Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors
Pancreatic progenitors (PPs) can be derived from human pluripotent stem cells in vitro but efficiency of differentiation varies, making it hard to sort for insulin-producing cells. Here, the authors use a proteomic approach to identify the secretory granule membrane glycoprotein 2 as a marker for PD...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00561-0 |
| _version_ | 1818978860716261376 |
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| author | Kathryn F. Cogger Ankit Sinha Farida Sarangi Emily C. McGaugh Diane Saunders Craig Dorrell Salvador Mejia-Guerrero Yasaman Aghazadeh Jillian L. Rourke Robert A. Screaton Markus Grompe Philip R. Streeter Alvin C. Powers Marcela Brissova Thomas Kislinger M. Cristina Nostro |
| author_facet | Kathryn F. Cogger Ankit Sinha Farida Sarangi Emily C. McGaugh Diane Saunders Craig Dorrell Salvador Mejia-Guerrero Yasaman Aghazadeh Jillian L. Rourke Robert A. Screaton Markus Grompe Philip R. Streeter Alvin C. Powers Marcela Brissova Thomas Kislinger M. Cristina Nostro |
| author_sort | Kathryn F. Cogger |
| collection | DOAJ |
| description | Pancreatic progenitors (PPs) can be derived from human pluripotent stem cells in vitro but efficiency of differentiation varies, making it hard to sort for insulin-producing cells. Here, the authors use a proteomic approach to identify the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ PPs. |
| first_indexed | 2024-12-20T16:50:21Z |
| format | Article |
| id | doaj.art-fd9272cedfac4963a9e8b1e7fd7c10ad |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:50:21Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fd9272cedfac4963a9e8b1e7fd7c10ad2022-12-21T19:32:51ZengNature PortfolioNature Communications2041-17232017-08-018111310.1038/s41467-017-00561-0Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitorsKathryn F. Cogger0Ankit Sinha1Farida Sarangi2Emily C. McGaugh3Diane Saunders4Craig Dorrell5Salvador Mejia-Guerrero6Yasaman Aghazadeh7Jillian L. Rourke8Robert A. Screaton9Markus Grompe10Philip R. Streeter11Alvin C. Powers12Marcela Brissova13Thomas Kislinger14M. Cristina Nostro15Toronto General Hospital Research Institute, University Health NetworkDepartment of Medical Biophysics, University of TorontoToronto General Hospital Research Institute, University Health NetworkToronto General Hospital Research Institute, University Health NetworkDepartment of Molecular Physiology and Biophysics, Vanderbilt UniversityOregon Stem Cell Center, Oregon Health and Science UniversityPrincess Margaret Cancer Centre, University Health NetworkToronto General Hospital Research Institute, University Health NetworkSunnybrook Research InstituteSunnybrook Research InstituteOregon Stem Cell Center, Oregon Health and Science UniversityOregon Stem Cell Center, Oregon Health and Science UniversityDepartment of Molecular Physiology and Biophysics, Vanderbilt UniversityDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical CenterDepartment of Medical Biophysics, University of TorontoToronto General Hospital Research Institute, University Health NetworkPancreatic progenitors (PPs) can be derived from human pluripotent stem cells in vitro but efficiency of differentiation varies, making it hard to sort for insulin-producing cells. Here, the authors use a proteomic approach to identify the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ PPs.https://doi.org/10.1038/s41467-017-00561-0 |
| spellingShingle | Kathryn F. Cogger Ankit Sinha Farida Sarangi Emily C. McGaugh Diane Saunders Craig Dorrell Salvador Mejia-Guerrero Yasaman Aghazadeh Jillian L. Rourke Robert A. Screaton Markus Grompe Philip R. Streeter Alvin C. Powers Marcela Brissova Thomas Kislinger M. Cristina Nostro Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors Nature Communications |
| title | Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors |
| title_full | Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors |
| title_fullStr | Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors |
| title_full_unstemmed | Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors |
| title_short | Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors |
| title_sort | glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors |
| url | https://doi.org/10.1038/s41467-017-00561-0 |
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