Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson’s disease with PARK2 mutation
PARK2 is the most common autosomal recessive form of Parkinson’s disease and is caused by mutations in parkin that result in early-onset loss of dopaminergic neurons in the substantia nigra. In this study, we established an induced pluripotent stem cell (iPSC) line from a patient harboring a homozyg...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506124000217 |
| _version_ | 1827360988032139264 |
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| author | Kei-ichi Ishikawa Ayami Okuzumi Hiroyo Yoshino Nobutaka Hattori Wado Akamatsu |
| author_facet | Kei-ichi Ishikawa Ayami Okuzumi Hiroyo Yoshino Nobutaka Hattori Wado Akamatsu |
| author_sort | Kei-ichi Ishikawa |
| collection | DOAJ |
| description | PARK2 is the most common autosomal recessive form of Parkinson’s disease and is caused by mutations in parkin that result in early-onset loss of dopaminergic neurons in the substantia nigra. In this study, we established an induced pluripotent stem cell (iPSC) line from a patient harboring a homozygous exon 3 deletion in PARK2. The established iPSCs showed pluripotency, the capacity to differentiate into the three germ layers, and normal karyotypes. |
| first_indexed | 2024-03-08T06:57:27Z |
| format | Article |
| id | doaj.art-fd84481b5a3a4c56968962eb29a05392 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-03-08T06:57:27Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-fd84481b5a3a4c56968962eb29a053922024-02-03T06:35:27ZengElsevierStem Cell Research1873-50612024-04-0176103323Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson’s disease with PARK2 mutationKei-ichi Ishikawa0Ayami Okuzumi1Hiroyo Yoshino2Nobutaka Hattori3Wado Akamatsu4Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Department of Research and Development for Organoids, Juntendo University School of Medicine, Tokyo, Japan; Corresponding author.Department of Neurology, Juntendo University School of Medicine, Tokyo, JapanResearch Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, JapanCenter for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Department of Research and Development for Organoids, Juntendo University School of Medicine, Tokyo, Japan; Neurodegenerative Disorders Collaborative Laboratory, RIKEN Center for Brain Science, Saitama, JapanCenter for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, JapanPARK2 is the most common autosomal recessive form of Parkinson’s disease and is caused by mutations in parkin that result in early-onset loss of dopaminergic neurons in the substantia nigra. In this study, we established an induced pluripotent stem cell (iPSC) line from a patient harboring a homozygous exon 3 deletion in PARK2. The established iPSCs showed pluripotency, the capacity to differentiate into the three germ layers, and normal karyotypes.http://www.sciencedirect.com/science/article/pii/S1873506124000217 |
| spellingShingle | Kei-ichi Ishikawa Ayami Okuzumi Hiroyo Yoshino Nobutaka Hattori Wado Akamatsu Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson’s disease with PARK2 mutation Stem Cell Research |
| title | Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson’s disease with PARK2 mutation |
| title_full | Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson’s disease with PARK2 mutation |
| title_fullStr | Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson’s disease with PARK2 mutation |
| title_full_unstemmed | Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson’s disease with PARK2 mutation |
| title_short | Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson’s disease with PARK2 mutation |
| title_sort | generation of hipscs jucgrmi003 a from a patient with parkinson s disease with park2 mutation |
| url | http://www.sciencedirect.com/science/article/pii/S1873506124000217 |
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