Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy
Cardiovascular disease is the leading cause of death worldwide and bears an immense economic burden. Late-stage heart failure often requires total heart transplantation; however, due to donor shortages and lifelong immunosuppression, alternative cardiac regenerative therapies are in high demand. Hum...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.707890/full |
| _version_ | 1818823155009978368 |
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| author | Sophia E. Silver Sophia E. Silver Ryan W. Barrs Ryan W. Barrs Ying Mei Ying Mei |
| author_facet | Sophia E. Silver Sophia E. Silver Ryan W. Barrs Ryan W. Barrs Ying Mei Ying Mei |
| author_sort | Sophia E. Silver |
| collection | DOAJ |
| description | Cardiovascular disease is the leading cause of death worldwide and bears an immense economic burden. Late-stage heart failure often requires total heart transplantation; however, due to donor shortages and lifelong immunosuppression, alternative cardiac regenerative therapies are in high demand. Human pluripotent stem cells (hPSCs), including human embryonic and induced pluripotent stem cells, have emerged as a viable source of human cardiomyocytes for transplantation. Recent developments in several mammalian models of cardiac injury have provided strong evidence of the therapeutic potential of hPSC-derived cardiomyocytes (hPSC-CM), showing their ability to electromechanically integrate with host cardiac tissue and promote functional recovery. In this review, we will discuss recent developments in hPSC-CM differentiation and transplantation strategies for delivery to the heart. We will highlight the mechanisms through which hPSC-CMs contribute to heart repair, review major challenges in successful transplantation of hPSC-CMs, and present solutions that are being explored to address these limitations. We end with a discussion of the clinical use of hPSC-CMs, including hurdles to clinical translation, current clinical trials, and future perspectives on hPSC-CM transplantation. |
| first_indexed | 2024-12-18T23:35:28Z |
| format | Article |
| id | doaj.art-fda1131cedf04c25b725c5d378461664 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-18T23:35:28Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-fda1131cedf04c25b725c5d3784616642022-12-21T20:47:34ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-11-01810.3389/fcvm.2021.707890707890Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative TherapySophia E. Silver0Sophia E. Silver1Ryan W. Barrs2Ryan W. Barrs3Ying Mei4Ying Mei5Bioengineering Department, Clemson University, Clemson, SC, United StatesDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, United StatesBioengineering Department, Clemson University, Clemson, SC, United StatesDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, United StatesBioengineering Department, Clemson University, Clemson, SC, United StatesDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, United StatesCardiovascular disease is the leading cause of death worldwide and bears an immense economic burden. Late-stage heart failure often requires total heart transplantation; however, due to donor shortages and lifelong immunosuppression, alternative cardiac regenerative therapies are in high demand. Human pluripotent stem cells (hPSCs), including human embryonic and induced pluripotent stem cells, have emerged as a viable source of human cardiomyocytes for transplantation. Recent developments in several mammalian models of cardiac injury have provided strong evidence of the therapeutic potential of hPSC-derived cardiomyocytes (hPSC-CM), showing their ability to electromechanically integrate with host cardiac tissue and promote functional recovery. In this review, we will discuss recent developments in hPSC-CM differentiation and transplantation strategies for delivery to the heart. We will highlight the mechanisms through which hPSC-CMs contribute to heart repair, review major challenges in successful transplantation of hPSC-CMs, and present solutions that are being explored to address these limitations. We end with a discussion of the clinical use of hPSC-CMs, including hurdles to clinical translation, current clinical trials, and future perspectives on hPSC-CM transplantation.https://www.frontiersin.org/articles/10.3389/fcvm.2021.707890/fullhuman pluripotent stem cell-derived cardiomyocytescardiovascular diseasecell therapyregenerative medicinetissue engineering |
| spellingShingle | Sophia E. Silver Sophia E. Silver Ryan W. Barrs Ryan W. Barrs Ying Mei Ying Mei Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy Frontiers in Cardiovascular Medicine human pluripotent stem cell-derived cardiomyocytes cardiovascular disease cell therapy regenerative medicine tissue engineering |
| title | Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy |
| title_full | Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy |
| title_fullStr | Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy |
| title_full_unstemmed | Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy |
| title_short | Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy |
| title_sort | transplantation of human pluripotent stem cell derived cardiomyocytes for cardiac regenerative therapy |
| topic | human pluripotent stem cell-derived cardiomyocytes cardiovascular disease cell therapy regenerative medicine tissue engineering |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.707890/full |
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