Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2
(1) Background: Cognitive decline (CD), considered a precursory state of dementia, is frequently encountered in patients with diabetes mellitus type 2 (DM-2) and might even have a higher prevalence in those with associated atrial fibrillation (AF). In this study, we aimed to research if the associat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/3/672 |
| _version_ | 1797241973131706368 |
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| author | Marius Militaru Daniel Florin Lighezan Cristina Tudoran Anda Gabriela Militaru |
| author_facet | Marius Militaru Daniel Florin Lighezan Cristina Tudoran Anda Gabriela Militaru |
| author_sort | Marius Militaru |
| collection | DOAJ |
| description | (1) Background: Cognitive decline (CD), considered a precursory state of dementia, is frequently encountered in patients with diabetes mellitus type 2 (DM-2) and might even have a higher prevalence in those with associated atrial fibrillation (AF). In this study, we aimed to research if the association of DM-2 and AF favors a precocious onset of CD. (2) Methods: This study was conducted on 160 patients, featuring 50 with DM-2, 54 with DM-2 and AF, and 56 subjects without DM-2 and AF, all evaluated clinically and with five neuropsychiatric scales. (3) Results: The Mini-Mental-State-Examination (MMSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living Score (ADL), Instrumental Activities of Daily Living Score (IADL), and Geriatric Depression Scale (GDS-15) were significantly altered in patients with DM-2 and AF in comparison to patients without these diseases. The logistic regression model indicated that, in patients with DM-2 and AF, an increase of one year in age is associated with a 7.3% augmentation of the risk of a precocious onset of CD (MMSE < 27). (4) Conclusions: CD is more frequent in patients with DM-2, especially when associated with AF, versus those without DM-2 and AF. Our findings suggest that an older age and associated dyslipidemia represent risk factors for CD in patients with DM-2. |
| first_indexed | 2024-04-24T18:31:50Z |
| format | Article |
| id | doaj.art-fd8928d71fb640769c21c9a0940b9832 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-04-24T18:31:50Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-fd8928d71fb640769c21c9a0940b98322024-03-27T13:23:05ZengMDPI AGBiomedicines2227-90592024-03-0112367210.3390/biomedicines12030672Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2Marius Militaru0Daniel Florin Lighezan1Cristina Tudoran2Anda Gabriela Militaru3Department VIII, Neuroscience, Discipline of Neurology II, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaMunicipal Emergency Hospital Timisoara, Gheorghe Dima Street Nr. 5, 300254 Timisoara, RomaniaDepartment VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaMunicipal Emergency Hospital Timisoara, Gheorghe Dima Street Nr. 5, 300254 Timisoara, Romania(1) Background: Cognitive decline (CD), considered a precursory state of dementia, is frequently encountered in patients with diabetes mellitus type 2 (DM-2) and might even have a higher prevalence in those with associated atrial fibrillation (AF). In this study, we aimed to research if the association of DM-2 and AF favors a precocious onset of CD. (2) Methods: This study was conducted on 160 patients, featuring 50 with DM-2, 54 with DM-2 and AF, and 56 subjects without DM-2 and AF, all evaluated clinically and with five neuropsychiatric scales. (3) Results: The Mini-Mental-State-Examination (MMSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living Score (ADL), Instrumental Activities of Daily Living Score (IADL), and Geriatric Depression Scale (GDS-15) were significantly altered in patients with DM-2 and AF in comparison to patients without these diseases. The logistic regression model indicated that, in patients with DM-2 and AF, an increase of one year in age is associated with a 7.3% augmentation of the risk of a precocious onset of CD (MMSE < 27). (4) Conclusions: CD is more frequent in patients with DM-2, especially when associated with AF, versus those without DM-2 and AF. Our findings suggest that an older age and associated dyslipidemia represent risk factors for CD in patients with DM-2.https://www.mdpi.com/2227-9059/12/3/672diabetes mellitusatrial fibrillationcognitive declinedementiasubclinical atherosclerosismemory tests |
| spellingShingle | Marius Militaru Daniel Florin Lighezan Cristina Tudoran Anda Gabriela Militaru Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2 Biomedicines diabetes mellitus atrial fibrillation cognitive decline dementia subclinical atherosclerosis memory tests |
| title | Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2 |
| title_full | Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2 |
| title_fullStr | Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2 |
| title_full_unstemmed | Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2 |
| title_short | Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2 |
| title_sort | connections between cognitive impairment and atrial fibrillation in patients with diabetes mellitus type 2 |
| topic | diabetes mellitus atrial fibrillation cognitive decline dementia subclinical atherosclerosis memory tests |
| url | https://www.mdpi.com/2227-9059/12/3/672 |
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