Effects of novel quinoid thiosulfonate derivative on ADP-induced platelet aggregation
Recently, in a large scale screening test, we have found that S-((1,4-dimethoxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)4-aminobenzenesulfonothioate, a chemically synthesized thiosulfonate derivative of quinone, possessed an antiplatelet activity. To elucidate the mechanism of its antiplatelet...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taras Shevchenko National University of Kyiv
2016-07-01
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| Series: | Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ |
| Subjects: | |
| Online Access: | http://biovestnik.com/index.php/biology/article/view/26 |
| _version_ | 1797710874223312896 |
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| author | T. Halenova I. Nikolaieva O. Savchuk K. Bolibrukh S. Polovkovych V. Novikov |
| author_facet | T. Halenova I. Nikolaieva O. Savchuk K. Bolibrukh S. Polovkovych V. Novikov |
| author_sort | T. Halenova |
| collection | DOAJ |
| description | Recently, in a large scale screening test, we have found that S-((1,4-dimethoxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)4-aminobenzenesulfonothioate, a chemically synthesized thiosulfonate derivative of quinone, possessed an antiplatelet activity. To elucidate the mechanism of its antiplatelet action, a series of experiments were performed. The compound was found to inhibit the ADP-induced platelet aggregation. The inhibitory effect was dose-dependent on concentration and preincubation time. The derivative also disaggregated the preformed platelet aggregates induced by ADP. |
| first_indexed | 2024-03-12T06:58:37Z |
| format | Article |
| id | doaj.art-fd8a339648f84d8dbc78119b94786af7 |
| institution | Directory Open Access Journal |
| issn | 1728-2748 2308-8036 |
| language | English |
| last_indexed | 2024-03-12T06:58:37Z |
| publishDate | 2016-07-01 |
| publisher | Taras Shevchenko National University of Kyiv |
| record_format | Article |
| series | Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ |
| spelling | doaj.art-fd8a339648f84d8dbc78119b94786af72023-09-02T23:56:22ZengTaras Shevchenko National University of KyivVìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ1728-27482308-80362016-07-01683364010.17721/1728_2748.2014.68.36-4026Effects of novel quinoid thiosulfonate derivative on ADP-induced platelet aggregationT. Halenova0I. Nikolaieva1O. Savchuk2K. Bolibrukh3S. Polovkovych4V. Novikov5Taras Shevchenko National University of Kyiv, KyivTaras Shevchenko National University of Kyiv, KyivTaras Shevchenko National University of Kyiv, KyivLviv Polytechnic National University, LvivLviv Polytechnic National University, LvivLviv Polytechnic National University, LvivRecently, in a large scale screening test, we have found that S-((1,4-dimethoxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)4-aminobenzenesulfonothioate, a chemically synthesized thiosulfonate derivative of quinone, possessed an antiplatelet activity. To elucidate the mechanism of its antiplatelet action, a series of experiments were performed. The compound was found to inhibit the ADP-induced platelet aggregation. The inhibitory effect was dose-dependent on concentration and preincubation time. The derivative also disaggregated the preformed platelet aggregates induced by ADP.http://biovestnik.com/index.php/biology/article/view/26platelet rich plasma, quinoid thiosulfonate derivative, ADP-induced platelet aggregation, antiplatelet agents |
| spellingShingle | T. Halenova I. Nikolaieva O. Savchuk K. Bolibrukh S. Polovkovych V. Novikov Effects of novel quinoid thiosulfonate derivative on ADP-induced platelet aggregation Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ platelet rich plasma, quinoid thiosulfonate derivative, ADP-induced platelet aggregation, antiplatelet agents |
| title | Effects of novel quinoid thiosulfonate derivative on ADP-induced platelet aggregation |
| title_full | Effects of novel quinoid thiosulfonate derivative on ADP-induced platelet aggregation |
| title_fullStr | Effects of novel quinoid thiosulfonate derivative on ADP-induced platelet aggregation |
| title_full_unstemmed | Effects of novel quinoid thiosulfonate derivative on ADP-induced platelet aggregation |
| title_short | Effects of novel quinoid thiosulfonate derivative on ADP-induced platelet aggregation |
| title_sort | effects of novel quinoid thiosulfonate derivative on adp induced platelet aggregation |
| topic | platelet rich plasma, quinoid thiosulfonate derivative, ADP-induced platelet aggregation, antiplatelet agents |
| url | http://biovestnik.com/index.php/biology/article/view/26 |
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