Congenital peritoneopericardial diaphragmatic hernia in a family of Persian cats
Case series summary The congenital midline defects of peritoneopericardial diaphragmatic hernia (PPDH) and omphalocele are believed to be related developmental defects, and have both been described in cats and dogs. This case series describes multiple cases of PPDH and omphalocele in related cats. T...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-10-01
|
| Series: | Journal of Feline Medicine and Surgery Open Reports |
| Online Access: | https://doi.org/10.1177/2055116918804305 |
| _version_ | 1819079679306366976 |
|---|---|
| author | Carol Margolis Maja Zakošek Pipan Jolie Demchur Matan Or Paula Henthorn Margret L Casal |
| author_facet | Carol Margolis Maja Zakošek Pipan Jolie Demchur Matan Or Paula Henthorn Margret L Casal |
| author_sort | Carol Margolis |
| collection | DOAJ |
| description | Case series summary The congenital midline defects of peritoneopericardial diaphragmatic hernia (PPDH) and omphalocele are believed to be related developmental defects, and have both been described in cats and dogs. This case series describes multiple cases of PPDH and omphalocele in related cats. The majority of cats affected with midline defects (PPDH or omphalocele) were male, consistent with previous reports of male overrepresentation. Relevance and novel information This is the first report of a family of Persian cats affected by PPDH and/or omphalocele. Clinical findings and pedigree information are suggestive of an autosomal recessive mode of inheritance. However, other modes of inheritance cannot be ruled out owing to limited sample size. The findings in this family and previous reports of Persians affected by PPDH warrant further investigation. Based on this information, recommendations for breeding populations of Persians and long-haired cats should include thoracic radiographs to screen for PPDH until a DNA-based genetic test is available. |
| first_indexed | 2024-12-21T19:32:49Z |
| format | Article |
| id | doaj.art-fd9d3786f47246f39758952e90f91633 |
| institution | Directory Open Access Journal |
| issn | 2055-1169 |
| language | English |
| last_indexed | 2024-12-21T19:32:49Z |
| publishDate | 2018-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Feline Medicine and Surgery Open Reports |
| spelling | doaj.art-fd9d3786f47246f39758952e90f916332022-12-21T18:52:41ZengSAGE PublishingJournal of Feline Medicine and Surgery Open Reports2055-11692018-10-01410.1177/2055116918804305Congenital peritoneopericardial diaphragmatic hernia in a family of Persian catsCarol Margolis0Maja Zakošek Pipan1Jolie Demchur2Matan Or3Paula Henthorn4Margret L Casal5Section of Medical Genetics, Department of Clinical Sciences and Advanced Medicine, MJ Ryan Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA, USAClinic for Reproduction and Large Animals, Veterinary Faculty, University of Ljubljana, Ljubljana, SloveniaSection of Medical Genetics, Department of Clinical Sciences and Advanced Medicine, MJ Ryan Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA, USASection of Medical Genetics, Department of Clinical Sciences and Advanced Medicine, MJ Ryan Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA, USASection of Medical Genetics, Department of Clinical Sciences and Advanced Medicine, MJ Ryan Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA, USASection of Medical Genetics, Department of Clinical Sciences and Advanced Medicine, MJ Ryan Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA, USACase series summary The congenital midline defects of peritoneopericardial diaphragmatic hernia (PPDH) and omphalocele are believed to be related developmental defects, and have both been described in cats and dogs. This case series describes multiple cases of PPDH and omphalocele in related cats. The majority of cats affected with midline defects (PPDH or omphalocele) were male, consistent with previous reports of male overrepresentation. Relevance and novel information This is the first report of a family of Persian cats affected by PPDH and/or omphalocele. Clinical findings and pedigree information are suggestive of an autosomal recessive mode of inheritance. However, other modes of inheritance cannot be ruled out owing to limited sample size. The findings in this family and previous reports of Persians affected by PPDH warrant further investigation. Based on this information, recommendations for breeding populations of Persians and long-haired cats should include thoracic radiographs to screen for PPDH until a DNA-based genetic test is available.https://doi.org/10.1177/2055116918804305 |
| spellingShingle | Carol Margolis Maja Zakošek Pipan Jolie Demchur Matan Or Paula Henthorn Margret L Casal Congenital peritoneopericardial diaphragmatic hernia in a family of Persian cats Journal of Feline Medicine and Surgery Open Reports |
| title | Congenital peritoneopericardial diaphragmatic hernia in a family of Persian cats |
| title_full | Congenital peritoneopericardial diaphragmatic hernia in a family of Persian cats |
| title_fullStr | Congenital peritoneopericardial diaphragmatic hernia in a family of Persian cats |
| title_full_unstemmed | Congenital peritoneopericardial diaphragmatic hernia in a family of Persian cats |
| title_short | Congenital peritoneopericardial diaphragmatic hernia in a family of Persian cats |
| title_sort | congenital peritoneopericardial diaphragmatic hernia in a family of persian cats |
| url | https://doi.org/10.1177/2055116918804305 |
| work_keys_str_mv | AT carolmargolis congenitalperitoneopericardialdiaphragmaticherniainafamilyofpersiancats AT majazakosekpipan congenitalperitoneopericardialdiaphragmaticherniainafamilyofpersiancats AT joliedemchur congenitalperitoneopericardialdiaphragmaticherniainafamilyofpersiancats AT matanor congenitalperitoneopericardialdiaphragmaticherniainafamilyofpersiancats AT paulahenthorn congenitalperitoneopericardialdiaphragmaticherniainafamilyofpersiancats AT margretlcasal congenitalperitoneopericardialdiaphragmaticherniainafamilyofpersiancats |