Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation
Cartilage has poor regeneration capacity due to the scarcity of endogenous stem cells, its low metabolic activity and the avascular environment. Repair strategies vary widely, including microfracture, autologous or allogenic tissue implantation, and in vitro engineered tissues of autologous origin....
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Format: | Article |
Language: | English |
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BMC
2013-01-01
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Series: | Biological Research |
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Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000400015&lng=en&tlng=en |
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author | Fredy Montoya Fernando Martínez María García-Robles Carolina Balmaceda-Aguilera Ximena Koch Federico Rodríguez Carmen Silva-Álvarez Katterine Salazar Viviana Ulloa Francisco Nualart |
author_facet | Fredy Montoya Fernando Martínez María García-Robles Carolina Balmaceda-Aguilera Ximena Koch Federico Rodríguez Carmen Silva-Álvarez Katterine Salazar Viviana Ulloa Francisco Nualart |
author_sort | Fredy Montoya |
collection | DOAJ |
description | Cartilage has poor regeneration capacity due to the scarcity of endogenous stem cells, its low metabolic activity and the avascular environment. Repair strategies vary widely, including microfracture, autologous or allogenic tissue implantation, and in vitro engineered tissues of autologous origin. However, unlike the advances that have been made over more than two decades with more complex organs, including vascular, cardiac or bone tissues, similar advances in tissue engineering for cartilage repair are lacking. Although the inherent characteristics of cartilage tissue, such as the lack of vascularity and low cellular diversity, suggest that it would be one of the more simple tissues to be engineered, its functional weight-bearing role and implant viability and adaptation make this type of repair more complex. Over the last decade several therapeutic approaches and innovative techniques show promise for lasting and functional regeneration of hyaline cartilage. Here we will analyze the main strategies for cartilage regeneration and discuss our experience. |
first_indexed | 2024-12-21T08:09:41Z |
format | Article |
id | doaj.art-fd95d67d62e04336a4b50906e2d6bd45 |
institution | Directory Open Access Journal |
issn | 0716-9760 |
language | English |
last_indexed | 2024-12-21T08:09:41Z |
publishDate | 2013-01-01 |
publisher | BMC |
record_format | Article |
series | Biological Research |
spelling | doaj.art-fd95d67d62e04336a4b50906e2d6bd452022-12-21T19:10:42ZengBMCBiological Research0716-97602013-01-0146444145110.4067/S0716-97602013000400015S0716-97602013000400015Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiationFredy Montoya0Fernando Martínez1María García-Robles2Carolina Balmaceda-Aguilera3Ximena Koch4Federico Rodríguez5Carmen Silva-Álvarez6Katterine Salazar7Viviana Ulloa8Francisco Nualart9Concepcion UniversityUniversity of ConcepcionUniversity of ConcepcionUniversity of ConcepcionUniversity of ConcepcionUniversity of ConcepcionUniversity of ConcepcionUniversity of ConcepcionUniversity of ConcepcionUniversity of ConcepcionCartilage has poor regeneration capacity due to the scarcity of endogenous stem cells, its low metabolic activity and the avascular environment. Repair strategies vary widely, including microfracture, autologous or allogenic tissue implantation, and in vitro engineered tissues of autologous origin. However, unlike the advances that have been made over more than two decades with more complex organs, including vascular, cardiac or bone tissues, similar advances in tissue engineering for cartilage repair are lacking. Although the inherent characteristics of cartilage tissue, such as the lack of vascularity and low cellular diversity, suggest that it would be one of the more simple tissues to be engineered, its functional weight-bearing role and implant viability and adaptation make this type of repair more complex. Over the last decade several therapeutic approaches and innovative techniques show promise for lasting and functional regeneration of hyaline cartilage. Here we will analyze the main strategies for cartilage regeneration and discuss our experience.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000400015&lng=en&tlng=enCartilagelesionmicrofracturestem cells |
spellingShingle | Fredy Montoya Fernando Martínez María García-Robles Carolina Balmaceda-Aguilera Ximena Koch Federico Rodríguez Carmen Silva-Álvarez Katterine Salazar Viviana Ulloa Francisco Nualart Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation Biological Research Cartilage lesion microfracture stem cells |
title | Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation |
title_full | Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation |
title_fullStr | Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation |
title_full_unstemmed | Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation |
title_short | Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation |
title_sort | clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation |
topic | Cartilage lesion microfracture stem cells |
url | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000400015&lng=en&tlng=en |
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