CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES
Abstract. Cytokines provide important connecting links between immunity, blood clotting, and nonspecific resistance that become altered in local frostbites. The aim of study was to determine the contents of cytokines in blood of patients with local frostbites at various terms following the lesion. F...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/87 |
| _version_ | 1797198199995236352 |
|---|---|
| author | K. G. Shapovalov E. A. Tomina M. I. Mihailichenko V. A. Sizonenko Y. A. Vitkovsky |
| author_facet | K. G. Shapovalov E. A. Tomina M. I. Mihailichenko V. A. Sizonenko Y. A. Vitkovsky |
| author_sort | K. G. Shapovalov |
| collection | DOAJ |
| description | Abstract. Cytokines provide important connecting links between immunity, blood clotting, and nonspecific resistance that become altered in local frostbites. The aim of study was to determine the contents of cytokines in blood of patients with local frostbites at various terms following the lesion. Fifty patients, 17 to 50 years old, with frostbites of extremities (grade II to IV) were under observation. Arterial and venous blood, as well as venous blood from damaged and intact extremities were examined. Cytokine concentrations were determined using ELISA technique. It was shown that blood concentrations of TNFα, IL-1β, IL-4, IL-8 and IL-18 reached their maximum at early reactive period of the trauma (a 2.3- to 19-fold increase). IL-1β concentration exceeded appropriate control values during all the periods of local frostbites. IL 18 levels were increased at early reactive period of the trauma. IL-1β and IL-8 concentration at pre-reactive period proved to be higher in arterial blood of damaged extremities, than in effluent venous blood. Both during early and late reactive periods, the levels of pro-inflammatory cytokines in effluent blood from damaged extremities were 1.2- to 8-fold higher than in venous blood from intact extremities, whereas IL-4 levels were 2- to 5-fold lower. |
| first_indexed | 2024-03-08T05:52:13Z |
| format | Article |
| id | doaj.art-fda6254bc5e64c3db134df6983e2e0eb |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:56:04Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-fda6254bc5e64c3db134df6983e2e0eb2024-04-22T13:07:33ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01101899210.15789/1563-0625-2008-1-89-9285CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITESK. G. Shapovalov0E. A. Tomina1M. I. Mihailichenko2V. A. Sizonenko3Y. A. Vitkovsky4Читинская Государственная медицинская академия, г. ЧитаЧитинская Государственная медицинская академия, г. ЧитаЧитинская Государственная медицинская академия, г. ЧитаЧитинская Государственная медицинская академия, г. ЧитаЧитинская Государственная медицинская академия, г. ЧитаAbstract. Cytokines provide important connecting links between immunity, blood clotting, and nonspecific resistance that become altered in local frostbites. The aim of study was to determine the contents of cytokines in blood of patients with local frostbites at various terms following the lesion. Fifty patients, 17 to 50 years old, with frostbites of extremities (grade II to IV) were under observation. Arterial and venous blood, as well as venous blood from damaged and intact extremities were examined. Cytokine concentrations were determined using ELISA technique. It was shown that blood concentrations of TNFα, IL-1β, IL-4, IL-8 and IL-18 reached their maximum at early reactive period of the trauma (a 2.3- to 19-fold increase). IL-1β concentration exceeded appropriate control values during all the periods of local frostbites. IL 18 levels were increased at early reactive period of the trauma. IL-1β and IL-8 concentration at pre-reactive period proved to be higher in arterial blood of damaged extremities, than in effluent venous blood. Both during early and late reactive periods, the levels of pro-inflammatory cytokines in effluent blood from damaged extremities were 1.2- to 8-fold higher than in venous blood from intact extremities, whereas IL-4 levels were 2- to 5-fold lower.https://www.mimmun.ru/mimmun/article/view/87cytokinesfrostbitetnfαil-1βil-4il-8il-18 |
| spellingShingle | K. G. Shapovalov E. A. Tomina M. I. Mihailichenko V. A. Sizonenko Y. A. Vitkovsky CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES Медицинская иммунология cytokines frostbite tnfα il-1β il-4 il-8 il-18 |
| title | CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES |
| title_full | CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES |
| title_fullStr | CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES |
| title_full_unstemmed | CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES |
| title_short | CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES |
| title_sort | contents of cytokines in blood of the patients with local frostbites |
| topic | cytokines frostbite tnfα il-1β il-4 il-8 il-18 |
| url | https://www.mimmun.ru/mimmun/article/view/87 |
| work_keys_str_mv | AT kgshapovalov contentsofcytokinesinbloodofthepatientswithlocalfrostbites AT eatomina contentsofcytokinesinbloodofthepatientswithlocalfrostbites AT mimihailichenko contentsofcytokinesinbloodofthepatientswithlocalfrostbites AT vasizonenko contentsofcytokinesinbloodofthepatientswithlocalfrostbites AT yavitkovsky contentsofcytokinesinbloodofthepatientswithlocalfrostbites |