Mesenchymal Stem Cells and Atopic Dermatitis: A Review
Mesenchymal stem/stromal cells (MSCs) are stromal-derived non-hematopoietic progenitor cells that reside in and can be expanded from various tissues sources of adult and neonatal origin, such as the bone marrow, umbilical cord, umbilical cord blood, adipose tissue, amniotic fluid, placenta, dental p...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-05-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.00326/full |
| _version_ | 1819103247130951680 |
|---|---|
| author | Sérgio Ricardo Teixeira Daltro Cássio Santana Meira Ivanilson Pimenta Santos Ricardo Ribeiro dos Santos Ricardo Ribeiro dos Santos Ricardo Ribeiro dos Santos Milena Botelho Pereira Soares Milena Botelho Pereira Soares Milena Botelho Pereira Soares |
| author_facet | Sérgio Ricardo Teixeira Daltro Cássio Santana Meira Ivanilson Pimenta Santos Ricardo Ribeiro dos Santos Ricardo Ribeiro dos Santos Ricardo Ribeiro dos Santos Milena Botelho Pereira Soares Milena Botelho Pereira Soares Milena Botelho Pereira Soares |
| author_sort | Sérgio Ricardo Teixeira Daltro |
| collection | DOAJ |
| description | Mesenchymal stem/stromal cells (MSCs) are stromal-derived non-hematopoietic progenitor cells that reside in and can be expanded from various tissues sources of adult and neonatal origin, such as the bone marrow, umbilical cord, umbilical cord blood, adipose tissue, amniotic fluid, placenta, dental pulp and skin. The discovery of the immunosuppressing action of MSCs on T cells has opened new perspectives for their use as a therapeutic agent for immune-mediated disorders, including allergies. Atopic dermatitis (AD), a chronic and relapsing skin disorder that affects up to 20% of children and up to 3% of adults worldwide, is characterized by pruritic eczematous lesions, impaired cutaneous barrier function, Th2 type immune hyperactivation and, frequently, elevation of serum immunoglobulin E levels. Although, in the dermatology field, the application of MSCs as a therapeutic agent was initiated using the concept of cell replacement for skin defects and wound healing, accumulating evidence have shown that MSC-mediated immunomodulation can be applicable to the treatment of inflammatory/allergic skin disorders. Here we reviewed the pre-clinical and clinical studies and possible biological mechanisms of MSCs as a therapeutic tool for the treatment of atopic dermatitis. |
| first_indexed | 2024-12-22T01:47:25Z |
| format | Article |
| id | doaj.art-fd999ad7be19495680b604708ba660bc |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-22T01:47:25Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-fd999ad7be19495680b604708ba660bc2022-12-21T18:43:01ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-05-01810.3389/fcell.2020.00326539211Mesenchymal Stem Cells and Atopic Dermatitis: A ReviewSérgio Ricardo Teixeira Daltro0Cássio Santana Meira1Ivanilson Pimenta Santos2Ricardo Ribeiro dos Santos3Ricardo Ribeiro dos Santos4Ricardo Ribeiro dos Santos5Milena Botelho Pereira Soares6Milena Botelho Pereira Soares7Milena Botelho Pereira Soares8Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilHealth Institute of Technology, National Industrial Learning Service - Integrated Manufacturing and Technology Campus (SENAI-CIMATEC), Salvador, BrazilNational Institute of Science and Technology for Regenerative Medicine (INCT-REGENERA), Rio de Janeiro, BrazilGonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilHealth Institute of Technology, National Industrial Learning Service - Integrated Manufacturing and Technology Campus (SENAI-CIMATEC), Salvador, BrazilNational Institute of Science and Technology for Regenerative Medicine (INCT-REGENERA), Rio de Janeiro, BrazilMesenchymal stem/stromal cells (MSCs) are stromal-derived non-hematopoietic progenitor cells that reside in and can be expanded from various tissues sources of adult and neonatal origin, such as the bone marrow, umbilical cord, umbilical cord blood, adipose tissue, amniotic fluid, placenta, dental pulp and skin. The discovery of the immunosuppressing action of MSCs on T cells has opened new perspectives for their use as a therapeutic agent for immune-mediated disorders, including allergies. Atopic dermatitis (AD), a chronic and relapsing skin disorder that affects up to 20% of children and up to 3% of adults worldwide, is characterized by pruritic eczematous lesions, impaired cutaneous barrier function, Th2 type immune hyperactivation and, frequently, elevation of serum immunoglobulin E levels. Although, in the dermatology field, the application of MSCs as a therapeutic agent was initiated using the concept of cell replacement for skin defects and wound healing, accumulating evidence have shown that MSC-mediated immunomodulation can be applicable to the treatment of inflammatory/allergic skin disorders. Here we reviewed the pre-clinical and clinical studies and possible biological mechanisms of MSCs as a therapeutic tool for the treatment of atopic dermatitis.https://www.frontiersin.org/article/10.3389/fcell.2020.00326/fullmesenchymal stem/stromal cellsatopic dermatitisatopic eczemaimmunomodulationinflammatory skin diseases |
| spellingShingle | Sérgio Ricardo Teixeira Daltro Cássio Santana Meira Ivanilson Pimenta Santos Ricardo Ribeiro dos Santos Ricardo Ribeiro dos Santos Ricardo Ribeiro dos Santos Milena Botelho Pereira Soares Milena Botelho Pereira Soares Milena Botelho Pereira Soares Mesenchymal Stem Cells and Atopic Dermatitis: A Review Frontiers in Cell and Developmental Biology mesenchymal stem/stromal cells atopic dermatitis atopic eczema immunomodulation inflammatory skin diseases |
| title | Mesenchymal Stem Cells and Atopic Dermatitis: A Review |
| title_full | Mesenchymal Stem Cells and Atopic Dermatitis: A Review |
| title_fullStr | Mesenchymal Stem Cells and Atopic Dermatitis: A Review |
| title_full_unstemmed | Mesenchymal Stem Cells and Atopic Dermatitis: A Review |
| title_short | Mesenchymal Stem Cells and Atopic Dermatitis: A Review |
| title_sort | mesenchymal stem cells and atopic dermatitis a review |
| topic | mesenchymal stem/stromal cells atopic dermatitis atopic eczema immunomodulation inflammatory skin diseases |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.00326/full |
| work_keys_str_mv | AT sergioricardoteixeiradaltro mesenchymalstemcellsandatopicdermatitisareview AT cassiosantanameira mesenchymalstemcellsandatopicdermatitisareview AT ivanilsonpimentasantos mesenchymalstemcellsandatopicdermatitisareview AT ricardoribeirodossantos mesenchymalstemcellsandatopicdermatitisareview AT ricardoribeirodossantos mesenchymalstemcellsandatopicdermatitisareview AT ricardoribeirodossantos mesenchymalstemcellsandatopicdermatitisareview AT milenabotelhopereirasoares mesenchymalstemcellsandatopicdermatitisareview AT milenabotelhopereirasoares mesenchymalstemcellsandatopicdermatitisareview AT milenabotelhopereirasoares mesenchymalstemcellsandatopicdermatitisareview |