Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis
Acute Myeloid Leukemia is one of the most aggressive blood cancers with a high frequency of relapse. While standard chemotherapy is able to target rapidly proliferating immature blasts, it fails to eradicate slowly proliferating Leukemic Stem Cells. Therefore, new therapeutic strategies that efficie...
Main Authors: | Elisa Donato, Andreas Trumpp |
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Format: | Article |
Language: | English |
Published: |
Springer Nature
2022-07-01
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Series: | EMBO Molecular Medicine |
Online Access: | https://doi.org/10.15252/emmm.202216171 |
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