Direct Chemiluminescence Determination of Oxymorphone Using Potassium Permanganate and Polyphosphoric Acid
Abstract A simple and sensitive chemiluminescence (CL) method was developed for direct quantification of oxymorphone, a µ opioid agonist that is approximately 10 times more potent than morphine. In this method potassium permanganate in polyphosphoric acid was used as CL reagent. Using this method, o...
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| Format: | Article |
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Iranian Chemical Society
2017-06-01
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| Series: | Analytical and Bioanalytical Chemistry Research |
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| Online Access: | http://www.analchemres.org/article_44561_eecb1bdd6269a1efd19d464c66d94abd.pdf |
| _version_ | 1819010191993077760 |
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| author | Maryam Koohsarian Ali Mokhtari |
| author_facet | Maryam Koohsarian Ali Mokhtari |
| author_sort | Maryam Koohsarian |
| collection | DOAJ |
| description | Abstract A simple and sensitive chemiluminescence (CL) method was developed for direct quantification of oxymorphone, a µ opioid agonist that is approximately 10 times more potent than morphine. In this method potassium permanganate in polyphosphoric acid was used as CL reagent. Using this method, oxymorphone can be determined over the concentration ranges 13.5-337.8 ng mL-1 and 0.34-6.76 µg mL-1 with a sampling rate of 45 samples h−1. The limit of detection was 3.5 ng mL-1 (signal to noise =3) and the percent of relative standard deviations (in 9 replicate measurements) were 3.1% for 135.1 ng mL-1 and 3.6% for 1.4 µg mL-1 oxymorphone. The method is applied to human plasma and synthetic samples. The CL mechanism has been proposed using UV-Vis, fluorescence and CL spectra. In this study, detectability of oxymorphone in some other CL systems such as Ce(IV)-H2SO4, luminol-H2O2, Ru(phen)32+-Ce(IV) and permanganate-SO32- is investigated. CL intensities of twelve narcotics or related drugs were also investigated in the proposed CL system. |
| first_indexed | 2024-12-21T01:08:21Z |
| format | Article |
| id | doaj.art-fd84393045db4b67a21bcdb8a3a6b32b |
| institution | Directory Open Access Journal |
| issn | 2383-093X 2383-093X |
| language | English |
| last_indexed | 2024-12-21T01:08:21Z |
| publishDate | 2017-06-01 |
| publisher | Iranian Chemical Society |
| record_format | Article |
| series | Analytical and Bioanalytical Chemistry Research |
| spelling | doaj.art-fd84393045db4b67a21bcdb8a3a6b32b2022-12-21T19:20:59ZengIranian Chemical SocietyAnalytical and Bioanalytical Chemistry Research2383-093X2383-093X2017-06-014112713910.22036/abcr.2017.68970.112344561Direct Chemiluminescence Determination of Oxymorphone Using Potassium Permanganate and Polyphosphoric AcidMaryam Koohsarian0Ali Mokhtari1Department of Chemistry, Golestan University, Gorgan, IR IranDepartment of Chemistry, Golestan University, Gorgan, IR IranAbstract A simple and sensitive chemiluminescence (CL) method was developed for direct quantification of oxymorphone, a µ opioid agonist that is approximately 10 times more potent than morphine. In this method potassium permanganate in polyphosphoric acid was used as CL reagent. Using this method, oxymorphone can be determined over the concentration ranges 13.5-337.8 ng mL-1 and 0.34-6.76 µg mL-1 with a sampling rate of 45 samples h−1. The limit of detection was 3.5 ng mL-1 (signal to noise =3) and the percent of relative standard deviations (in 9 replicate measurements) were 3.1% for 135.1 ng mL-1 and 3.6% for 1.4 µg mL-1 oxymorphone. The method is applied to human plasma and synthetic samples. The CL mechanism has been proposed using UV-Vis, fluorescence and CL spectra. In this study, detectability of oxymorphone in some other CL systems such as Ce(IV)-H2SO4, luminol-H2O2, Ru(phen)32+-Ce(IV) and permanganate-SO32- is investigated. CL intensities of twelve narcotics or related drugs were also investigated in the proposed CL system.http://www.analchemres.org/article_44561_eecb1bdd6269a1efd19d464c66d94abd.pdfChemiluminescenceOxymorphonePotassium permanganatePolyphosphoric acid |
| spellingShingle | Maryam Koohsarian Ali Mokhtari Direct Chemiluminescence Determination of Oxymorphone Using Potassium Permanganate and Polyphosphoric Acid Analytical and Bioanalytical Chemistry Research Chemiluminescence Oxymorphone Potassium permanganate Polyphosphoric acid |
| title | Direct Chemiluminescence Determination of Oxymorphone Using Potassium Permanganate and Polyphosphoric Acid |
| title_full | Direct Chemiluminescence Determination of Oxymorphone Using Potassium Permanganate and Polyphosphoric Acid |
| title_fullStr | Direct Chemiluminescence Determination of Oxymorphone Using Potassium Permanganate and Polyphosphoric Acid |
| title_full_unstemmed | Direct Chemiluminescence Determination of Oxymorphone Using Potassium Permanganate and Polyphosphoric Acid |
| title_short | Direct Chemiluminescence Determination of Oxymorphone Using Potassium Permanganate and Polyphosphoric Acid |
| title_sort | direct chemiluminescence determination of oxymorphone using potassium permanganate and polyphosphoric acid |
| topic | Chemiluminescence Oxymorphone Potassium permanganate Polyphosphoric acid |
| url | http://www.analchemres.org/article_44561_eecb1bdd6269a1efd19d464c66d94abd.pdf |
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