Role of autophagy in lung diseases and ageing
The lungs face ongoing chemical, mechanical, biological, immunological and xenobiotic stresses over a lifetime. Advancing age progressively impairs lung function. Autophagy is a “housekeeping” survival strategy involved in numerous physiological and pathological processes in all eukaryotic cells. Au...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2022-12-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/31/166/220134.full |
| _version_ | 1797961088783876096 |
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| author | Yan Zhang Jin Zhang Zhiling Fu |
| author_facet | Yan Zhang Jin Zhang Zhiling Fu |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | The lungs face ongoing chemical, mechanical, biological, immunological and xenobiotic stresses over a lifetime. Advancing age progressively impairs lung function. Autophagy is a “housekeeping” survival strategy involved in numerous physiological and pathological processes in all eukaryotic cells. Autophagic activity decreases with age in several species, whereas its basic activity extends throughout the lifespan of most animals. Dysregulation of autophagy has been proven to be closely related to the pathogenesis of several ageing-related pulmonary diseases. This review summarises the role of autophagy in the pathogenesis of pulmonary diseases associated with or occurring in the context of ageing, including acute lung injury, chronic obstructive pulmonary disease, asthma and pulmonary fibrosis, and describes its potential as a therapeutic target. |
| first_indexed | 2024-04-11T00:53:55Z |
| format | Article |
| id | doaj.art-fd8e46f486e346f18fadb4d23bc62b56 |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-04-11T00:53:55Z |
| publishDate | 2022-12-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-fd8e46f486e346f18fadb4d23bc62b562023-01-05T07:48:22ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172022-12-013116610.1183/16000617.0134-20220134-2022Role of autophagy in lung diseases and ageingYan Zhang0Jin Zhang1Zhiling Fu2 Shengjing Hospital of China Medical University, Shenyang, China Shengjing Hospital of China Medical University, Shenyang, China Shengjing Hospital of China Medical University, Shenyang, China The lungs face ongoing chemical, mechanical, biological, immunological and xenobiotic stresses over a lifetime. Advancing age progressively impairs lung function. Autophagy is a “housekeeping” survival strategy involved in numerous physiological and pathological processes in all eukaryotic cells. Autophagic activity decreases with age in several species, whereas its basic activity extends throughout the lifespan of most animals. Dysregulation of autophagy has been proven to be closely related to the pathogenesis of several ageing-related pulmonary diseases. This review summarises the role of autophagy in the pathogenesis of pulmonary diseases associated with or occurring in the context of ageing, including acute lung injury, chronic obstructive pulmonary disease, asthma and pulmonary fibrosis, and describes its potential as a therapeutic target.http://err.ersjournals.com/content/31/166/220134.full |
| spellingShingle | Yan Zhang Jin Zhang Zhiling Fu Role of autophagy in lung diseases and ageing European Respiratory Review |
| title | Role of autophagy in lung diseases and ageing |
| title_full | Role of autophagy in lung diseases and ageing |
| title_fullStr | Role of autophagy in lung diseases and ageing |
| title_full_unstemmed | Role of autophagy in lung diseases and ageing |
| title_short | Role of autophagy in lung diseases and ageing |
| title_sort | role of autophagy in lung diseases and ageing |
| url | http://err.ersjournals.com/content/31/166/220134.full |
| work_keys_str_mv | AT yanzhang roleofautophagyinlungdiseasesandageing AT jinzhang roleofautophagyinlungdiseasesandageing AT zhilingfu roleofautophagyinlungdiseasesandageing |