The Impact of Post-Operative Radiotherapy in Early Stage (pT1-pT2N0M0) Oral Tongue Squamous Cell Carcinoma in Era of DOI
<i>Background:</i> This study investigated the role of depth of infiltration (DOI) as an independent prognosticator in early stage (T1-T2N0M0) oral cavity tumors and to evaluate the need of postoperative radiotherapy in the case of patients upstaged to pT3 for DOI > 10 mm in the absen...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/19/4851 |
| _version_ | 1797516757631500288 |
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| author | Daniela Alterio Pasqualina D’Urso Stefania Volpe Marta Tagliabue Rita De Berardinis Matteo Augugliaro Sara Gandini Fausto Antonio Maffini Roberto Bruschini Irene Turturici Stefano Riccio Luca Calabrese Alessia Farneti Anna Starzyńska Annamaria Ferrari Barbara Alicja Jereczek-Fossa Mohssen Ansarin Giuseppe Sanguineti |
| author_facet | Daniela Alterio Pasqualina D’Urso Stefania Volpe Marta Tagliabue Rita De Berardinis Matteo Augugliaro Sara Gandini Fausto Antonio Maffini Roberto Bruschini Irene Turturici Stefano Riccio Luca Calabrese Alessia Farneti Anna Starzyńska Annamaria Ferrari Barbara Alicja Jereczek-Fossa Mohssen Ansarin Giuseppe Sanguineti |
| author_sort | Daniela Alterio |
| collection | DOAJ |
| description | <i>Background:</i> This study investigated the role of depth of infiltration (DOI) as an independent prognosticator in early stage (T1-T2N0M0) oral cavity tumors and to evaluate the need of postoperative radiotherapy in the case of patients upstaged to pT3 for DOI > 10 mm in the absence of other risk factors. <i>Methods</i>: We performed a retrospective analysis on patients treated with surgery and re-staged according to the 8th edition of malignant tumors classification (TNM). The role of DOI as well as other clinical/pathological features was investigated at both univariable and multivariable analyses on overall survival (OS), disease free survival (DFS), relapse free survival (RFS), and local RFS. <i>Results</i>: Among the 94 included patients, 23 would have been upstaged to pT3 based on DOI. Multivariable analysis showed that DOI was not an independent prognostic factor for any of the considered outcomes. The presence of perineural invasion was associated with a significant worse RFS (<i>p</i> = 0.02) and LRFS (<i>p</i> = 0.04). PORT was found to be significantly associated with DFS (<i>p</i> = 0.04) and RFS (<i>p</i> = 0.06). <i>Conclusions</i>: The increasing DOI alone was not sufficient to impact the prognosis, and therefore, should not be sufficient to dictate PORT indications in early-stage patients upstaged on the sole basis of DOI. |
| first_indexed | 2024-03-10T07:05:20Z |
| format | Article |
| id | doaj.art-fda5df346299469ea2624dbea31eaa2a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T07:05:20Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-fda5df346299469ea2624dbea31eaa2a2023-11-22T15:53:18ZengMDPI AGCancers2072-66942021-09-011319485110.3390/cancers13194851The Impact of Post-Operative Radiotherapy in Early Stage (pT1-pT2N0M0) Oral Tongue Squamous Cell Carcinoma in Era of DOIDaniela Alterio0Pasqualina D’Urso1Stefania Volpe2Marta Tagliabue3Rita De Berardinis4Matteo Augugliaro5Sara Gandini6Fausto Antonio Maffini7Roberto Bruschini8Irene Turturici9Stefano Riccio10Luca Calabrese11Alessia Farneti12Anna Starzyńska13Annamaria Ferrari14Barbara Alicja Jereczek-Fossa15Mohssen Ansarin16Giuseppe Sanguineti17Division of Radiation Oncology, IEO European Institute of Oncology, IRCCS, 20141 Milan, ItalyDepartment of Radiation Oncology, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyDivision of Radiation Oncology, IEO European Institute of Oncology, IRCCS, 20141 Milan, ItalyDivision of Otolaryngology and Head and Neck Surgery, European Institute of Oncology IRCCS, 20141 Milan, ItalyDivision of Otolaryngology and Head and Neck Surgery, European Institute of Oncology IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO European Institute of Oncology, IRCCS, 20141 Milan, ItalyDepartment of Experimental Oncology, IEO European Institute of Oncology, IRCCS, 20141 Milan, ItalyDivision of Pathology, IEO European Institute of Oncology, IRCCS, 20141 Milan, ItalyDivision of Otolaryngology and Head and Neck Surgery, European Institute of Oncology IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO European Institute of Oncology, IRCCS, 20141 Milan, ItalyDivision of Otolaryngology and Head and Neck Surgery, European Institute of Oncology IRCCS, 20141 Milan, ItalyDivision of Otorhinolaryngology, San Maurizio Hospital, 39100 Bolzano, ItalyDepartment of Radiation Oncology, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyDepartment of Oral Surgery, Medical University of Gdańsk, 80-211 Gdańsk, PolandDivision of Radiation Oncology, IEO European Institute of Oncology, IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO European Institute of Oncology, IRCCS, 20141 Milan, ItalyDivision of Otolaryngology and Head and Neck Surgery, European Institute of Oncology IRCCS, 20141 Milan, ItalyDepartment of Radiation Oncology, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy<i>Background:</i> This study investigated the role of depth of infiltration (DOI) as an independent prognosticator in early stage (T1-T2N0M0) oral cavity tumors and to evaluate the need of postoperative radiotherapy in the case of patients upstaged to pT3 for DOI > 10 mm in the absence of other risk factors. <i>Methods</i>: We performed a retrospective analysis on patients treated with surgery and re-staged according to the 8th edition of malignant tumors classification (TNM). The role of DOI as well as other clinical/pathological features was investigated at both univariable and multivariable analyses on overall survival (OS), disease free survival (DFS), relapse free survival (RFS), and local RFS. <i>Results</i>: Among the 94 included patients, 23 would have been upstaged to pT3 based on DOI. Multivariable analysis showed that DOI was not an independent prognostic factor for any of the considered outcomes. The presence of perineural invasion was associated with a significant worse RFS (<i>p</i> = 0.02) and LRFS (<i>p</i> = 0.04). PORT was found to be significantly associated with DFS (<i>p</i> = 0.04) and RFS (<i>p</i> = 0.06). <i>Conclusions</i>: The increasing DOI alone was not sufficient to impact the prognosis, and therefore, should not be sufficient to dictate PORT indications in early-stage patients upstaged on the sole basis of DOI.https://www.mdpi.com/2072-6694/13/19/4851oral tongue cancerpost-operative radiotherapydepth of infiltrationperineural invasion |
| spellingShingle | Daniela Alterio Pasqualina D’Urso Stefania Volpe Marta Tagliabue Rita De Berardinis Matteo Augugliaro Sara Gandini Fausto Antonio Maffini Roberto Bruschini Irene Turturici Stefano Riccio Luca Calabrese Alessia Farneti Anna Starzyńska Annamaria Ferrari Barbara Alicja Jereczek-Fossa Mohssen Ansarin Giuseppe Sanguineti The Impact of Post-Operative Radiotherapy in Early Stage (pT1-pT2N0M0) Oral Tongue Squamous Cell Carcinoma in Era of DOI Cancers oral tongue cancer post-operative radiotherapy depth of infiltration perineural invasion |
| title | The Impact of Post-Operative Radiotherapy in Early Stage (pT1-pT2N0M0) Oral Tongue Squamous Cell Carcinoma in Era of DOI |
| title_full | The Impact of Post-Operative Radiotherapy in Early Stage (pT1-pT2N0M0) Oral Tongue Squamous Cell Carcinoma in Era of DOI |
| title_fullStr | The Impact of Post-Operative Radiotherapy in Early Stage (pT1-pT2N0M0) Oral Tongue Squamous Cell Carcinoma in Era of DOI |
| title_full_unstemmed | The Impact of Post-Operative Radiotherapy in Early Stage (pT1-pT2N0M0) Oral Tongue Squamous Cell Carcinoma in Era of DOI |
| title_short | The Impact of Post-Operative Radiotherapy in Early Stage (pT1-pT2N0M0) Oral Tongue Squamous Cell Carcinoma in Era of DOI |
| title_sort | impact of post operative radiotherapy in early stage pt1 pt2n0m0 oral tongue squamous cell carcinoma in era of doi |
| topic | oral tongue cancer post-operative radiotherapy depth of infiltration perineural invasion |
| url | https://www.mdpi.com/2072-6694/13/19/4851 |
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