An Attempt to Predict the Preferential Cellular Orientation in Any Complex Mechanical Environment
Cells respond to their mechanical environment in different ways: while their response in terms of differentiation and proliferation has been widely studied, the question of the direction in which cells align when subject to a complex mechanical loading in a 3D environment is still widely open. In th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-02-01
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| Series: | Bioengineering |
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| Online Access: | http://www.mdpi.com/2306-5354/4/1/16 |
| _version_ | 1797719467971575808 |
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| author | Cédric P Laurent Jean-François Ganghoffer Rachid Rahouadj |
| author_facet | Cédric P Laurent Jean-François Ganghoffer Rachid Rahouadj |
| author_sort | Cédric P Laurent |
| collection | DOAJ |
| description | Cells respond to their mechanical environment in different ways: while their response in terms of differentiation and proliferation has been widely studied, the question of the direction in which cells align when subject to a complex mechanical loading in a 3D environment is still widely open. In the present paper, we formulate the hypothesis that the cells orientate in the direction of unitary stretch computed from the right Cauchy-Green tensor in a given mechanical environment. The implications of this hypothesis are studied in different simple cases corresponding to either the available in vitro experimental data or physiological conditions, starting from finite element analysis results to computed preferential cellular orientation. The present contribution is a first step to the formulation of a deeper understanding of the orientation of cells within or at the surface of any 3D scaffold subject to any complex load. It is believed that these initial preferential directions have strong implications as far as the anisotropy of biological structures is concerned. |
| first_indexed | 2024-03-12T09:06:18Z |
| format | Article |
| id | doaj.art-fd9589ec1c984be7ab496084453fcc1a |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-12T09:06:18Z |
| publishDate | 2017-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-fd9589ec1c984be7ab496084453fcc1a2023-09-02T15:21:54ZengMDPI AGBioengineering2306-53542017-02-01411610.3390/bioengineering4010016bioengineering4010016An Attempt to Predict the Preferential Cellular Orientation in Any Complex Mechanical EnvironmentCédric P Laurent0Jean-François Ganghoffer1Rachid Rahouadj2CNRS, LEMTA, UMR 7563, Université de Lorraine, 2 Avenue de la Forêt de Haye, 54502 Vandoeuvre-lès-Nancy, FranceCNRS, LEMTA, UMR 7563, Université de Lorraine, 2 Avenue de la Forêt de Haye, 54502 Vandoeuvre-lès-Nancy, FranceCNRS, LEMTA, UMR 7563, Université de Lorraine, 2 Avenue de la Forêt de Haye, 54502 Vandoeuvre-lès-Nancy, FranceCells respond to their mechanical environment in different ways: while their response in terms of differentiation and proliferation has been widely studied, the question of the direction in which cells align when subject to a complex mechanical loading in a 3D environment is still widely open. In the present paper, we formulate the hypothesis that the cells orientate in the direction of unitary stretch computed from the right Cauchy-Green tensor in a given mechanical environment. The implications of this hypothesis are studied in different simple cases corresponding to either the available in vitro experimental data or physiological conditions, starting from finite element analysis results to computed preferential cellular orientation. The present contribution is a first step to the formulation of a deeper understanding of the orientation of cells within or at the surface of any 3D scaffold subject to any complex load. It is believed that these initial preferential directions have strong implications as far as the anisotropy of biological structures is concerned.http://www.mdpi.com/2306-5354/4/1/16mechanobiologycell mechanicsmechanosensingscaffoldnumerical simulation |
| spellingShingle | Cédric P Laurent Jean-François Ganghoffer Rachid Rahouadj An Attempt to Predict the Preferential Cellular Orientation in Any Complex Mechanical Environment Bioengineering mechanobiology cell mechanics mechanosensing scaffold numerical simulation |
| title | An Attempt to Predict the Preferential Cellular Orientation in Any Complex Mechanical Environment |
| title_full | An Attempt to Predict the Preferential Cellular Orientation in Any Complex Mechanical Environment |
| title_fullStr | An Attempt to Predict the Preferential Cellular Orientation in Any Complex Mechanical Environment |
| title_full_unstemmed | An Attempt to Predict the Preferential Cellular Orientation in Any Complex Mechanical Environment |
| title_short | An Attempt to Predict the Preferential Cellular Orientation in Any Complex Mechanical Environment |
| title_sort | attempt to predict the preferential cellular orientation in any complex mechanical environment |
| topic | mechanobiology cell mechanics mechanosensing scaffold numerical simulation |
| url | http://www.mdpi.com/2306-5354/4/1/16 |
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