Research Progress in the Field of Gambogic Acid and Its Derivatives as Antineoplastic Drugs
Gambogic acid (GA) is a natural product with a wide range of pharmacological properties. It plays an important role in inhibiting tumor growth. A large number of GA derivatives have been designed and prepared to improve its shortcomings, such as poor water solubility, low bioavailability, poor stabi...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/9/2937 |
| _version_ | 1827672045527236608 |
|---|---|
| author | Meng Li Fali Su Mingtao Zhu Huan Zhang Yuxin Wei Yang Zhao Jianmin Li Shaowa Lv |
| author_facet | Meng Li Fali Su Mingtao Zhu Huan Zhang Yuxin Wei Yang Zhao Jianmin Li Shaowa Lv |
| author_sort | Meng Li |
| collection | DOAJ |
| description | Gambogic acid (GA) is a natural product with a wide range of pharmacological properties. It plays an important role in inhibiting tumor growth. A large number of GA derivatives have been designed and prepared to improve its shortcomings, such as poor water solubility, low bioavailability, poor stability, and adverse drug effects. So far, GA has been utilized to develop a variety of active derivatives with improved water solubility and bioavailability through structural modification. This article summarized the progress in pharmaceutical chemistry of GA derivatives to provide a reference and basis for further study on structural modifications of GA and expansion of its clinical applications. |
| first_indexed | 2024-03-10T03:54:13Z |
| format | Article |
| id | doaj.art-fda0a8a4019d498ba93b73f24e3b9ae3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:54:13Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fda0a8a4019d498ba93b73f24e3b9ae32023-11-23T08:51:53ZengMDPI AGMolecules1420-30492022-05-01279293710.3390/molecules27092937Research Progress in the Field of Gambogic Acid and Its Derivatives as Antineoplastic DrugsMeng Li0Fali Su1Mingtao Zhu2Huan Zhang3Yuxin Wei4Yang Zhao5Jianmin Li6Shaowa Lv7Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaThe First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaGambogic acid (GA) is a natural product with a wide range of pharmacological properties. It plays an important role in inhibiting tumor growth. A large number of GA derivatives have been designed and prepared to improve its shortcomings, such as poor water solubility, low bioavailability, poor stability, and adverse drug effects. So far, GA has been utilized to develop a variety of active derivatives with improved water solubility and bioavailability through structural modification. This article summarized the progress in pharmaceutical chemistry of GA derivatives to provide a reference and basis for further study on structural modifications of GA and expansion of its clinical applications.https://www.mdpi.com/1420-3049/27/9/2937Gambogic acidstructural modificationderivativeantitumor activitypolymer prodrug |
| spellingShingle | Meng Li Fali Su Mingtao Zhu Huan Zhang Yuxin Wei Yang Zhao Jianmin Li Shaowa Lv Research Progress in the Field of Gambogic Acid and Its Derivatives as Antineoplastic Drugs Molecules Gambogic acid structural modification derivative antitumor activity polymer prodrug |
| title | Research Progress in the Field of Gambogic Acid and Its Derivatives as Antineoplastic Drugs |
| title_full | Research Progress in the Field of Gambogic Acid and Its Derivatives as Antineoplastic Drugs |
| title_fullStr | Research Progress in the Field of Gambogic Acid and Its Derivatives as Antineoplastic Drugs |
| title_full_unstemmed | Research Progress in the Field of Gambogic Acid and Its Derivatives as Antineoplastic Drugs |
| title_short | Research Progress in the Field of Gambogic Acid and Its Derivatives as Antineoplastic Drugs |
| title_sort | research progress in the field of gambogic acid and its derivatives as antineoplastic drugs |
| topic | Gambogic acid structural modification derivative antitumor activity polymer prodrug |
| url | https://www.mdpi.com/1420-3049/27/9/2937 |
| work_keys_str_mv | AT mengli researchprogressinthefieldofgambogicacidanditsderivativesasantineoplasticdrugs AT falisu researchprogressinthefieldofgambogicacidanditsderivativesasantineoplasticdrugs AT mingtaozhu researchprogressinthefieldofgambogicacidanditsderivativesasantineoplasticdrugs AT huanzhang researchprogressinthefieldofgambogicacidanditsderivativesasantineoplasticdrugs AT yuxinwei researchprogressinthefieldofgambogicacidanditsderivativesasantineoplasticdrugs AT yangzhao researchprogressinthefieldofgambogicacidanditsderivativesasantineoplasticdrugs AT jianminli researchprogressinthefieldofgambogicacidanditsderivativesasantineoplasticdrugs AT shaowalv researchprogressinthefieldofgambogicacidanditsderivativesasantineoplasticdrugs |