Drug Development in Soft Tissue Sarcomas: Novel Targets and Recent Early Phase Trial Results
Soft tissue sarcomas are a heterogeneous group of rare malignancies with few effective standard therapies. Our understanding of the underlying biology driving tumorigenesis in these mesenchymal tumors have led to a growth in drug development for soft tissue sarcomas. This review focuses on novel tar...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Innovative Healthcare Institute
2020-05-01
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| Series: | Journal of Immunotherapy and Precision Oncology |
| Subjects: | |
| Online Access: | https://jipo.org/doi/pdf/10.36401/JIPO-20-4 |
| _version_ | 1797962763245453312 |
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| author | Ella Achenbach David Lai Shiraj Sen |
| author_facet | Ella Achenbach David Lai Shiraj Sen |
| author_sort | Ella Achenbach |
| collection | DOAJ |
| description | Soft tissue sarcomas are a heterogeneous group of rare malignancies with few effective standard therapies. Our understanding of the underlying biology driving tumorigenesis in these mesenchymal tumors have led to a growth in drug development for soft tissue sarcomas. This review focuses on novel targets in soft tissue sarcomas, describes early clinical trial results of drugs directed at these targets, and discusses the data surrounding the use of these compounds in clinical practice and rationale for possible future US Food and Drug Administration approvals. |
| first_indexed | 2024-04-11T01:17:59Z |
| format | Article |
| id | doaj.art-fd9a66686bd94bd4870f02b63082a2fb |
| institution | Directory Open Access Journal |
| issn | 2666-2345 2590-017X |
| language | English |
| last_indexed | 2024-04-11T01:17:59Z |
| publishDate | 2020-05-01 |
| publisher | Innovative Healthcare Institute |
| record_format | Article |
| series | Journal of Immunotherapy and Precision Oncology |
| spelling | doaj.art-fd9a66686bd94bd4870f02b63082a2fb2023-01-03T19:12:57ZengInnovative Healthcare InstituteJournal of Immunotherapy and Precision Oncology2666-23452590-017X2020-05-01838910.36401/JIPO-20-4i2590-017X-3-2-83Drug Development in Soft Tissue Sarcomas: Novel Targets and Recent Early Phase Trial ResultsElla AchenbachDavid LaiShiraj SenSoft tissue sarcomas are a heterogeneous group of rare malignancies with few effective standard therapies. Our understanding of the underlying biology driving tumorigenesis in these mesenchymal tumors have led to a growth in drug development for soft tissue sarcomas. This review focuses on novel targets in soft tissue sarcomas, describes early clinical trial results of drugs directed at these targets, and discusses the data surrounding the use of these compounds in clinical practice and rationale for possible future US Food and Drug Administration approvals.https://jipo.org/doi/pdf/10.36401/JIPO-20-4sarcomadrug developmentclinical trials |
| spellingShingle | Ella Achenbach David Lai Shiraj Sen Drug Development in Soft Tissue Sarcomas: Novel Targets and Recent Early Phase Trial Results Journal of Immunotherapy and Precision Oncology sarcoma drug development clinical trials |
| title | Drug Development in Soft Tissue Sarcomas: Novel Targets and Recent Early Phase Trial Results |
| title_full | Drug Development in Soft Tissue Sarcomas: Novel Targets and Recent Early Phase Trial Results |
| title_fullStr | Drug Development in Soft Tissue Sarcomas: Novel Targets and Recent Early Phase Trial Results |
| title_full_unstemmed | Drug Development in Soft Tissue Sarcomas: Novel Targets and Recent Early Phase Trial Results |
| title_short | Drug Development in Soft Tissue Sarcomas: Novel Targets and Recent Early Phase Trial Results |
| title_sort | drug development in soft tissue sarcomas novel targets and recent early phase trial results |
| topic | sarcoma drug development clinical trials |
| url | https://jipo.org/doi/pdf/10.36401/JIPO-20-4 |
| work_keys_str_mv | AT ellaachenbach drugdevelopmentinsofttissuesarcomasnoveltargetsandrecentearlyphasetrialresults AT davidlai drugdevelopmentinsofttissuesarcomasnoveltargetsandrecentearlyphasetrialresults AT shirajsen drugdevelopmentinsofttissuesarcomasnoveltargetsandrecentearlyphasetrialresults |