BioSAXS Measurements Reveal That Two Antimicrobial Peptides Induce Similar Molecular Changes in Gram-Negative and Gram-Positive Bacteria

BioSAXS Measurements Reveal That Two Antimicrobial Peptides Induce Similar Molecular Changes in Gram-Negative and Gram-Positive Bacteria

Two highly active short broad-spectrum AMPs (14D and 69D) with unknown mode of action have been investigated in regards to their effect against the Gram-negative bacteria Escherichia coli and the Gram-positive bacteria methicillin-resistant Staphylococcus aureus (MRSA). Minimal inhibitory concentrat...

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Bibliographic Details
Main Authors: Andreas von Gundlach, Martin P. Ashby, Jurnorain Gani, Paula Matilde Lopez-Perez, Alan Roy Cookson, Sharon Ann Huws, Christoph Rumancev, Vasil M. Garamus, Ralf Mikut, Axel Rosenhahn, Kai Hilpert
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
antimicrobial peptide
mode of action
SAXS
MRSA
electron microscopy
E. coli
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01127/full

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