Cell-based Treatments of Femoral Head Osteonecrosis: A Literature Review
The preferred desire of orthopedic surgeons is to preserve the femoral head in the early stages of femoral head osteonecrosis; however, hip arthroplasty is needed in most cases. The outcomes of traditional surgical treatments alone are not favorable. Thus, femoral head osteonecrosis frequently follo...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2018-06-01
|
| Series: | Reviews in Clinical Medicine |
| Subjects: | |
| Online Access: | https://rcm.mums.ac.ir/article_11124_d77f49e98ca13de95afd4f4ea2807fa6.pdf |
| _version_ | 1797976113679433728 |
|---|---|
| author | Ali Parsa Mohammad Hallaj Moghaddam Farshid Bagheri Mohammad Hassani |
| author_facet | Ali Parsa Mohammad Hallaj Moghaddam Farshid Bagheri Mohammad Hassani |
| author_sort | Ali Parsa |
| collection | DOAJ |
| description | The preferred desire of orthopedic surgeons is to preserve the femoral head in the early stages of femoral head osteonecrosis; however, hip arthroplasty is needed in most cases. The outcomes of traditional surgical treatments alone are not favorable. Thus, femoral head osteonecrosis frequently follows an unpredictable course resulting in significant hip arthritis. Through the years, it has been identified that decreased proliferation capacity and content of bone marrow stem cells (BMSCs) in the femoral head region play a key role in the pathogenesis of osteonecrosis of femoral head (ONFH). In the past two decades, researchers have focused on cell-based therapies for ONFH treatment. The regenerative potential of damaged cartilage and bone tissue with stem cells has become a new treatment approach in the field of orthopedics. Ongoing basic science and clinical studies are progressing toward efficient standard treatment options for this extremely challenging condition. In this article, we reviewed the recently developed methods of cell therapy for these types of musculoskeletal conditions. |
| first_indexed | 2024-04-11T04:46:12Z |
| format | Article |
| id | doaj.art-fd90a90770794c2192707e747a7b7124 |
| institution | Directory Open Access Journal |
| issn | 2345-6256 2345-6892 |
| language | English |
| last_indexed | 2024-04-11T04:46:12Z |
| publishDate | 2018-06-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Reviews in Clinical Medicine |
| spelling | doaj.art-fd90a90770794c2192707e747a7b71242022-12-27T13:07:08ZengMashhad University of Medical SciencesReviews in Clinical Medicine2345-62562345-68922018-06-0152545810.22038/rcm.2018.24046.120311124Cell-based Treatments of Femoral Head Osteonecrosis: A Literature ReviewAli Parsa0Mohammad Hallaj Moghaddam1Farshid Bagheri2Mohammad Hassani3Rothman Institute at Thomas Jefferson University, Philadelphia, USA.Orthopedic Research Center, Department of Orthopedic Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.Orthopedic Research Center, Department of Orthopedic Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.Orthopedic Research Center, Department of Orthopedic Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.The preferred desire of orthopedic surgeons is to preserve the femoral head in the early stages of femoral head osteonecrosis; however, hip arthroplasty is needed in most cases. The outcomes of traditional surgical treatments alone are not favorable. Thus, femoral head osteonecrosis frequently follows an unpredictable course resulting in significant hip arthritis. Through the years, it has been identified that decreased proliferation capacity and content of bone marrow stem cells (BMSCs) in the femoral head region play a key role in the pathogenesis of osteonecrosis of femoral head (ONFH). In the past two decades, researchers have focused on cell-based therapies for ONFH treatment. The regenerative potential of damaged cartilage and bone tissue with stem cells has become a new treatment approach in the field of orthopedics. Ongoing basic science and clinical studies are progressing toward efficient standard treatment options for this extremely challenging condition. In this article, we reviewed the recently developed methods of cell therapy for these types of musculoskeletal conditions.https://rcm.mums.ac.ir/article_11124_d77f49e98ca13de95afd4f4ea2807fa6.pdfcell therapyfemoral headosteonecrosisstem cell |
| spellingShingle | Ali Parsa Mohammad Hallaj Moghaddam Farshid Bagheri Mohammad Hassani Cell-based Treatments of Femoral Head Osteonecrosis: A Literature Review Reviews in Clinical Medicine cell therapy femoral head osteonecrosis stem cell |
| title | Cell-based Treatments of Femoral Head Osteonecrosis: A Literature Review |
| title_full | Cell-based Treatments of Femoral Head Osteonecrosis: A Literature Review |
| title_fullStr | Cell-based Treatments of Femoral Head Osteonecrosis: A Literature Review |
| title_full_unstemmed | Cell-based Treatments of Femoral Head Osteonecrosis: A Literature Review |
| title_short | Cell-based Treatments of Femoral Head Osteonecrosis: A Literature Review |
| title_sort | cell based treatments of femoral head osteonecrosis a literature review |
| topic | cell therapy femoral head osteonecrosis stem cell |
| url | https://rcm.mums.ac.ir/article_11124_d77f49e98ca13de95afd4f4ea2807fa6.pdf |
| work_keys_str_mv | AT aliparsa cellbasedtreatmentsoffemoralheadosteonecrosisaliteraturereview AT mohammadhallajmoghaddam cellbasedtreatmentsoffemoralheadosteonecrosisaliteraturereview AT farshidbagheri cellbasedtreatmentsoffemoralheadosteonecrosisaliteraturereview AT mohammadhassani cellbasedtreatmentsoffemoralheadosteonecrosisaliteraturereview |