The production of nanoliposomal system containing Ducrosia anethifolia (DC.) Boiss essential oil made by sonication and filtration methods
Background: Ducrosia anethifolia (DC.) Boiss is native to Iran and its essential oil has cytotoxic effects. Objective: Herbal Essences have limited application due to instability. In this research, nanoliposome containing Ducrosia essential oil has been studied for abundance and size distribution to...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2020-06-01
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| Series: | Journal of Medicinal Plants |
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| Online Access: | http://jmp.ir/article-1-2341-en.html |
| _version_ | 1819112639541805056 |
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| author | Shahrzad Salari Mehrdad Shamsaddini |
| author_facet | Shahrzad Salari Mehrdad Shamsaddini |
| author_sort | Shahrzad Salari |
| collection | DOAJ |
| description | Background: Ducrosia anethifolia (DC.) Boiss is native to Iran and its essential oil has cytotoxic effects. Objective: Herbal Essences have limited application due to instability. In this research, nanoliposome containing Ducrosia essential oil has been studied for abundance and size distribution to enhance the essential oil stability for use in drug delivery systems. Methods: Essential oil was prepared and GC-MS were used to identify the extracted compounds. Thin-film hydration method was then used to create small liposome loaded with the extract. Nano-liposomes were made by sonication and filtration methods with molar ratios 7:3, 3:2 and ratios of 3:1 V/V Essential oil to lipid phase. Results: The results showed that size of nanoparticles made by sonication method with molar ratios of 3:2 was 39.49 to 354.4 nm with 80.7 to 19.3 % abundance and PDI of 0.856 Encapsulation Efficiency 38% and size of liposomes prepared using filtration method was 269.8 nm with 100% abundance and PDI of 0.507 with Encapsulation Efficiency 34% and results of nanoliposomes made by sonication with molar ratios of 7:3 and ratios of 3:1 was 224.4 to 5330 nm with 93 to 7 % abundance and PDI of 0.229 with Encapsulation Efficiency 46%. The size of liposomes prepared using filtration was 358.9 nm with 100% abundance and PDI of 0.286 with Encapsulation Efficiency 43.5%. Conclusion: It is important to note that the nanoliposomes produced by the sonication are smaller than filtration for use in the liposomal nanoscale system and Encapsulation Efficiency nanoliposomes made by molar ratios 7:3 was more than 3:2 molar ratios. |
| first_indexed | 2024-12-22T04:16:42Z |
| format | Article |
| id | doaj.art-fd7dbfe1b3af4ed7979957ef1fa5a39e |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-22T04:16:42Z |
| publishDate | 2020-06-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-fd7dbfe1b3af4ed7979957ef1fa5a39e2022-12-21T18:39:24ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582020-06-011974229238The production of nanoliposomal system containing Ducrosia anethifolia (DC.) Boiss essential oil made by sonication and filtration methodsShahrzad Salari0Mehrdad Shamsaddini1 Biotechnology, Shahid Bahonar University of Kerman, Kerman, Iran Razi Vaccine and Serum Research Institute, Kerman, Iran Background: Ducrosia anethifolia (DC.) Boiss is native to Iran and its essential oil has cytotoxic effects. Objective: Herbal Essences have limited application due to instability. In this research, nanoliposome containing Ducrosia essential oil has been studied for abundance and size distribution to enhance the essential oil stability for use in drug delivery systems. Methods: Essential oil was prepared and GC-MS were used to identify the extracted compounds. Thin-film hydration method was then used to create small liposome loaded with the extract. Nano-liposomes were made by sonication and filtration methods with molar ratios 7:3, 3:2 and ratios of 3:1 V/V Essential oil to lipid phase. Results: The results showed that size of nanoparticles made by sonication method with molar ratios of 3:2 was 39.49 to 354.4 nm with 80.7 to 19.3 % abundance and PDI of 0.856 Encapsulation Efficiency 38% and size of liposomes prepared using filtration method was 269.8 nm with 100% abundance and PDI of 0.507 with Encapsulation Efficiency 34% and results of nanoliposomes made by sonication with molar ratios of 7:3 and ratios of 3:1 was 224.4 to 5330 nm with 93 to 7 % abundance and PDI of 0.229 with Encapsulation Efficiency 46%. The size of liposomes prepared using filtration was 358.9 nm with 100% abundance and PDI of 0.286 with Encapsulation Efficiency 43.5%. Conclusion: It is important to note that the nanoliposomes produced by the sonication are smaller than filtration for use in the liposomal nanoscale system and Encapsulation Efficiency nanoliposomes made by molar ratios 7:3 was more than 3:2 molar ratios.http://jmp.ir/article-1-2341-en.html<i>ducrosia anethifolia</i>essential oilgas chromatography coupled with mass spectrometer (gc-ms) nanoliposome |
| spellingShingle | Shahrzad Salari Mehrdad Shamsaddini The production of nanoliposomal system containing Ducrosia anethifolia (DC.) Boiss essential oil made by sonication and filtration methods Journal of Medicinal Plants <i>ducrosia anethifolia</i> essential oil gas chromatography coupled with mass spectrometer (gc-ms) nanoliposome |
| title | The production of nanoliposomal system containing Ducrosia anethifolia (DC.) Boiss essential oil made by sonication and filtration methods |
| title_full | The production of nanoliposomal system containing Ducrosia anethifolia (DC.) Boiss essential oil made by sonication and filtration methods |
| title_fullStr | The production of nanoliposomal system containing Ducrosia anethifolia (DC.) Boiss essential oil made by sonication and filtration methods |
| title_full_unstemmed | The production of nanoliposomal system containing Ducrosia anethifolia (DC.) Boiss essential oil made by sonication and filtration methods |
| title_short | The production of nanoliposomal system containing Ducrosia anethifolia (DC.) Boiss essential oil made by sonication and filtration methods |
| title_sort | production of nanoliposomal system containing ducrosia anethifolia dc boiss essential oil made by sonication and filtration methods |
| topic | <i>ducrosia anethifolia</i> essential oil gas chromatography coupled with mass spectrometer (gc-ms) nanoliposome |
| url | http://jmp.ir/article-1-2341-en.html |
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