Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives

Twenty novel cinnamamide derivatives were designed and synthesized using as lead compound pyrimorph, whose morpholine moiety was replaced by β-phenylethylamine. All the compounds were characterized by their spectroscopic data. The fungicidal and insecticidal activities were also evaluated. The preli...

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Main Authors: Yanjun Xu, Shuqing Wan, Huizhu Yuan, Bo Li, Xiaoli Yang, Yumei Xiao, Zhaohai Qin
Format: Article
Language:English
Published: MDPI AG 2011-10-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/16/11/8945/
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author Yanjun Xu
Shuqing Wan
Huizhu Yuan
Bo Li
Xiaoli Yang
Yumei Xiao
Zhaohai Qin
author_facet Yanjun Xu
Shuqing Wan
Huizhu Yuan
Bo Li
Xiaoli Yang
Yumei Xiao
Zhaohai Qin
author_sort Yanjun Xu
collection DOAJ
description Twenty novel cinnamamide derivatives were designed and synthesized using as lead compound pyrimorph, whose morpholine moiety was replaced by β-phenylethylamine. All the compounds were characterized by their spectroscopic data. The fungicidal and insecticidal activities were also evaluated. The preliminary results showed that all the title compounds had certain fungicidal activities against seven plant pathogens at a concentration of 50 μg/mL, and compounds 11a and 11l showed inhibition ratios of up to 90% against R. solani. Most of the title compounds exhibited moderate nematicidal activities. In general, the morpholine ring may be replaced by other amines and a chlorine atom in the pyridine ring is helpful to fungicidal activity.
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spelling doaj.art-fda56bbb1a6746899063a71e6efaa43e2022-12-21T22:27:49ZengMDPI AGMolecules1420-30492011-10-0116118945895710.3390/molecules16118945Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide DerivativesYanjun XuShuqing WanHuizhu YuanBo LiXiaoli YangYumei XiaoZhaohai QinTwenty novel cinnamamide derivatives were designed and synthesized using as lead compound pyrimorph, whose morpholine moiety was replaced by β-phenylethylamine. All the compounds were characterized by their spectroscopic data. The fungicidal and insecticidal activities were also evaluated. The preliminary results showed that all the title compounds had certain fungicidal activities against seven plant pathogens at a concentration of 50 μg/mL, and compounds 11a and 11l showed inhibition ratios of up to 90% against R. solani. Most of the title compounds exhibited moderate nematicidal activities. In general, the morpholine ring may be replaced by other amines and a chlorine atom in the pyridine ring is helpful to fungicidal activity.http://www.mdpi.com/1420-3049/16/11/8945/cinnamideβ-phenyl ethylaminefungicidal activityinsecticidal activity
spellingShingle Yanjun Xu
Shuqing Wan
Huizhu Yuan
Bo Li
Xiaoli Yang
Yumei Xiao
Zhaohai Qin
Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives
Molecules
cinnamide
β-phenyl ethylamine
fungicidal activity
insecticidal activity
title Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives
title_full Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives
title_fullStr Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives
title_full_unstemmed Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives
title_short Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives
title_sort design synthesis and antifungal insecticidal evaluation of novel cinnamide derivatives
topic cinnamide
β-phenyl ethylamine
fungicidal activity
insecticidal activity
url http://www.mdpi.com/1420-3049/16/11/8945/
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