Contribution of CNS cells in NeuroAIDS
NeuroAIDS is becoming a major health problem among AIDS patients and long-term HIV survivors. As per 2009 estimates of UNAIDS report, more than 34 million people have been infected with HIV out of which ≥ 50% show signs and symptoms of neuropsychiatric disorders. These disorders affect central nervo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2010-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2010;volume=2;issue=4;spage=300;epage=306;aulast=Verma |
| _version_ | 1819263977568337920 |
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| author | Ashish Swarup Verma Udai Pratap Singh Premendra Dhar Dwivedi Anchal Singh |
| author_facet | Ashish Swarup Verma Udai Pratap Singh Premendra Dhar Dwivedi Anchal Singh |
| author_sort | Ashish Swarup Verma |
| collection | DOAJ |
| description | NeuroAIDS is becoming a major health problem among AIDS patients and long-term HIV survivors. As per 2009 estimates of UNAIDS report, more than 34 million people have been infected with HIV out of which ≥ 50% show signs and symptoms of neuropsychiatric disorders. These disorders affect central nervous system (CNS) and peripheral nervous systems (PNS). CNS is one of the most protected organ systems in body which is protected by blood-brain barrier (BBB). Not only this, most of the cells of CNS are negative for receptors and co-receptors for HIV infections. Neurons have been found to be completely nonpermissive for HIV infection.These facts suggest that neurotoxicity could be an indirect mechanism responsible for neuropsychiatric complications. In this review, we will discuss the importance of different cell types of CNS and their contribution toward neurotoxicity. |
| first_indexed | 2024-12-23T20:22:10Z |
| format | Article |
| id | doaj.art-fda2f25777394426a0d7ba327ed72177 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 0976-4879 |
| language | English |
| last_indexed | 2024-12-23T20:22:10Z |
| publishDate | 2010-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-fda2f25777394426a0d7ba327ed721772022-12-21T17:32:31ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74060976-48792010-01-012430030610.4103/0975-7406.72129Contribution of CNS cells in NeuroAIDSAshish Swarup VermaUdai Pratap SinghPremendra Dhar DwivediAnchal SinghNeuroAIDS is becoming a major health problem among AIDS patients and long-term HIV survivors. As per 2009 estimates of UNAIDS report, more than 34 million people have been infected with HIV out of which ≥ 50% show signs and symptoms of neuropsychiatric disorders. These disorders affect central nervous system (CNS) and peripheral nervous systems (PNS). CNS is one of the most protected organ systems in body which is protected by blood-brain barrier (BBB). Not only this, most of the cells of CNS are negative for receptors and co-receptors for HIV infections. Neurons have been found to be completely nonpermissive for HIV infection.These facts suggest that neurotoxicity could be an indirect mechanism responsible for neuropsychiatric complications. In this review, we will discuss the importance of different cell types of CNS and their contribution toward neurotoxicity.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2010;volume=2;issue=4;spage=300;epage=306;aulast=VermaCentral nervous systemHIVNeuroAIDS |
| spellingShingle | Ashish Swarup Verma Udai Pratap Singh Premendra Dhar Dwivedi Anchal Singh Contribution of CNS cells in NeuroAIDS Journal of Pharmacy and Bioallied Sciences Central nervous system HIV NeuroAIDS |
| title | Contribution of CNS cells in NeuroAIDS |
| title_full | Contribution of CNS cells in NeuroAIDS |
| title_fullStr | Contribution of CNS cells in NeuroAIDS |
| title_full_unstemmed | Contribution of CNS cells in NeuroAIDS |
| title_short | Contribution of CNS cells in NeuroAIDS |
| title_sort | contribution of cns cells in neuroaids |
| topic | Central nervous system HIV NeuroAIDS |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2010;volume=2;issue=4;spage=300;epage=306;aulast=Verma |
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