Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

Rapid generation of drug-resistant mutations in HIV-1 reverse transcriptase (RT), a prime target for anti-HIV therapy, poses a major impediment to effective anti-HIV treatment. Our previous efforts have led to the development of two novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) with...

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Bibliographic Details
Main Authors: Yang Yang, Dongwei Kang, Laura A Nguyen, Zachary B Smithline, Christophe Pannecouque, Peng Zhan, Xinyong Liu, Thomas A Steitz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
HIV-1
reverse transcriptase
non-nucleoside inhibitor
drug resistance
x-ray crystallography
piperidine-substituted thiophene[3,2-d]pyrimidine
Online Access:https://elifesciences.org/articles/36340

Internet

https://elifesciences.org/articles/36340

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