The Influence of Differently Shaped Gold Nanoparticles Functionalized with NIPAM-Based Hydrogels on the Release of Cytochrome C
Here, we report the synthesis and functionalization of five different shapes of Au nanoparticles (NPs), namely nanorods, tetrahexahedral, bipyramids, nanomakura, and spheres with PEG and poly (N-isopropylacrylamide)-acrylic acid (pNIPAm-AAc) hydrogels. The anisotropic NPs are synthesized using seed-...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-11-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/3/4/42 |
| _version_ | 1811236516765106176 |
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| author | Sulalit Bandyopadhyay Anuvansh Sharma Wilhelm Robert Glomm |
| author_facet | Sulalit Bandyopadhyay Anuvansh Sharma Wilhelm Robert Glomm |
| author_sort | Sulalit Bandyopadhyay |
| collection | DOAJ |
| description | Here, we report the synthesis and functionalization of five different shapes of Au nanoparticles (NPs), namely nanorods, tetrahexahedral, bipyramids, nanomakura, and spheres with PEG and poly (N-isopropylacrylamide)-acrylic acid (pNIPAm-AAc) hydrogels. The anisotropic NPs are synthesized using seed-mediated growth in the presence of silver. The NPs have been characterized using Dynamic Light Scattering (DLS), zeta potential measurements, UV-Visible spectrophotometry (UV-Vis), and Scanning Transmission Electron Microscopy (S(T)EM). Cyt C was loaded into the PEG-hydrogel-coated AuNPs using a modified breathing-in method. Loading efficiencies (up to 80%), dependent on particle geometry, concentration, and hydrogel content, were obtained. Release experiments conducted at high temperature (40 °C) and acidic pH (3) showed higher release for larger sizes of PEG-hydrogel-coated AuNPs, with temporal transition from spherical to thin film release geometry. AuNP shape, size, number density, and hydrogel content are found to influence the loading as well as release kinetics of Cyt C from these systems. |
| first_indexed | 2024-04-12T12:09:44Z |
| format | Article |
| id | doaj.art-fd912c09b3fb48f1ab2b1e9a758b5030 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-04-12T12:09:44Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-fd912c09b3fb48f1ab2b1e9a758b50302022-12-22T03:33:36ZengMDPI AGGels2310-28612017-11-01344210.3390/gels3040042gels3040042The Influence of Differently Shaped Gold Nanoparticles Functionalized with NIPAM-Based Hydrogels on the Release of Cytochrome CSulalit Bandyopadhyay0Anuvansh Sharma1Wilhelm Robert Glomm2Ugelstad Laboratory, Department of Chemical Engineering, Norwegian University of Science and technology (NTNU), N-7491 Trondheim, NorwayUgelstad Laboratory, Department of Chemical Engineering, Norwegian University of Science and technology (NTNU), N-7491 Trondheim, NorwayUgelstad Laboratory, Department of Chemical Engineering, Norwegian University of Science and technology (NTNU), N-7491 Trondheim, NorwayHere, we report the synthesis and functionalization of five different shapes of Au nanoparticles (NPs), namely nanorods, tetrahexahedral, bipyramids, nanomakura, and spheres with PEG and poly (N-isopropylacrylamide)-acrylic acid (pNIPAm-AAc) hydrogels. The anisotropic NPs are synthesized using seed-mediated growth in the presence of silver. The NPs have been characterized using Dynamic Light Scattering (DLS), zeta potential measurements, UV-Visible spectrophotometry (UV-Vis), and Scanning Transmission Electron Microscopy (S(T)EM). Cyt C was loaded into the PEG-hydrogel-coated AuNPs using a modified breathing-in method. Loading efficiencies (up to 80%), dependent on particle geometry, concentration, and hydrogel content, were obtained. Release experiments conducted at high temperature (40 °C) and acidic pH (3) showed higher release for larger sizes of PEG-hydrogel-coated AuNPs, with temporal transition from spherical to thin film release geometry. AuNP shape, size, number density, and hydrogel content are found to influence the loading as well as release kinetics of Cyt C from these systems.https://www.mdpi.com/2310-2861/3/4/42anisotropygoldcytochrome CNIPAmnanostructuresPEG |
| spellingShingle | Sulalit Bandyopadhyay Anuvansh Sharma Wilhelm Robert Glomm The Influence of Differently Shaped Gold Nanoparticles Functionalized with NIPAM-Based Hydrogels on the Release of Cytochrome C Gels anisotropy gold cytochrome C NIPAm nanostructures PEG |
| title | The Influence of Differently Shaped Gold Nanoparticles Functionalized with NIPAM-Based Hydrogels on the Release of Cytochrome C |
| title_full | The Influence of Differently Shaped Gold Nanoparticles Functionalized with NIPAM-Based Hydrogels on the Release of Cytochrome C |
| title_fullStr | The Influence of Differently Shaped Gold Nanoparticles Functionalized with NIPAM-Based Hydrogels on the Release of Cytochrome C |
| title_full_unstemmed | The Influence of Differently Shaped Gold Nanoparticles Functionalized with NIPAM-Based Hydrogels on the Release of Cytochrome C |
| title_short | The Influence of Differently Shaped Gold Nanoparticles Functionalized with NIPAM-Based Hydrogels on the Release of Cytochrome C |
| title_sort | influence of differently shaped gold nanoparticles functionalized with nipam based hydrogels on the release of cytochrome c |
| topic | anisotropy gold cytochrome C NIPAm nanostructures PEG |
| url | https://www.mdpi.com/2310-2861/3/4/42 |
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