Tuberculosis treatment outcomes in children
The objective of the study: to assess tuberculosis treatment outcomes in children of 0-14 years old following up changes over the time Subjects and Methods: A retrospective cohort analysis of tuberculosis outcomes in 15,794 children of 0-14 years old was performed, those children were registered for...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2021-11-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1574 |
| _version_ | 1826563025514004480 |
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| author | V. A. Аksenova L. I. Rusakova S. A. Sterlikov |
| author_facet | V. A. Аksenova L. I. Rusakova S. A. Sterlikov |
| author_sort | V. A. Аksenova |
| collection | DOAJ |
| description | The objective of the study: to assess tuberculosis treatment outcomes in children of 0-14 years old following up changes over the time Subjects and Methods: A retrospective cohort analysis of tuberculosis outcomes in 15,794 children of 0-14 years old was performed, those children were registered for treatment from 2011 to 2018.Results. The percentage of children switched to MDR regimens increased from 1.3% to 12.0%. The rate of successful treatment of new TB cases in children varied from 93.2% to 96.6% in different years. In children registered for treatment in 2016-2018, 95.7% of new cases with negative or undocumented sputum smear microscopy, 87.8% with positive sputum smear microscopy, and only 83.3% of children with TB relapse were successfully treated. From 2015 to 2018, the percentage of children with treatment failures increased from 0.6% to 1.5%.Conclusion. Compared to other countries, Russia has a high rate of successful treatment in children with tuberculosis which may be due to their active detection. Nevertheless, there are certain defects in drug susceptibility testing of index cases. Treatment outcomes for children registered in 2020 are expected to be less favorable because of later detection due to the COVID-19 pandemic. The spread of HIV infection among children as well poses a threat of increased mortality in children ill with tuberculosis. To reduce the level of unfavorable outcomes, it is necessary to consider the treatment of children at the age of 0-14 years old ill with tuberculosis in federal centers. |
| first_indexed | 2024-03-12T04:49:29Z |
| format | Article |
| id | doaj.art-fd81413e44084d6fb1ff4cd6b2fc349e |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2025-03-14T09:57:24Z |
| publishDate | 2021-11-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-fd81413e44084d6fb1ff4cd6b2fc349e2025-03-02T11:22:34ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062021-11-01991071310.21292/2075-1230-2021-99-10-7-131569Tuberculosis treatment outcomes in childrenV. A. Аksenova0L. I. Rusakova1S. A. Sterlikov2National Medical Research Center of Phthisiopulmonology and Infectious DiseasesCentral Tuberculosis Research InstituteCentral Research Institute for Health Organization and InformaticsThe objective of the study: to assess tuberculosis treatment outcomes in children of 0-14 years old following up changes over the time Subjects and Methods: A retrospective cohort analysis of tuberculosis outcomes in 15,794 children of 0-14 years old was performed, those children were registered for treatment from 2011 to 2018.Results. The percentage of children switched to MDR regimens increased from 1.3% to 12.0%. The rate of successful treatment of new TB cases in children varied from 93.2% to 96.6% in different years. In children registered for treatment in 2016-2018, 95.7% of new cases with negative or undocumented sputum smear microscopy, 87.8% with positive sputum smear microscopy, and only 83.3% of children with TB relapse were successfully treated. From 2015 to 2018, the percentage of children with treatment failures increased from 0.6% to 1.5%.Conclusion. Compared to other countries, Russia has a high rate of successful treatment in children with tuberculosis which may be due to their active detection. Nevertheless, there are certain defects in drug susceptibility testing of index cases. Treatment outcomes for children registered in 2020 are expected to be less favorable because of later detection due to the COVID-19 pandemic. The spread of HIV infection among children as well poses a threat of increased mortality in children ill with tuberculosis. To reduce the level of unfavorable outcomes, it is necessary to consider the treatment of children at the age of 0-14 years old ill with tuberculosis in federal centers.https://www.tibl-journal.com/jour/article/view/1574tuberculosis in childrentuberculosis treatment outcomes in childrenmultiple drug resistant tuberculosis in children |
| spellingShingle | V. A. Аksenova L. I. Rusakova S. A. Sterlikov Tuberculosis treatment outcomes in children Туберкулез и болезни лёгких tuberculosis in children tuberculosis treatment outcomes in children multiple drug resistant tuberculosis in children |
| title | Tuberculosis treatment outcomes in children |
| title_full | Tuberculosis treatment outcomes in children |
| title_fullStr | Tuberculosis treatment outcomes in children |
| title_full_unstemmed | Tuberculosis treatment outcomes in children |
| title_short | Tuberculosis treatment outcomes in children |
| title_sort | tuberculosis treatment outcomes in children |
| topic | tuberculosis in children tuberculosis treatment outcomes in children multiple drug resistant tuberculosis in children |
| url | https://www.tibl-journal.com/jour/article/view/1574 |
| work_keys_str_mv | AT vaaksenova tuberculosistreatmentoutcomesinchildren AT lirusakova tuberculosistreatmentoutcomesinchildren AT sasterlikov tuberculosistreatmentoutcomesinchildren |