The synthesis of water-soluble CDM-AM copolymer by irradiation and its solubilization effect on hydrophobic drugs
The β-cyclodextrin-acrylamide (CDM-AM) copolymer was prepared from acrylamide and β-CD maleate (CDM) using 60Co γ-ray irradiation method. The optimized preparation conditions for the CDM-AM copolymer are as follows: CDM:AM mass ratio of 1:1; irradiation dose of 4 kGy; and using 20 mL of DMF water so...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-01-01
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| Series: | Designed Monomers and Polymers |
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| Online Access: | http://dx.doi.org/10.1080/15685551.2018.1480681 |
| _version_ | 1818260817299111936 |
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| author | Yong-Fu Li Hong-Tao Tang Si-Jing Zhou |
| author_facet | Yong-Fu Li Hong-Tao Tang Si-Jing Zhou |
| author_sort | Yong-Fu Li |
| collection | DOAJ |
| description | The β-cyclodextrin-acrylamide (CDM-AM) copolymer was prepared from acrylamide and β-CD maleate (CDM) using 60Co γ-ray irradiation method. The optimized preparation conditions for the CDM-AM copolymer are as follows: CDM:AM mass ratio of 1:1; irradiation dose of 4 kGy; and using 20 mL of DMF water solution. The yield rate of CDM-AM was 75% in grams using these synthetic conditions. The effects of the CDM-AM copolymer on the solubility and fungicidal activity of natamycin (NM) and carbendazim (MBC) were investigated. The stability constant of NM·CDM-AM and MBC·CDM-AM complexes at 303 K were of 13,446.06 M−1 and 2595.3 M−1, respectively. The complexes were characterized using phase solubility diagrams, NMR spectra and FT-IR spectra. The analysis of the biological activities of these two complexes indicated that they possessed enhancing fungicidal activities compared to NM and MBC alone. |
| first_indexed | 2024-12-12T18:37:21Z |
| format | Article |
| id | doaj.art-fd8c0d5b0f6243958ed71d0bd97f0845 |
| institution | Directory Open Access Journal |
| issn | 1568-5551 |
| language | English |
| last_indexed | 2024-12-12T18:37:21Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Designed Monomers and Polymers |
| spelling | doaj.art-fd8c0d5b0f6243958ed71d0bd97f08452022-12-22T00:15:46ZengTaylor & Francis GroupDesigned Monomers and Polymers1568-55512018-01-0121110511510.1080/15685551.2018.14806811480681The synthesis of water-soluble CDM-AM copolymer by irradiation and its solubilization effect on hydrophobic drugsYong-Fu Li0Hong-Tao Tang1Si-Jing Zhou2Guizhou Academy of Agricultural SciencesNational Center for Child Nutriment Quality Supervision and Testing, China National Children’s CenterBeijing Radiation CenterThe β-cyclodextrin-acrylamide (CDM-AM) copolymer was prepared from acrylamide and β-CD maleate (CDM) using 60Co γ-ray irradiation method. The optimized preparation conditions for the CDM-AM copolymer are as follows: CDM:AM mass ratio of 1:1; irradiation dose of 4 kGy; and using 20 mL of DMF water solution. The yield rate of CDM-AM was 75% in grams using these synthetic conditions. The effects of the CDM-AM copolymer on the solubility and fungicidal activity of natamycin (NM) and carbendazim (MBC) were investigated. The stability constant of NM·CDM-AM and MBC·CDM-AM complexes at 303 K were of 13,446.06 M−1 and 2595.3 M−1, respectively. The complexes were characterized using phase solubility diagrams, NMR spectra and FT-IR spectra. The analysis of the biological activities of these two complexes indicated that they possessed enhancing fungicidal activities compared to NM and MBC alone.http://dx.doi.org/10.1080/15685551.2018.1480681IrradiationSolubilityβ-cyclodextrinCopolymerFungicidal activity |
| spellingShingle | Yong-Fu Li Hong-Tao Tang Si-Jing Zhou The synthesis of water-soluble CDM-AM copolymer by irradiation and its solubilization effect on hydrophobic drugs Designed Monomers and Polymers Irradiation Solubility β-cyclodextrin Copolymer Fungicidal activity |
| title | The synthesis of water-soluble CDM-AM copolymer by irradiation and its solubilization effect on hydrophobic drugs |
| title_full | The synthesis of water-soluble CDM-AM copolymer by irradiation and its solubilization effect on hydrophobic drugs |
| title_fullStr | The synthesis of water-soluble CDM-AM copolymer by irradiation and its solubilization effect on hydrophobic drugs |
| title_full_unstemmed | The synthesis of water-soluble CDM-AM copolymer by irradiation and its solubilization effect on hydrophobic drugs |
| title_short | The synthesis of water-soluble CDM-AM copolymer by irradiation and its solubilization effect on hydrophobic drugs |
| title_sort | synthesis of water soluble cdm am copolymer by irradiation and its solubilization effect on hydrophobic drugs |
| topic | Irradiation Solubility β-cyclodextrin Copolymer Fungicidal activity |
| url | http://dx.doi.org/10.1080/15685551.2018.1480681 |
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