Increased Ratio of Global O-GlcNAcylation to Tau Phosphorylation at Thr212 Site Is Associated With Better Memory Function in Patients With Type 2 Diabetes

Increased Ratio of Global O-GlcNAcylation to Tau Phosphorylation at Thr212 Site Is Associated With Better Memory Function in Patients With Type 2 Diabetes

Objective: Aberrant O-GlcNAc modification has been implicated in type 2 diabetes mellitus (T2DM) and the pathogenesis of neurodegenerative diseases via competition with tau phosphorylation. We aimed to investigate the association between global O-GlcNAcylation, tau phosphorylation levels and mild co...

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Bibliographic Details
Main Authors: Rong Huang, Sai Tian, Jing Han, Rongrong Cai, Hongyan Lin, Dan Guo, Jiaqi Wang, Shaohua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Physiology
Subjects:
tau protein
O-GlcNAcylation
phosphorylation
mild cognitive impairment
type 2 diabetes mellitus
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00110/full

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