Elastin biology and tissue engineering with adult cells
The inability of adult cells to produce well-organized, robust elastic fibers has long been a barrier to the successful engineering of certain tissues. In this review, we focus primarily on elastin with respect to tissue-engineered vascular substitutes. To understand elastin regulation during normal...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2013-04-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2012-0040 |
| _version_ | 1818718885828886528 |
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| author | Saitow Cassandra B. Wise Steven G. Weiss Anthony S. Castellot John J. Kaplan David L. |
| author_facet | Saitow Cassandra B. Wise Steven G. Weiss Anthony S. Castellot John J. Kaplan David L. |
| author_sort | Saitow Cassandra B. |
| collection | DOAJ |
| description | The inability of adult cells to produce well-organized, robust elastic fibers has long been a barrier to the successful engineering of certain tissues. In this review, we focus primarily on elastin with respect to tissue-engineered vascular substitutes. To understand elastin regulation during normal development, we describe the role of various elastic fiber accessory proteins. Biochemical pathways regulating expression of the elastin gene are addressed, with particular focus on tissue-engineering research using adult-derived cells. |
| first_indexed | 2024-12-17T19:58:10Z |
| format | Article |
| id | doaj.art-fd80c3ee85b04ba0965b3fdb193fe2da |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-17T19:58:10Z |
| publishDate | 2013-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-fd80c3ee85b04ba0965b3fdb193fe2da2022-12-21T21:34:33ZengDe GruyterBiomolecular Concepts1868-50211868-503X2013-04-014217318510.1515/bmc-2012-0040Elastin biology and tissue engineering with adult cellsSaitow Cassandra B.0Wise Steven G.Weiss Anthony S.1Castellot John J.2Kaplan David L.3Tufts University, Department of Biomedical Engineering, Medford, MA, 02155, USAMolecular Biosciences, University of Sydney, Sydney, New South Wales, AustraliaSackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, 02111, USATufts University, Department of Biomedical Engineering, Medford, MA, 02155, USAThe inability of adult cells to produce well-organized, robust elastic fibers has long been a barrier to the successful engineering of certain tissues. In this review, we focus primarily on elastin with respect to tissue-engineered vascular substitutes. To understand elastin regulation during normal development, we describe the role of various elastic fiber accessory proteins. Biochemical pathways regulating expression of the elastin gene are addressed, with particular focus on tissue-engineering research using adult-derived cells.https://doi.org/10.1515/bmc-2012-0040elastinheparinsmooth muscle cellvascular tissue engineering |
| spellingShingle | Saitow Cassandra B. Wise Steven G. Weiss Anthony S. Castellot John J. Kaplan David L. Elastin biology and tissue engineering with adult cells Biomolecular Concepts elastin heparin smooth muscle cell vascular tissue engineering |
| title | Elastin biology and tissue engineering with adult cells |
| title_full | Elastin biology and tissue engineering with adult cells |
| title_fullStr | Elastin biology and tissue engineering with adult cells |
| title_full_unstemmed | Elastin biology and tissue engineering with adult cells |
| title_short | Elastin biology and tissue engineering with adult cells |
| title_sort | elastin biology and tissue engineering with adult cells |
| topic | elastin heparin smooth muscle cell vascular tissue engineering |
| url | https://doi.org/10.1515/bmc-2012-0040 |
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