Incorporation of paclitaxel in mesenchymal stem cells using nanoengineering upregulates antioxidant response, CXCR4 expression and enhances tumor homing

Incorporation of paclitaxel in mesenchymal stem cells using nanoengineering upregulates antioxidant response, CXCR4 expression and enhances tumor homing

Engineered mesenchymal stem cells (MSCs) have been investigated extensively for gene delivery and, more recently, for targeted small molecule delivery. While preclinical studies demonstrate the potential of MSCs for targeted delivery, clinical studies suggest that tumor homing of native MSCs may be...

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Bibliographic Details
Main Authors: Swayam Prabha, Carmen Merali, Drishti Sehgal, Emmanuelle Nicolas, Nitu Bhaskar, Magda Flores, Shubhmita Bhatnagar, Susheel Kumar Nethi, Carlos A. Barrero, Salim Merali, Jayanth Panyam
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Materials Today Bio
Subjects:
Mesenchymal stem cells
Tumor homing
Nanoengineering
Targeted drug delivery
Drug resistance
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006423000273

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