Assessment of the Adverse Health Effects of Aflatoxin Exposure from Unpackaged Peanut Oil in Guangdong, China
Aflatoxins are liver carcinogens and are common contaminants in unpackaged peanut (UPP) oil. However, the health risks associated with consuming aflatoxins in UPP oil remain unclear. In this study, aflatoxin contamination in 143 UPP oil samples from Guangdong Province were assessed via liquid chroma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/15/11/646 |
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| author | Zhini He Zihui Chen Yunying Mo Xiaodan Lu Yanheng Luo Shaoliang Lin Yanxu Zhong Junfeng Deng Shixiong Zheng Lei Xia Hang Wu Michael N. Routledge Ye Hong Xiaoyu Xian Xingfen Yang Yunyun Gong |
| author_facet | Zhini He Zihui Chen Yunying Mo Xiaodan Lu Yanheng Luo Shaoliang Lin Yanxu Zhong Junfeng Deng Shixiong Zheng Lei Xia Hang Wu Michael N. Routledge Ye Hong Xiaoyu Xian Xingfen Yang Yunyun Gong |
| author_sort | Zhini He |
| collection | DOAJ |
| description | Aflatoxins are liver carcinogens and are common contaminants in unpackaged peanut (UPP) oil. However, the health risks associated with consuming aflatoxins in UPP oil remain unclear. In this study, aflatoxin contamination in 143 UPP oil samples from Guangdong Province were assessed via liquid chromatography–tandem mass spectrometry (LC-MS). We also recruited 168 human subjects, who consumed this oil, to measure their liver functions and lipid metabolism status. Aflatoxin B1 (AFB1) was detected in 79.72% of the UPP oil samples, with levels ranging from 0.02 to 174.13 μg/kg. The average daily human intake of AFB1 from UPP oil was 3.14 ng/kg·bw/day; therefore, the incidence of liver cancer, caused by intake of 1 ng/kg·bw/day AFB1, was estimated to be 5.32 cases out of every 100,000 persons per year. Meanwhile, Hepatitis B virus (HBV) infection and AFB1 exposure exerted a synergistic effect to cause liver dysfunction. In addition, the triglycerides (TG) abnormal rate was statistically significant when using AFB1 to estimate daily intake (EDI) quartile spacing grouping (<i>p</i> = 0.011). In conclusion, high aflatoxin exposure may exacerbate the harmful effects of HBV infection on liver function. Contamination of UPP oil with aflatoxins in Guangdong urgently requires more attention, and public health management of the consumer population is urgently required. |
| first_indexed | 2024-03-09T16:25:09Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-09T16:25:09Z |
| publishDate | 2023-11-01 |
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| record_format | Article |
| series | Toxins |
| spelling | doaj.art-fd9f6e1854444926833d97e1a19152e92023-11-24T15:09:34ZengMDPI AGToxins2072-66512023-11-01151164610.3390/toxins15110646Assessment of the Adverse Health Effects of Aflatoxin Exposure from Unpackaged Peanut Oil in Guangdong, ChinaZhini He0Zihui Chen1Yunying Mo2Xiaodan Lu3Yanheng Luo4Shaoliang Lin5Yanxu Zhong6Junfeng Deng7Shixiong Zheng8Lei Xia9Hang Wu10Michael N. Routledge11Ye Hong12Xiaoyu Xian13Xingfen Yang14Yunyun Gong15Food Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou 510515, ChinaInstitute of Public Health, Guangzhou 510060, ChinaFood Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou 510515, ChinaFood Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou 510515, ChinaZhaoqing Center for Disease Control and Prevention, Zhaoqing 526060, ChinaZhaoqing Center for Disease Control and Prevention, Zhaoqing 526060, ChinaFood Safety Monitoring and Evaluation Department, Guangxi Zhuang Autonomous Region Centre for Disease Control and Prevention, Nanning 530028, ChinaFood Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou 510515, ChinaFood Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou 510515, ChinaSchool of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UKSchool of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UKLeicester Medical School, University of Leicester, Leicester LE1 7RH, UKFood Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou 510515, ChinaFood Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou 510515, ChinaFood Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou 510515, ChinaSchool of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UKAflatoxins are liver carcinogens and are common contaminants in unpackaged peanut (UPP) oil. However, the health risks associated with consuming aflatoxins in UPP oil remain unclear. In this study, aflatoxin contamination in 143 UPP oil samples from Guangdong Province were assessed via liquid chromatography–tandem mass spectrometry (LC-MS). We also recruited 168 human subjects, who consumed this oil, to measure their liver functions and lipid metabolism status. Aflatoxin B1 (AFB1) was detected in 79.72% of the UPP oil samples, with levels ranging from 0.02 to 174.13 μg/kg. The average daily human intake of AFB1 from UPP oil was 3.14 ng/kg·bw/day; therefore, the incidence of liver cancer, caused by intake of 1 ng/kg·bw/day AFB1, was estimated to be 5.32 cases out of every 100,000 persons per year. Meanwhile, Hepatitis B virus (HBV) infection and AFB1 exposure exerted a synergistic effect to cause liver dysfunction. In addition, the triglycerides (TG) abnormal rate was statistically significant when using AFB1 to estimate daily intake (EDI) quartile spacing grouping (<i>p</i> = 0.011). In conclusion, high aflatoxin exposure may exacerbate the harmful effects of HBV infection on liver function. Contamination of UPP oil with aflatoxins in Guangdong urgently requires more attention, and public health management of the consumer population is urgently required.https://www.mdpi.com/2072-6651/15/11/646aflatoxinsunpackaged peanut oilmargin of exposureliver functionsynergistic effect |
| spellingShingle | Zhini He Zihui Chen Yunying Mo Xiaodan Lu Yanheng Luo Shaoliang Lin Yanxu Zhong Junfeng Deng Shixiong Zheng Lei Xia Hang Wu Michael N. Routledge Ye Hong Xiaoyu Xian Xingfen Yang Yunyun Gong Assessment of the Adverse Health Effects of Aflatoxin Exposure from Unpackaged Peanut Oil in Guangdong, China Toxins aflatoxins unpackaged peanut oil margin of exposure liver function synergistic effect |
| title | Assessment of the Adverse Health Effects of Aflatoxin Exposure from Unpackaged Peanut Oil in Guangdong, China |
| title_full | Assessment of the Adverse Health Effects of Aflatoxin Exposure from Unpackaged Peanut Oil in Guangdong, China |
| title_fullStr | Assessment of the Adverse Health Effects of Aflatoxin Exposure from Unpackaged Peanut Oil in Guangdong, China |
| title_full_unstemmed | Assessment of the Adverse Health Effects of Aflatoxin Exposure from Unpackaged Peanut Oil in Guangdong, China |
| title_short | Assessment of the Adverse Health Effects of Aflatoxin Exposure from Unpackaged Peanut Oil in Guangdong, China |
| title_sort | assessment of the adverse health effects of aflatoxin exposure from unpackaged peanut oil in guangdong china |
| topic | aflatoxins unpackaged peanut oil margin of exposure liver function synergistic effect |
| url | https://www.mdpi.com/2072-6651/15/11/646 |
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