Spliceosomal Prp8 intein at the crossroads of protein and RNA splicing.
The spliceosome is a large ribonucleoprotein complex that removes introns from pre-mRNAs. At its functional core lies the essential pre-mRNA processing factor 8 (Prp8) protein. Across diverse eukaryotes, this protein cofactor of RNA catalysis harbors a self-splicing element called an intein. Inteins...
Main Authors: | Cathleen M Green, Zhong Li, Aaron D Smith, Olga Novikova, Valjean R Bacot-Davis, Fengshan Gao, Saiyang Hu, Nilesh K Banavali, Dennis J Thiele, Hongmin Li, Marlene Belfort |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-10-01
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Series: | PLoS Biology |
Online Access: | https://doi.org/10.1371/journal.pbio.3000104 |
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