Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry

Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry

Abstract Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated with multiple lipid traits in African ancestry. To further identify and localize loci with pleiotropic ef...

Full description

Bibliographic Details
Main Authors:	Abram Bunya Kamiza, Sounkou M. Touré, Feng Zhou, Opeyemi Soremekun, Cheickna Cissé, Mamadou Wélé, Aboubacrine M. Touré, Oyekanmi Nashiru, Manuel Corpas, Moffat Nyirenda, Amelia Crampin, Jeffrey Shaffer, Seydou Doumbia, Eleftheria Zeggini, Andrew P. Morris, Jennifer L. Asimit, Tinashe Chikowore, Segun Fatumo
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-023-41271-0

Similar Items

Correction: Udosen et al. Meta-Analysis and Multivariate GWAS Analyses in 80,950 Individuals of African Ancestry Identify Novel Variants Associated with Blood Pressure Traits. <i>Int. J. Mol. Sci.</i> 2023, <i>24</i>, 2164
by: Brenda Udosen, et al.
Published: (2024-04-01)

Meta-Analysis and Multivariate GWAS Analyses in 77,850 Individuals of African Ancestry Identify Novel Variants Associated with Blood Pressure Traits
by: Brenda Udosen, et al.
Published: (2023-01-01)

Genome-Wide Association and Mendelian Randomization Analysis Reveal the Causal Relationship Between White Blood Cell Subtypes and Asthma in Africans
by: Opeyemi Soremekun, et al.
Published: (2021-12-01)

Transcription-translation error: In-silico investigation of the structural and functional impact of deleterious single nucleotide polymorphisms in GULP1 gene
by: Opeyemi S. Soremekun, et al.
Published: (2021-01-01)

Multivariate GWAS analysis reveals loci associated with liver functions in continental African populations.
by: Chisom Soremekun, et al.
Published: (2023-01-01)

Multivariate GWAS analysis reveals loci associated with liver functions in continental African populations
by: Chisom Soremekun, et al.
Published: (2023-01-01)

Non-communicable diseases pandemic and precision medicine: Is Africa ready?
by: Tinashe Chikowore, et al.
Published: (2021-03-01)

Identification of differentially expressed genes present in the whole blood of Pulmonary Arterial Hypertension patients and control patients: An integrated bioinformatics approach
by: Chisom Ezenwa, et al.
Published: (2020-01-01)

Hepatitis B infection is causally associated with extrahepatic cancers: A Mendelian randomization study
by: Abram Bunya Kamiza, et al.
Published: (2022-05-01)

Leveraging information between multiple population groups and traits improves fine-mapping resolution
by: Feng Zhou, et al.
Published: (2023-11-01)

The causal effects of lipid traits on kidney function in Africans: bidirectional and multivariable Mendelian-randomization studyResearch in context
by: Christopher Kintu, et al.
Published: (2023-04-01)

Molecular Dynamic Simulation Reveals Structure Differences in <i>APOL1</i> Variants and Implication in Pathogenesis of Chronic Kidney Disease
by: Richard Mayanja, et al.
Published: (2022-08-01)

125.000 ditawar sertai program keusahawanan
by: Berita Harian , Zul lkhwan Muhammad
Published: (2012)

A Mendelian randomization study of genetic liability to post-traumatic stress disorder and risk of ischemic stroke
by: Opeyemi Soremekun, et al.
Published: (2023-07-01)

Genome-wide association analysis of cystatin-C kidney function in continental AfricaResearch in context
by: Richard Mayanja, et al.
Published: (2023-09-01)

Complimentary Methods for Multivariate Genome-Wide Association Study Identify New Susceptibility Genes for Blood Cell Traits
by: Segun Fatumo, et al.
Published: (2019-04-01)

Meta-analysis of African ancestry genome-wide association studies identified novel locus and validates multiple loci associated with kidney function
by: Christopher Kintu, et al.
Published: (2023-08-01)

Generalisation of genomic findings and applications of polygenic risk scores
by: Manuel Corpas, et al.
Published: (2023-07-01)

Type 2 diabetes prevalence, awareness, and risk factors in rural Mali: a cross-sectional study
by: Abdoulaye Diawara, et al.
Published: (2023-03-01)

Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Mali: a systematic review and meta-analysis
by: Fatoumata O. Maiga, et al.
Published: (2021-08-01)

Lipid traits and type 2 diabetes risk in African ancestry individuals: A Mendelian Randomization study
by: Opeyemi Soremekun, et al.
Published: (2022-04-01)

Plant succession on glacial moraines in the Arctic Brooks Range along a >125,000-year glacial chronosequence/toposequence
by: Shawnee A. Kasanke, et al.
Published: (2023-12-01)

Stratégies, audience et lectorat de la littérature diasporique ouest-africaine
by: Fatoumata Toure Cisse
Published: (2018-10-01)

Genetic heterogeneity in cardiovascular disease across ancestries: Insights for mechanisms and therapeutic intervention
by: Opeyemi Soremekun, et al.
Published: (2023-01-01)

An in-silico analysis of OGT gene association with diabetes mellitus
by: Abigail O. Ayodele, et al.
Published: (2024-03-01)

Computational biology and bioinformatics in Nigeria.
by: Segun A Fatumo, et al.
Published: (2014-04-01)

The opportunity in African genome resource for precision medicine
by: Segun Fatumo
Published: (2020-04-01)

Appendicular peritonitis in <it>situs inversus totalis</it>: a case report
by: Dia Abdarahmane, et al.
Published: (2010-05-01)

Template copy number and the sensitivity of quantitative PCR for Plasmodium falciparum in asymptomatic individuals
by: Trevor A. Thompson, et al.
Published: (2020-08-01)

ARIEL and AMELIA: testing for an accumulation of rare variants using next-generation sequencing data.
by: Asimit, J, et al.
Published: (2012)

Male-biased aganglionic megacolon in the TashT mouse line due to perturbation of silencer elements in a large gene desert of chromosome 10.
by: Karl-F Bergeron, et al.
Published: (2015-03-01)

Nutrient Patterns and Body Mass Index: A Comparative Longitudinal Analysis in Urban Black South African Adolescents and Adults
by: Gudani Mukoma, et al.
Published: (2023-02-01)

Les sepsis intra-abdominaux diffus post-operatoires: aspects épidémiologiques, diagnostiques et thérapeutiques au Service de Chirurgie Générale du CHU Aristide Le Dantec de Dakar
by: Alpha Oumar Touré, et al.
Published: (2014-03-01)

Minimal resilience and insurgent conflict: qualitative analysis of the resilience process in six primary health centres in central Mali
by: Valéry Ridde, et al.
Published: (2022-04-01)

Innovations in mutuality: challenges and learnings for the Universal Health Insurance Plan in Mali
by: Valéry Ridde, et al.
Published: (2022-03-01)

The role and contribution of civil society and community actors in COVID-19 prevention and control: the case of the COMVID COVID-19 movement in Burkina Faso
by: Charlemagne Tapsoba, et al.
Published: (2023-04-01)

Variations in the use of malaria preventive measures among pregnant women in Guinea: a secondary analysis of the 2012 and 2018 demographic and health surveys
by: Ibrahima Barry, et al.
Published: (2022-11-01)

Mendelian randomization studies on coronary artery disease: a systematic review and meta-analysis
by: Sarah Silva, et al.
Published: (2024-01-01)

Genome-wide association studies on coronary artery disease: A systematic review and implications for populations of different ancestries
by: Sarah Silva, et al.
Published: (2023-01-01)

Workshops: a great way to enhance and supplement a degree.
by: Segun Fatumo, et al.
Published: (2014-02-01)