Modulating the Ubiquitin–Proteasome System: A Therapeutic Strategy for Autoimmune Diseases

Modulating the Ubiquitin–Proteasome System: A Therapeutic Strategy for Autoimmune Diseases

Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease associated with the central nervous system (CNS). Autoimmunity is caused by an abnormal immune response to self-antigens, which results in chronic inflammation and tissue death. Ubiquitination is a post-translational modification in...

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Bibliographic Details
Main Authors: Dhananjay Yadav, Ji Yeon Lee, Nidhi Puranik, Pallavi S. Chauhan, Vishal Chavda, Jun-O. Jin, Peter C. W. Lee
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
autoimmune disease
central nervous system
multiple sclerosis
UPS
therapeutic target
26S proteasome
Online Access:https://www.mdpi.com/2073-4409/11/7/1093

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