Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
Lactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the authors show that LPS or Salmonella infection enhances glycolytic metabolism in bone marrow neutrophils, resulting in lactate production, which increases endothelial barrier permeability and mobilizati...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17402-2 |
| _version_ | 1818344122850738176 |
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| author | Eman Khatib-Massalha Suditi Bhattacharya Hassan Massalha Adi Biram Karin Golan Orit Kollet Anju Kumari Francesca Avemaria Ekaterina Petrovich-Kopitman Shiri Gur-Cohen Tomer Itkin Isabell Brandenburger Asaf Spiegel Ziv Shulman Zachary Gerhart-Hines Shalev Itzkovitz Matthias Gunzer Stefan Offermanns Ronen Alon Amiram Ariel Tsvee Lapidot |
| author_facet | Eman Khatib-Massalha Suditi Bhattacharya Hassan Massalha Adi Biram Karin Golan Orit Kollet Anju Kumari Francesca Avemaria Ekaterina Petrovich-Kopitman Shiri Gur-Cohen Tomer Itkin Isabell Brandenburger Asaf Spiegel Ziv Shulman Zachary Gerhart-Hines Shalev Itzkovitz Matthias Gunzer Stefan Offermanns Ronen Alon Amiram Ariel Tsvee Lapidot |
| author_sort | Eman Khatib-Massalha |
| collection | DOAJ |
| description | Lactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the authors show that LPS or Salmonella infection enhances glycolytic metabolism in bone marrow neutrophils, resulting in lactate production, which increases endothelial barrier permeability and mobilization of these neutrophils by targeting endothelial GPR81. |
| first_indexed | 2024-12-13T16:41:28Z |
| format | Article |
| id | doaj.art-fd9905e2c6a74145a36f74cbae797fa7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:41:28Z |
| publishDate | 2020-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fd9905e2c6a74145a36f74cbae797fa72022-12-21T23:38:16ZengNature PortfolioNature Communications2041-17232020-07-0111111810.1038/s41467-020-17402-2Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signalingEman Khatib-Massalha0Suditi Bhattacharya1Hassan Massalha2Adi Biram3Karin Golan4Orit Kollet5Anju Kumari6Francesca Avemaria7Ekaterina Petrovich-Kopitman8Shiri Gur-Cohen9Tomer Itkin10Isabell Brandenburger11Asaf Spiegel12Ziv Shulman13Zachary Gerhart-Hines14Shalev Itzkovitz15Matthias Gunzer16Stefan Offermanns17Ronen Alon18Amiram Ariel19Tsvee Lapidot20Department of Immunology, Weizmann Institute of ScienceDepartment of Immunology, Weizmann Institute of ScienceDepartment of Molecular Cell Biology, Weizmann Institute of ScienceDepartment of Immunology, Weizmann Institute of ScienceDepartment of Immunology, Weizmann Institute of ScienceDepartment of Immunology, Weizmann Institute of ScienceDepartment of Immunology, Weizmann Institute of ScienceDepartment of Immunology, Weizmann Institute of ScienceDepartment of Immunology, Weizmann Institute of ScienceDepartment of Immunology, Weizmann Institute of ScienceDepartment of Immunology, Weizmann Institute of ScienceDepartment of Pharmacology, Max-Planck-Institute for Heart and Lung ResearchDepartment of Immunology, Weizmann Institute of ScienceDepartment of Immunology, Weizmann Institute of ScienceNovo Nordisk Foundation Center for Basic Metabolic Research, University of CopenhagenDepartment of Molecular Cell Biology, Weizmann Institute of ScienceInstitute for Experimental Immunology and Imaging, University Hospital, University Duisburg-EssenDepartment of Pharmacology, Max-Planck-Institute for Heart and Lung ResearchDepartment of Immunology, Weizmann Institute of ScienceDepartment of Human Biology, University of HaifaDepartment of Immunology, Weizmann Institute of ScienceLactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the authors show that LPS or Salmonella infection enhances glycolytic metabolism in bone marrow neutrophils, resulting in lactate production, which increases endothelial barrier permeability and mobilization of these neutrophils by targeting endothelial GPR81.https://doi.org/10.1038/s41467-020-17402-2 |
| spellingShingle | Eman Khatib-Massalha Suditi Bhattacharya Hassan Massalha Adi Biram Karin Golan Orit Kollet Anju Kumari Francesca Avemaria Ekaterina Petrovich-Kopitman Shiri Gur-Cohen Tomer Itkin Isabell Brandenburger Asaf Spiegel Ziv Shulman Zachary Gerhart-Hines Shalev Itzkovitz Matthias Gunzer Stefan Offermanns Ronen Alon Amiram Ariel Tsvee Lapidot Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling Nature Communications |
| title | Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling |
| title_full | Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling |
| title_fullStr | Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling |
| title_full_unstemmed | Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling |
| title_short | Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling |
| title_sort | lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial gpr81 signaling |
| url | https://doi.org/10.1038/s41467-020-17402-2 |
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