Production of 177Lu in No Carrier Added (NCA) form by Irradiation of Natural and Enriched Target in Tehran Research Reactor for Nuclear Medicine Approch
: 177Lu owing to its favorable nuclidic characteristics, such as tl/2=6/73d and Eβ(max)= 497 keV and ease of its large-scale production using medium flux research reactors, is an attractive radionuclide for various therapeutic applications. In this study 177Lu with the radionuclide purity of >...
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| Format: | Article |
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Nuclear Science and Technology Research Institute
2016-11-01
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| Series: | مجله علوم و فنون هسته‌ای |
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| Online Access: | https://jonsat.nstri.ir/article_121_eb8ca2f669b9846991f27d6a6f2bced8.pdf |
| _version_ | 1827955569129947136 |
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| author | N Salek M Shansaei Zafarghandi S Shirvani Arani A Bahrami-Samani M Ghanadi-Maragheh |
| author_facet | N Salek M Shansaei Zafarghandi S Shirvani Arani A Bahrami-Samani M Ghanadi-Maragheh |
| author_sort | N Salek |
| collection | DOAJ |
| description | : 177Lu owing to its favorable nuclidic characteristics, such as tl/2=6/73d and Eβ(max)= 497 keV and ease of its large-scale production using medium flux research reactors, is an attractive radionuclide for various therapeutic applications. In this study 177Lu with the radionuclide purity of >99.9% was obtained by thermal neutron bombardment (4×1013n/cm2.s) of 176Yb target through the 176Yb(n,γ) 177Yb 177Lu process. The method of separation of 177Lu from macro amount of Yb target was based on extraction chromatographic (EXC). The extractant used in resin was di(2-ethylhexyl) orthophosphoric acid (HDEHP). Finally, (177Lu) with a specific activity of 230.1 MBq (6.22 mCi) was prepared without the addiation of any carrier radionuclide. The process provides a separation yield of 75% 177Lu and a decontamination factor of 2000. The whole process to prepare NCA 177Lu takes almost 1.5 hours. The resultant NCA 177Lu can be used for preparation of NCA 177Lu labeled radiotherapeuticals. |
| first_indexed | 2024-04-09T14:49:28Z |
| format | Article |
| id | doaj.art-fd9252b627de4048b6f5b437fa77ede4 |
| institution | Directory Open Access Journal |
| issn | 1735-1871 2676-5861 |
| language | fas |
| last_indexed | 2024-04-09T14:49:28Z |
| publishDate | 2016-11-01 |
| publisher | Nuclear Science and Technology Research Institute |
| record_format | Article |
| series | مجله علوم و فنون هسته‌ای |
| spelling | doaj.art-fd9252b627de4048b6f5b437fa77ede42023-05-02T10:24:16ZfasNuclear Science and Technology Research Instituteمجله علوم و فنون هسته‌ای1735-18712676-58612016-11-0137318121Production of 177Lu in No Carrier Added (NCA) form by Irradiation of Natural and Enriched Target in Tehran Research Reactor for Nuclear Medicine ApprochN Salek0M Shansaei Zafarghandi1S Shirvani Arani2A Bahrami-Samani3M Ghanadi-Maragheh4پژوهشگاه علوم و فنون هسته‌ای، سازمان انرژی اتمی ایران،دانشکده مهندسی انرژی و فیزیک، دانشگاه صنعتی امیرکبیرپژوهشکده‌ی چرخه سوخت هسته‌ای، پژوهشگاه علوم و فنون هسته‌ایپژوهشکده‌ی چرخه‌ی سوخت هسته‌ای، پژوهشگاه علوم و فنون هسته‌ایپژوهشکده‌ی چرخه‌ی سوخت هسته‌ای، پژوهشگاه علوم و فنون هسته‌ای: 177Lu owing to its favorable nuclidic characteristics, such as tl/2=6/73d and Eβ(max)= 497 keV and ease of its large-scale production using medium flux research reactors, is an attractive radionuclide for various therapeutic applications. In this study 177Lu with the radionuclide purity of >99.9% was obtained by thermal neutron bombardment (4×1013n/cm2.s) of 176Yb target through the 176Yb(n,γ) 177Yb 177Lu process. The method of separation of 177Lu from macro amount of Yb target was based on extraction chromatographic (EXC). The extractant used in resin was di(2-ethylhexyl) orthophosphoric acid (HDEHP). Finally, (177Lu) with a specific activity of 230.1 MBq (6.22 mCi) was prepared without the addiation of any carrier radionuclide. The process provides a separation yield of 75% 177Lu and a decontamination factor of 2000. The whole process to prepare NCA 177Lu takes almost 1.5 hours. The resultant NCA 177Lu can be used for preparation of NCA 177Lu labeled radiotherapeuticals.https://jonsat.nstri.ir/article_121_eb8ca2f669b9846991f27d6a6f2bced8.pdfradiotherapyno-carrier added (nca)lutethiumlabeling |
| spellingShingle | N Salek M Shansaei Zafarghandi S Shirvani Arani A Bahrami-Samani M Ghanadi-Maragheh Production of 177Lu in No Carrier Added (NCA) form by Irradiation of Natural and Enriched Target in Tehran Research Reactor for Nuclear Medicine Approch مجله علوم و فنون هسته‌ای radiotherapy no-carrier added (nca) lutethium labeling |
| title | Production of 177Lu in No Carrier Added (NCA) form by Irradiation of Natural and Enriched Target in Tehran Research Reactor for Nuclear Medicine Approch |
| title_full | Production of 177Lu in No Carrier Added (NCA) form by Irradiation of Natural and Enriched Target in Tehran Research Reactor for Nuclear Medicine Approch |
| title_fullStr | Production of 177Lu in No Carrier Added (NCA) form by Irradiation of Natural and Enriched Target in Tehran Research Reactor for Nuclear Medicine Approch |
| title_full_unstemmed | Production of 177Lu in No Carrier Added (NCA) form by Irradiation of Natural and Enriched Target in Tehran Research Reactor for Nuclear Medicine Approch |
| title_short | Production of 177Lu in No Carrier Added (NCA) form by Irradiation of Natural and Enriched Target in Tehran Research Reactor for Nuclear Medicine Approch |
| title_sort | production of 177lu in no carrier added nca form by irradiation of natural and enriched target in tehran research reactor for nuclear medicine approch |
| topic | radiotherapy no-carrier added (nca) lutethium labeling |
| url | https://jonsat.nstri.ir/article_121_eb8ca2f669b9846991f27d6a6f2bced8.pdf |
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