Comparison of Gd-Bz-TTDA, Gd-EOB-DTPA, and Gd-BOPTA for dynamic MR imaging of the liver in rat models
To evaluate the competitive potential of a new lipophilic paramagnetic complex, Gd-Bz-TTDA [4-benzyl-3,6,10-tri (carboxymethyl)-3,6,10-triazado-decanedioic acid] compared with two other commercially available MR hepatobiliary contrast agents, gadobenate dimeglumine (Gd-BOPTA) and gadoxetic acid (Gd-...
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| Format: | Article |
| Language: | English |
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Wiley
2012-03-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X11002403 |
| _version_ | 1811214759186399232 |
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| author | Twei-Shiun Jaw Shih-Hsien Chen Yun-Ming Wang Jui-Sheng Hsu Yu-Ting Kuo Yen-Yu Chiu Kun-Bow Tsai Tsyh-Jyi Hsieh Gin-Chung Liu |
| author_facet | Twei-Shiun Jaw Shih-Hsien Chen Yun-Ming Wang Jui-Sheng Hsu Yu-Ting Kuo Yen-Yu Chiu Kun-Bow Tsai Tsyh-Jyi Hsieh Gin-Chung Liu |
| author_sort | Twei-Shiun Jaw |
| collection | DOAJ |
| description | To evaluate the competitive potential of a new lipophilic paramagnetic complex, Gd-Bz-TTDA [4-benzyl-3,6,10-tri (carboxymethyl)-3,6,10-triazado-decanedioic acid] compared with two other commercially available MR hepatobiliary contrast agents, gadobenate dimeglumine (Gd-BOPTA) and gadoxetic acid (Gd-EOB-DTPA), dynamic MR imaging studies were performed on normal and hepatocellular carcinoma (HCC) rat models using a 1.5-Tesla MR scanner. The results indicate that normal rats that were injected with 0.1 mmol/kg Gd-Bz-TTDA showed significantly more intense and persistent liver enhancement than those that were injected with the same dose of Gd-EOB-DTPA or Gd-BOPTA. All of these agents showed similar enhancement patterns in the implanted HCC. The liver-lesion contrast-to-noise ratios were higher and more persistent in rats that were injected with Gd-Bz-TTDA. These results indicate that Gd-Bz-TTDA is comparable with the commercially available hepatobiliary agents, Gd-EOB-DTPA and Gd-BOPTA, and can result in more intense and prolonged liver enhancement while still providing better liver-lesion discrimination. These results warrant further large-scale studies. |
| first_indexed | 2024-04-12T06:10:06Z |
| format | Article |
| id | doaj.art-fd7ff823ff824f9b97817afa819edac8 |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-04-12T06:10:06Z |
| publishDate | 2012-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-fd7ff823ff824f9b97817afa819edac82022-12-22T03:44:45ZengWileyKaohsiung Journal of Medical Sciences1607-551X2012-03-0128313013710.1016/j.kjms.2011.10.017Comparison of Gd-Bz-TTDA, Gd-EOB-DTPA, and Gd-BOPTA for dynamic MR imaging of the liver in rat modelsTwei-Shiun Jaw0Shih-Hsien Chen1Yun-Ming Wang2Jui-Sheng Hsu3Yu-Ting Kuo4Yen-Yu Chiu5Kun-Bow Tsai6Tsyh-Jyi Hsieh7Gin-Chung Liu8Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, TaiwanDepartment of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Pathology, School of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanTo evaluate the competitive potential of a new lipophilic paramagnetic complex, Gd-Bz-TTDA [4-benzyl-3,6,10-tri (carboxymethyl)-3,6,10-triazado-decanedioic acid] compared with two other commercially available MR hepatobiliary contrast agents, gadobenate dimeglumine (Gd-BOPTA) and gadoxetic acid (Gd-EOB-DTPA), dynamic MR imaging studies were performed on normal and hepatocellular carcinoma (HCC) rat models using a 1.5-Tesla MR scanner. The results indicate that normal rats that were injected with 0.1 mmol/kg Gd-Bz-TTDA showed significantly more intense and persistent liver enhancement than those that were injected with the same dose of Gd-EOB-DTPA or Gd-BOPTA. All of these agents showed similar enhancement patterns in the implanted HCC. The liver-lesion contrast-to-noise ratios were higher and more persistent in rats that were injected with Gd-Bz-TTDA. These results indicate that Gd-Bz-TTDA is comparable with the commercially available hepatobiliary agents, Gd-EOB-DTPA and Gd-BOPTA, and can result in more intense and prolonged liver enhancement while still providing better liver-lesion discrimination. These results warrant further large-scale studies.http://www.sciencedirect.com/science/article/pii/S1607551X11002403Magnetic resonance imagingContrast agentsHepatobiliary |
| spellingShingle | Twei-Shiun Jaw Shih-Hsien Chen Yun-Ming Wang Jui-Sheng Hsu Yu-Ting Kuo Yen-Yu Chiu Kun-Bow Tsai Tsyh-Jyi Hsieh Gin-Chung Liu Comparison of Gd-Bz-TTDA, Gd-EOB-DTPA, and Gd-BOPTA for dynamic MR imaging of the liver in rat models Kaohsiung Journal of Medical Sciences Magnetic resonance imaging Contrast agents Hepatobiliary |
| title | Comparison of Gd-Bz-TTDA, Gd-EOB-DTPA, and Gd-BOPTA for dynamic MR imaging of the liver in rat models |
| title_full | Comparison of Gd-Bz-TTDA, Gd-EOB-DTPA, and Gd-BOPTA for dynamic MR imaging of the liver in rat models |
| title_fullStr | Comparison of Gd-Bz-TTDA, Gd-EOB-DTPA, and Gd-BOPTA for dynamic MR imaging of the liver in rat models |
| title_full_unstemmed | Comparison of Gd-Bz-TTDA, Gd-EOB-DTPA, and Gd-BOPTA for dynamic MR imaging of the liver in rat models |
| title_short | Comparison of Gd-Bz-TTDA, Gd-EOB-DTPA, and Gd-BOPTA for dynamic MR imaging of the liver in rat models |
| title_sort | comparison of gd bz ttda gd eob dtpa and gd bopta for dynamic mr imaging of the liver in rat models |
| topic | Magnetic resonance imaging Contrast agents Hepatobiliary |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X11002403 |
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