidant mechanism |
| url | https://www.mdpi.com/1420-3049/28/24/8139 |
| work_keys_str_mv | AT lihuazhao areviewonbioactiveanthraquinoneandderivativesastheregulatorsforros AT linzheng areviewonbioactiveanthraquinoneandderivativesastheregulatorsforros AT lihuazhao reviewonbioactiveanthraquinoneandderivativesastheregulatorsforros AT linzheng reviewonbioactiveanthraquinoneandderivativesastheregulatorsforros |