Motor Subtype as a Predictor of Future Working Memory Performance in Idiopathic Parkinson's Disease.
Parkinson's disease is a progressive neurodegenerative disorder associated with reduced spatial and verbal working memory ability. There are two established motor subtypes of PD, tremor dominant (TD) and postural instability and gait difficulty (PIGD). This study used structural equation modell...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4807780?pdf=render |
| _version_ | 1818027838315429888 |
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| author | Andrew R Johnson Romola S Bucks Robert T Kane Meghan G Thomas Natalie Gasson Andrea M Loftus |
| author_facet | Andrew R Johnson Romola S Bucks Robert T Kane Meghan G Thomas Natalie Gasson Andrea M Loftus |
| author_sort | Andrew R Johnson |
| collection | DOAJ |
| description | Parkinson's disease is a progressive neurodegenerative disorder associated with reduced spatial and verbal working memory ability. There are two established motor subtypes of PD, tremor dominant (TD) and postural instability and gait difficulty (PIGD). This study used structural equation modelling to explore the longitudinal relationship between the two subtypes and working memory assessed at a 2-year follow-up. The study comprised 84 males and 30 females (N = 114), aged between 39 and 85 (M = 64.82, SD = 9.23) with confirmed PD. There was no significant relationship between motor subtype at Time 1 and working memory at Time 2. Postural symptom severity at Time 1 predicted Time 2 spatial working memory for the PIGD subtype (p = .011) but not the TD subtype. Tremor symptoms were not associated with Time 2 working memory in either subtype. Predictive significance of Time 1 postural symptoms only in the PIGD subtype suggests an interaction between symptom dominance (subtype) and symptom severity that future subtyping should consider. This study demonstrates a predictive relationship between postural difficulties and working memory performance assessed at a 2-year follow-up. Establishing physical symptoms as predictors of cognitive change could have significant clinical importance. |
| first_indexed | 2024-12-10T04:54:15Z |
| format | Article |
| id | doaj.art-fd9f418aba2d48e8bef5182845592409 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T04:54:15Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fd9f418aba2d48e8bef51828455924092022-12-22T02:01:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01113e015253410.1371/journal.pone.0152534Motor Subtype as a Predictor of Future Working Memory Performance in Idiopathic Parkinson's Disease.Andrew R JohnsonRomola S BucksRobert T KaneMeghan G ThomasNatalie GassonAndrea M LoftusParkinson's disease is a progressive neurodegenerative disorder associated with reduced spatial and verbal working memory ability. There are two established motor subtypes of PD, tremor dominant (TD) and postural instability and gait difficulty (PIGD). This study used structural equation modelling to explore the longitudinal relationship between the two subtypes and working memory assessed at a 2-year follow-up. The study comprised 84 males and 30 females (N = 114), aged between 39 and 85 (M = 64.82, SD = 9.23) with confirmed PD. There was no significant relationship between motor subtype at Time 1 and working memory at Time 2. Postural symptom severity at Time 1 predicted Time 2 spatial working memory for the PIGD subtype (p = .011) but not the TD subtype. Tremor symptoms were not associated with Time 2 working memory in either subtype. Predictive significance of Time 1 postural symptoms only in the PIGD subtype suggests an interaction between symptom dominance (subtype) and symptom severity that future subtyping should consider. This study demonstrates a predictive relationship between postural difficulties and working memory performance assessed at a 2-year follow-up. Establishing physical symptoms as predictors of cognitive change could have significant clinical importance.http://europepmc.org/articles/PMC4807780?pdf=render |
| spellingShingle | Andrew R Johnson Romola S Bucks Robert T Kane Meghan G Thomas Natalie Gasson Andrea M Loftus Motor Subtype as a Predictor of Future Working Memory Performance in Idiopathic Parkinson's Disease. PLoS ONE |
| title | Motor Subtype as a Predictor of Future Working Memory Performance in Idiopathic Parkinson's Disease. |
| title_full | Motor Subtype as a Predictor of Future Working Memory Performance in Idiopathic Parkinson's Disease. |
| title_fullStr | Motor Subtype as a Predictor of Future Working Memory Performance in Idiopathic Parkinson's Disease. |
| title_full_unstemmed | Motor Subtype as a Predictor of Future Working Memory Performance in Idiopathic Parkinson's Disease. |
| title_short | Motor Subtype as a Predictor of Future Working Memory Performance in Idiopathic Parkinson's Disease. |
| title_sort | motor subtype as a predictor of future working memory performance in idiopathic parkinson s disease |
| url | http://europepmc.org/articles/PMC4807780?pdf=render |
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