Correlation between Serum Ferritin, Serum Cystatin C, and Renal Function in Children with β Thalassemia Major
Renal dysfunction caused by iron overload is characterized by an increase in ferritin and cystatin C levels. The objective of this study was to determine the correlation between ferritin, cystatin C, and renal function in children with β thalassemia major. A cross-sectional observational analytic st...
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| Format: | Article |
| Language: | English |
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Universitas Padjajaran
2019-12-01
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| Series: | Majalah Kedokteran Bandung |
| Subjects: | |
| Online Access: | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/1666 |
| _version_ | 1831808091660746752 |
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| author | Suci Saptyuni Permadi Lelani Renarti Dedi Rachmadi |
| author_facet | Suci Saptyuni Permadi Lelani Renarti Dedi Rachmadi |
| author_sort | Suci Saptyuni Permadi |
| collection | DOAJ |
| description | Renal dysfunction caused by iron overload is characterized by an increase in ferritin and cystatin C levels. The objective of this study was to determine the correlation between ferritin, cystatin C, and renal function in children with β thalassemia major. A cross-sectional observational analytic study was conducted in September 2018 on 34 children with β thalassemia major in Dr. Hasan Sadikin General Hospital. Ferritin and cystatin C levels were documented and the estimated glomerular filtration rate (eGFR) was calculated using the Schwartz formula. Statistical tests were performed using Rank Spearman and Point Biserial with p value of <0.05 considered significant. the median ferritin level, cystatin C level, and eGFR of the subjects were 2,818 ng/mL (95% CI: 2,505–3,977), 209.9±121.5 (95% CI: 167.5–252.3), and 185.5 mL/min /1.73 m2 (95% CI: 173.6–208.2), respectively. Correlations were sought between serum ferritin and eGFR (r=0.132, p=0.229), between cystatin C and eGFR: r=0.3012, p=0.041, and between ferritin and cystatin C: r=0.433, p=0.011. No correlation was found between ferritin and renal function whereas serum cystatin C presented a positive correlation with renal function. A strong correlation was found between ferritin and cystatin C. Serum ferritin and cystatin C are promising biomarkers to assist in monitoring renal function in children with β thalasemia major. |
| first_indexed | 2024-12-22T20:17:06Z |
| format | Article |
| id | doaj.art-fd978f72b95d4d66bf3fab062b770c0c |
| institution | Directory Open Access Journal |
| issn | 0126-074X 2338-6223 |
| language | English |
| last_indexed | 2024-12-22T20:17:06Z |
| publishDate | 2019-12-01 |
| publisher | Universitas Padjajaran |
| record_format | Article |
| series | Majalah Kedokteran Bandung |
| spelling | doaj.art-fd978f72b95d4d66bf3fab062b770c0c2022-12-21T18:13:56ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X2338-62232019-12-0151316016410.15395/mkb.v51n3.16661131Correlation between Serum Ferritin, Serum Cystatin C, and Renal Function in Children with β Thalassemia MajorSuci Saptyuni Permadi0Lelani Renarti1Dedi Rachmadi2RSUD Gunung Jati CirebonDepartment of Child Health Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungDepartment of Child Health Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungRenal dysfunction caused by iron overload is characterized by an increase in ferritin and cystatin C levels. The objective of this study was to determine the correlation between ferritin, cystatin C, and renal function in children with β thalassemia major. A cross-sectional observational analytic study was conducted in September 2018 on 34 children with β thalassemia major in Dr. Hasan Sadikin General Hospital. Ferritin and cystatin C levels were documented and the estimated glomerular filtration rate (eGFR) was calculated using the Schwartz formula. Statistical tests were performed using Rank Spearman and Point Biserial with p value of <0.05 considered significant. the median ferritin level, cystatin C level, and eGFR of the subjects were 2,818 ng/mL (95% CI: 2,505–3,977), 209.9±121.5 (95% CI: 167.5–252.3), and 185.5 mL/min /1.73 m2 (95% CI: 173.6–208.2), respectively. Correlations were sought between serum ferritin and eGFR (r=0.132, p=0.229), between cystatin C and eGFR: r=0.3012, p=0.041, and between ferritin and cystatin C: r=0.433, p=0.011. No correlation was found between ferritin and renal function whereas serum cystatin C presented a positive correlation with renal function. A strong correlation was found between ferritin and cystatin C. Serum ferritin and cystatin C are promising biomarkers to assist in monitoring renal function in children with β thalasemia major.http://journal.fk.unpad.ac.id/index.php/mkb/article/view/1666cystatin c, ferritin, renal function, β talasemia major children |
| spellingShingle | Suci Saptyuni Permadi Lelani Renarti Dedi Rachmadi Correlation between Serum Ferritin, Serum Cystatin C, and Renal Function in Children with β Thalassemia Major Majalah Kedokteran Bandung cystatin c, ferritin, renal function, β talasemia major children |
| title | Correlation between Serum Ferritin, Serum Cystatin C, and Renal Function in Children with β Thalassemia Major |
| title_full | Correlation between Serum Ferritin, Serum Cystatin C, and Renal Function in Children with β Thalassemia Major |
| title_fullStr | Correlation between Serum Ferritin, Serum Cystatin C, and Renal Function in Children with β Thalassemia Major |
| title_full_unstemmed | Correlation between Serum Ferritin, Serum Cystatin C, and Renal Function in Children with β Thalassemia Major |
| title_short | Correlation between Serum Ferritin, Serum Cystatin C, and Renal Function in Children with β Thalassemia Major |
| title_sort | correlation between serum ferritin serum cystatin c and renal function in children with β thalassemia major |
| topic | cystatin c, ferritin, renal function, β talasemia major children |
| url | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/1666 |
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