Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives
Twenty novel cinnamamide derivatives were designed and synthesized using as lead compound pyrimorph, whose morpholine moiety was replaced by β-phenylethylamine. All the compounds were characterized by their spectroscopic data. The fungicidal and insecticidal activities were also evaluated. The preli...
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Format: | Article |
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MDPI AG
2011-10-01
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Series: | Molecules |
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Online Access: | http://www.mdpi.com/1420-3049/16/11/8945/ |
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author | Yanjun Xu Shuqing Wan Huizhu Yuan Bo Li Xiaoli Yang Yumei Xiao Zhaohai Qin |
author_facet | Yanjun Xu Shuqing Wan Huizhu Yuan Bo Li Xiaoli Yang Yumei Xiao Zhaohai Qin |
author_sort | Yanjun Xu |
collection | DOAJ |
description | Twenty novel cinnamamide derivatives were designed and synthesized using as lead compound pyrimorph, whose morpholine moiety was replaced by β-phenylethylamine. All the compounds were characterized by their spectroscopic data. The fungicidal and insecticidal activities were also evaluated. The preliminary results showed that all the title compounds had certain fungicidal activities against seven plant pathogens at a concentration of 50 μg/mL, and compounds 11a and 11l showed inhibition ratios of up to 90% against R. solani. Most of the title compounds exhibited moderate nematicidal activities. In general, the morpholine ring may be replaced by other amines and a chlorine atom in the pyridine ring is helpful to fungicidal activity. |
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format | Article |
id | doaj.art-fda56bbb1a6746899063a71e6efaa43e |
institution | Directory Open Access Journal |
issn | 1420-3049 |
language | English |
last_indexed | 2024-12-16T14:44:03Z |
publishDate | 2011-10-01 |
publisher | MDPI AG |
record_format | Article |
series | Molecules |
spelling | doaj.art-fda56bbb1a6746899063a71e6efaa43e2022-12-21T22:27:49ZengMDPI AGMolecules1420-30492011-10-0116118945895710.3390/molecules16118945Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide DerivativesYanjun XuShuqing WanHuizhu YuanBo LiXiaoli YangYumei XiaoZhaohai QinTwenty novel cinnamamide derivatives were designed and synthesized using as lead compound pyrimorph, whose morpholine moiety was replaced by β-phenylethylamine. All the compounds were characterized by their spectroscopic data. The fungicidal and insecticidal activities were also evaluated. The preliminary results showed that all the title compounds had certain fungicidal activities against seven plant pathogens at a concentration of 50 μg/mL, and compounds 11a and 11l showed inhibition ratios of up to 90% against R. solani. Most of the title compounds exhibited moderate nematicidal activities. In general, the morpholine ring may be replaced by other amines and a chlorine atom in the pyridine ring is helpful to fungicidal activity.http://www.mdpi.com/1420-3049/16/11/8945/cinnamideβ-phenyl ethylaminefungicidal activityinsecticidal activity |
spellingShingle | Yanjun Xu Shuqing Wan Huizhu Yuan Bo Li Xiaoli Yang Yumei Xiao Zhaohai Qin Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives Molecules cinnamide β-phenyl ethylamine fungicidal activity insecticidal activity |
title | Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives |
title_full | Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives |
title_fullStr | Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives |
title_full_unstemmed | Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives |
title_short | Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives |
title_sort | design synthesis and antifungal insecticidal evaluation of novel cinnamide derivatives |
topic | cinnamide β-phenyl ethylamine fungicidal activity insecticidal activity |
url | http://www.mdpi.com/1420-3049/16/11/8945/ |
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