Imatinib induces diastolic dysfunction and ventricular early-repolarization delay in the halothane-anesthetized dogs: Class effects of tyrosine kinase inhibitors

Imatinib induces diastolic dysfunction and ventricular early-repolarization delay in the halothane-anesthetized dogs: Class effects of tyrosine kinase inhibitors

Imatinib has been reported to induce heart failure and/or QTc prolongation. To better understand their underlying mechanisms, we assessed its effects on cardiohemodynamic, electrocardiographic and echocardiographic variables along with biomarkers of myocardial damage. Imatinib mesylate in doses of 1...

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Bibliographic Details
Main Authors: Koki Chiba, Ryuichi Kambayashi, Mayu Onozato, Ai Goto, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Koichiro Tanaka, Yasunari Kanda, Takeshi Fukushima, Atsushi Sugiyama
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Journal of Pharmacological Sciences
Subjects:
Imatinib
Diastolic dysfunction
Tyrosine kinase inhibitor
Safety pharmacology
QTc
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861322000603

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